Adhesin

Function Adhesins (Adh) are surface components of bacteria which facillitate adhesion to surfaces or other cells. Adh are specific surface recognition protein and are regarded as virulence factors. FimH is the E. coli adhesin which is part of the type 1 pili of the bacteria. The pili is composed of subunits FimF, FimG and FimD. For trimeric autotransporter adhesin see EibD. Disease Bacterial pathogens use adhesins as a major factor in adhesion-based virulence. Adhesins serve as vaccine targets since they are essential to infection. Structural highlights (PDB ID 4f8p) . Water molecules are shown as red spheres. .

spinqualitylabelsall models Adhesin PsaA complex with tert-butyl formate and galactose (stick model) (PDB ID 4f8p) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of adhesin3D Structures of adhesin

Updated on 20-December-2018

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• Fimbrial adhesin
  • 4k0o, 2bs8, 2bsc, 2bsb, 5nwp – EcF17b-G lectin domain – Escherichia coli
    
  • 1o9z, 1o9w, 1o9v – EcF17a-G lectin domain
    
  • 5vq5 – EcF17 lectin domain (mutant)
    
  • 1oio – EcF17c lectin domain
    
  • 4b4p, 4bwo – EcF18 lectin domain
    
  • 4auu, 1uwf, 1tr7, 5fwr – EcAdh FimH lectin domain
    
  • 5mca, 5fx3 – EcAdh FimH lectin domain (mutant)
    
  • 5afo – EcAdh LF82
    
  • 6aow – EcAdh FMLH lectin domain
    
  • 3zk7 – SpPsaA - Streptococcus pneumoniae
    
  • 3zk8, 3zk9, 3zka – SpPsaA (mutant)
    
  • 3u4k – Adh lectin domain – Klebsiella pneumoniae
    
• Fimbrial adhesion complexes
  • 4b4q, 4b4r – EcF18 lectin domain + hexasaccharide
    
  • 4w6w, 4w6x, 4w6y – EcF18 lectin domain + nanobody
    
  • 4j3o – EcAdh FimH + FimG + FimC + FimF + FimD
    
  • 3rfz, 1ze3 – EcAdh FimH + FimC + FimD
    
  • 1qun, 1klf, 1kiu – EcAdh FimH + FimC
    
  • 4xo9 – EcAdh FimH + DSG residues 24-37
    
  • 4xod, 4xoa – EcAdh FimH + FimG residues 24-37
    
  • 4xob – EcAdh FimH + FimF residues 24-37 + mannoside derivative
    
  • 5jr4, 5jqi – EcAdh FimH (mutant) + FimG N-terminal
    
  • 6as8, 6arm, 6aoy – EcAdh FMLD lectin domain + galactoside derivative
    
  • 6aox – EcAdh FMLD lectin domain + TF antigen
    
  • 6aro – EcAdh FMLH lectin domain + quinoline derivative
    
  • 5muc, 5l4y, 5l4x, 5l4w, 5l4v, 5l4u, 5l4t, 5jcq, 5jcr, 5f2f, 5f3f, 5abz, 4xo8, 4x5p, 4x5q, 4x5r, 4lov, 4css, 4cst, 4att, 4auj, 4auy, 4av0, 4av4, 4av5, 4avh, 4avi, 4avj, 4avk, 3zl1, 3zl2, 2vco – EcAdh FimH lectin domain + mannoside derivative
    
  • 5cgb – EcAdh FimH lectin domain + galactitol
    
  • 5ab1, 4x50 – EcAdh FimH + mannoside derivative
    
  • 5aap, 5aal, 5mts – EcAdh FimH lectin domain + anti-adhesive
    
  • 3f6j, 3f64, 1zpl, 1zk5 – EcF17a-G lectin domain + GlcNAc derivative
    
  • 1psz – SpPsaA + Zn – Streptococcus pneumonia
    
  • 3ztt – SpPsaA + Mn
    
  • 4utp, 4uto – SpPsaA + Cd
    
  • 2bs7 – EcF17b-G lectin domain + chitobiose
    
  • 3ffo – EcF17b-G lectin domain + GlcNac-Man
    
  • 4b4q, 4b4r – EcFedF lectin domain + hexasaccharide
    
  • 4w6w, 4w6x, 4w6y – EcFedF lectin domain + nanobody
    
  • 4f8l – YpPsaA + galactose + inhibitor – Yersinia pestis
    
  • 4f8n – YpPsaA + galactose + phosphate choline
    
  • 4f8o – YpPsaA + lactose + inhibitor
    
  • 4f8p – YpPsaA + galactose
    
• Epitheial adhesin
  • 4d3w, 4asl, 4af9 – CgAdh epithelial 1 A domain – Candida glabrata
    
  • 4afc, 4afb, 4afa – CgAdh epithelial 1 A domain (mutant)
    
  • 4cp2, 4cp1, 4cp0 – CgAdh epithelial 9 A domain
    
  • 4coz, 4coy, 4cow, 4cov, 4cou – CgAdh epithelial 6 A domain
    
• Collagen adhesin (CAdh)
  • 1amx – SaCAdh CBD – Staphylococcus aureus
    
  • 1d2o – SaCAdh B1 repeat unit
    
  • 1d2p – SaCAdh B1-B2 repeat units
    
  • 2f68 – SaCAdh extracellular domain
    
  • 2f6a – SaCAdh extracellular domain + collagen
    
  • 2okm, 2z1p – CAdh CBD – Enterococcus faecalis
    
  • 1p9h – YeYadA CBD – Yersinia enterocolitica
    
  • 3h7x – YeYadA stalk domain
    
  • 3h7z – YeYadA stalk domain (mutant)
    
  • 3lt6, 3lt7 – YeYadA coiled coil
    
  • 2lme – YeYadA coiled coil - NMR
    
• Serine-rich adhesin for platelets (SRAP)
  • 4m00 – SaSRAP LBD
    
  • 4m01 – SaSRAP LBD N-terminal
    
  • 4m02 – SaSRAP LBD middle region
    
  • 4m03 – SaSRAP LBD C-terminal
    
• Adhesin
  • 2odl, 2gr8, 2gr7 – HiAdh secretion domain – Haemophilus influenzae
    
  • 3emf – HiAdh residues 51-166
    
  • 3emi – HiAdh residues 307-422 (mutant)
    
  • 1s7m – HiAdh residues 548-706
    
  • 3emo – HiAdh residues 937-1098
    
  • 4zh7, 4zh0 – Adh BABA – Helicobacter pylori
    
  • 4usx – Adh trimeric autotransporter – Burkholderia pseudomallei
    
  • 3wqa, 3wpr, 3wpp, 3wpo, 3wpa – AcAdh trimeric autotransporter C-terminal – Acinetobacter
    
  • 3wp8 – AcAdh trimeric autotransporter C-terminal (mutant)
    
  • 4err – Adh autotransporter effector domain – Vibrio vulnificus
    
  • 2wps, 2wpr, 2wpq – Adh trimeric autotransporter residues 483-523 – Salmonella enterica
    
  • 4tsh – Adh surface protein – Streptococcus mutans
    
  • 4mee – EcAdh diffuse adherence C-terminal
    
  • 5lvy – EcAdh lectin domain
    
  • 3etw – FnAdh A – Fusobacterium nucleatum
    
  • 3etz, 3ety, 3etx, 2gl2 – FnAdh A (mutant)
    
  • 3d9x – Adh A – Bartonella henselae
    
  • 2lwb – Adh WI-1 – Ajellomyces dermatitidis
    
  • 5my7 – Adh – Neisseria meningitidis