Proliferating Cell Nuclear Antigen

Function Proliferating Cell Nuclear Antigen (PCNA) acts as a DNA sliding clamp by encircling the DNA and linking it to the genome. It is a processivity factor for DNA polymerase (Dpo) δ in eukaryotic cells. Relevance PCNA is useful in the diagnosis of high-grade dysplasia. Structural highlights p15 regulates DNA replication and repair by binding to PCNA. PCNA-p15 peptide complex shows the and has .

spinqualitylabelsall models Human proliferating cell nuclear antigen trimer (cyan, green, deeppink) complex with p15 peptide (yellow, magenta) (PDB entry 4d2g) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of Proliferating Cell Nuclear Antigen3D Structures of Proliferating Cell Nuclear Antigen

Updated on 14-August-2019

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• Unliganded PCNA
  • 1rwz – AfPCNA - Archaeglobus fulgidus
    
  • 3lx1 - TkPCNA1 - Thermococcus kodakarensis
    
  • 5a6d - PCNA - Thermococcus gammatolerans
    
  • 3lx2 - TkPCNA2
    
  • 3lox, 1plq, 1plr, 4yhr, 5t9d – yPCNA - yeast
    
  • 3f1x, 3gpm, 3gpn, 3f1w, 4l60, 4l6p, 6cx2, 6cx3, 6cx4, 5v7m, 5v7l, 5v7k - yPCNA (mutant)
    
  • 3l0x - yPCNA N fragment + C fragment
    
  • 3pge - yPCNA N fragment + SUMO-C fragment
    
  • 1vym, 1w60, 3vkx – hPCNA - human
    
  • 5mom, 5e0t – hPCNA (mutant)
    
  • 5e0t, 5mom - hPCNA (mutant)
    
  • 2io4 – SsPCNA B (mutant) + PCNA C - Sulfolobus solfataricus
    
  • 2hii, 2hik, 2ixi, 2ix2 - SsPCNA A + PCNA B + PCNA C
    
  • 2nti - SsPCNA A + PCNA B (mutant) + PCNA C
    
  • 2ijx - SsPCNA A
    
  • 1iz4, 1iz5, 1ge8, 5auj – PfPCNA (mutant) - Pyrococcus furiosus
    
  • 3hi8, 3ifv - PCNA - Haloferax volcanii
    
  • 3aix, 3aiz - StPCNA B + PCNA C – Sulfolobus tokodaii
    
  • 1ud9 - StPCNA
    
  • 3p91 – PCNA – Entamoeba histoytiica
    
  • 4hk1 – PCNA – Drosophila melanogaster
    
  • 4cs5 – PCNA – Litopenaeus vannamei
    
  • 5cfk, 5b7o, 5h0t, 5hac - PCNA - Leishmania donovani
    
• PCNA + Dpo
  • 2zvk – hPCNA + hDpo ε
    
  • 2zvl – hPCNA + hDpo κ
    
  • 2zvm – hPCNA + hDpo τ
    
  • 3fds – SsPCNA B + PCNA C + SsDpo IV
    
  • 3a2f - PfPCNA + Dpo
    
• PCNA complexes
  • 1vyj, 1u76, 1u7b, 6cbi, 5yd8, 5yco, 5mlw, 5mlo, 5mav, 5iy4, 4ztd, 4rjf – hPCNA + peptide
    
  • 5e0u - hPCNA (mutant) + peptide
    
  • 4d2g, 6gws – hPCNA + p15 peptide
    
  • 6e49 – hPCNA + DNA helicase peptide
    
  • 6eht – hPCNA + p15 peptide + DNA
    
  • 5e0v - hPCNA + Flap structure-specific endonuclease peptide
    
  • 4ztd - hPCNA + ubiquitin ligase peptide
    
  • 3wgw – hPCNA + inhibitor
    
  • 6gis – hPCNA + DNA
    
  • 4rjf - hPCNA + p21 peptide
    
  • 5e0u - hPCNA (mutant) + p21
    
  • 1axc - hPCNA + P21/WAF1 C-terminat
    
  • 1ul1 - hPCNA + Flap exonuclease-1
    
  • 5e0v - hPCNA (mutant) + Flap endonoclease 1
    
  • 3p87 - hPCNA + RNase H2 subunit B (mutant)
    
  • 3tbl - hPCNA + ubiquitin
    
  • 5iy4 - hPCNA + DVC1 PIP box
    
  • 5mlo, 5mlw - hPCNA + ZRANB3 peptide
    
  • 5mav - hPCNA + PARG peptidee
    
  • 6gis - hPCNA + DNA
    
  • 3p83 - AfPCNA + RNase H2
    
  • 1rxm – AfPCNA + Flap exonuclease-1 peptide
    
  • 1rxz - AfPCNA + Flap structure-specific endonuclease
    
  • 3l0w, 3l10 - yPCNA + monoubiquinated PCNA
    
  • 1sxj – yPCNA + replication factor C
    
  • 2od8 - yPCNA + DNA ligase fragment
    
  • 3k4x - yPCNA + DNA
    
  • 3v60, 3v61 – yPCNA (mutant) + ubiquitin-like protein SMT3
    
  • 3v62 – yPCNA (mutant) + ubiquitin-like protein SMT3 + ATP-dependent DNA helicase SRS2
    
  • 5zut – yPCNA + peptide
    
  • 5jne - yPCNA (mutant) + SMT3 + E2
    
  • 2izo - SsPCNA B + PCNA C + Flap structure-specific endonuclease
    
  • 1isq - PfPCNA (mutant) + replication factor C large subunit
    
  • 2zvw, 2zvv - PCNA + cyclin-dependent kinase inhibitor 1 - Arabidopsis thaliana
    
  • 5da7 - TkPCNA + protein inhibitor