Mineralocorticoid receptor

Function Mineralocorticoid receptor (MR) in epithelial cells is activated by the mineralocorticoid hormone aldosterone promoting renal sodium retention and potassium excretion. It is nuclear receptor. In non epithelial cells MR is activated by cortisol. MR is exposed to many steroids including cortisol, cortisone and progesterone, however, aldosterone and deoxycorticosterone are its physiological ligands. See also Mineralocorticoids; Steroid Hormones and their receptors and Intracellular receptors Disease MR mutations are the principal cause of renal pseudohypoaldosteronism. MR mutation S810L causes early-onset hypertension. Relevance Inhibition of cardia MR prevents doxorubicin-induced cardiotoxicity. MR is an important proadipogenic transcription factor that may mediate aldosterone and glucocorticoid effects on adipose tissue development and hence on obesity and development of metabolic syndrome. Structural highlights The MR ligand aldosterone binds in a (Alpha Helices,  Beta Strands ,  Loops , Turns). . . Water molecules are shown as red spheres.

spinqualitylabelsall models Glycosylated human mineralocorticoid receptor ligand-binding domain complex with aldosterone, glycerol and sulfate (PDB entry 2aa2) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of mineralocorticoid receptor3D Structures of mineralocorticoid receptor

Updated on 19-January-2023

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• Mineralocorticoid receptor DNA-binding site residues 593-671
  • 4tnt – hMR DBD + DNA - human
    
• Mineralocorticoid receptor DNA-binding site residues 712-984
  • 2aa2 – hMR LBD (mutant) + aldosterone
    
  • 2aa5, 2aa6 , 1ya3– hMR LBD (mutant) + progesterone
    
  • 2aa7, 2abi, 1y9r – hMR LBD (mutant) + deoxycorticosterone
    
  • 2aax – hMR LBD (mutant) + cortisone
    
  • 2ab2, 3vhu, 2oax – hMR LBD (mutant) + spironolactone
    
  • 3wff, 3wfg, 4pf3, 3vhv, 5hcv – hMR LBD (mutant) + antagonist
    
  • 6l88 – hMR LBD (mutant) + esaxerenone
    
  • 5mwy, 6gev – hMR LBD + NCOA1 peptide
    
  • 2a3i, 5mwp – hMR LBD (mutant) + NCOA1 peptide
    
  • 5l7e, 5l7g, 5l7h, 4uda, 4udb, 6gg8, 6ggg – hMR LBD + NCOA1 peptide + antagonist