Fatty acid-binding protein

Fatty acid-binding protein (FABP) are carrier proteins for fatty acids and other lipophilic substances. They facilitate the transfer of fatty acids between extra- and intracellular membranes. FABS coordinate lipid trafficking and signaling in cells. Various FABS differ in their tissue expression. IFABP is intestinal; HFABP is heart-type; BFABP is brain-type; LFABP is liver-type; AFABP is adipocyte; LMDABP is from flight muscle; TFABP is from testis. Relevance Some FABSs are linked to metabolic and inflammatory pathways. Structural insights The (Hydrophobic, Polar).

spinqualitylabelsall models Human brain-type fatty acid-binding protein complex with oleate (PDB code 1fe3) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of fatty acid-binding protein3D structures of fatty acid-binding protein

Updated on 22-December-2016

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• Intestinal fatty acid-binding protein
  • 1ael, 1a57, 1sa8 - rIFABP – rat – NMR
    
  • 1t8v - rIFABP (mutant) – NMR
    
  • 1ifb, 1ifc - rIFABP
    
  • 1dc9 - rIFABP (mutant)
    
  • 1kzw, 3ifb - hIFABP – human – NMR
    
  • 1kzx - hIFABP (mutant) – NMR
    
• Intestinal fatty acid-binding protein binary complex
  • 3akm, 2mo5 - hIFABP + fatty acid analog
    
  • 2mji - hIFABP + ketorolac - NMR
    
  • 3akn, 1icm, 1icn, 2ifb - rIFABP + fatty acid analog
    
  • 1ure - rIFABP + palmitate – NMR
    
• Epidermal fatty acid-binding protein
  • 1b56, 1jjj, 4lkp - hEFABP
    
  • 4azr, 4lkt - hEFABP + fatty acid
    
  • 4azn, 4azo - mEFABP
    
  • 4azp, 4azq - mEFABP + fatty acid
    
  • 4azm - hEFABP + inhibitor
    
• Heart-type fatty acid-binding protein
  • 1g5w - hHFABP – NMR
    
  • 3rsw, 5ce4 – hHFABP
    
  • 3wbg – hHFABP + sulfonate derivative
    
  • 5hz9 – hHFABP + inhibitor
    
  • 3wvm, 4tjz, 4tkb, 4tkh, 4tkj, 4wbk, 3wxq - hHFABP + fatty acid
    
  • 1bwy – HFABP – bovine
    
  • 5d8j – HFABP + Fab – mouse
    
• Brain-type fatty acid-binding protein
  • 1fdq, 1jjx - hBFABP
    
  • 1fe3 - hBFABP + oleate
    
• Liver-type fatty acid-binding protein
  • 1p6p - LFABP – toad
    
  • 1tvq, 1mvg - cLFABP – chicken
    
  • 1zry - cLFABP - NMR
    
  • 2f73, 3stn, 3b2h, 3b2i, 3b2j, 3b2k, 3b2l, 3vg2, 3vg3, 3vg4, 3vg5, 3vg6, 3vg7 - hLFABP
    
  • 2py1, 2l67, 2l68 - hLFABP – NMR
    
  • 2ju3, 2ju7 - rLFABP – NMR
    
  • 2ft9 – AmLFABP - Ambystoma mexicanum
• Liver-type fatty acid-binding protein binary complex
  • 3stk, 3stm - hLFABP + palmitate
    
  • 2lkk - hLFABP + oleate – NMR
    
  • 2ju8 - rLFABP + oleate – NMR
    
  • 1lfo - rLFABP + oleate
    
  • 1tw4, 2jn3, 2lfo - cLFABP + cholate
    
  • 2jn3 - cLFABP + chenodeoxycholate
    
  • 2k62 - cLFABP + bile acid-based Gd chelate
    
  • 2ftb - AmLFABP + oleate
    
  • 2qo4 – zLFABP + cholate – zebrafish
    
  • 2qo5, 2qo6 – zLFABP (mutant) + cholate
    
• Adipocyte fatty acid-binding protein
  • 1tou, 2hnx, 3q6l, 3rzy - hAFABP
    
  • 1lib, 1alb – mAFABP
    
  • 1g7n, 1ab0, 1acd - mAFABP (mutant)
    
  • 1tow - hAFABP + carbazole butanoic acid
    
  • 2nnq, 3fr2, 3fr4, 3fr5, 5hz6, 5hz8, 5d45, 5d47, 5d48, 5d4a, 5edb, 5edc, 4nns, 4nnt - hAFABP + inhibitor
    
  • 3p6c - hAFABP + citrate
    
  • 3p6d, 3p6e - hAFABP + propionate derivative
    
  • 3p6f - hAFABP + phenyl-butyrate
    
  • 3p6g, 3p6h - hAFABP + ibuprofen
    
  • 2qm9 - mAFABP + troglitazone
    
  • 2q9s, 1lid, 1lie, 1lif, 1adl - mAFABP + fatty acid
    
  • 1g74 - mAFABP (mutant) + fatty acid
    
  • 3hk1, 3js1, 3jsq - mAFABP + inhibitor
    
  • 1lic, 2ans – mAFABP + sulfonic acid derivative
    
  • 1a18 - mAFABP + phenanthroline
    
  • 1a2d - mAFABP + pyridoxamine
    
  • 5c0n - mAFABP + Fab
    
• Flight muscle fatty acid-binding protein
  • 2flj, 1ftp - LMFABP – locust
• Muscle fatty acid-binding protein
  • 2hmb – hMFABP
    
  • 1hmr, 1hms, 1hmt – hMFABP + fatty acid
    
• Testis fatty acid-binding protein
  • 4a60 - hTFABP
• Ileal bile acid-binding protein
  • 3elx – zIBABP
    
  • 3elz, 3em0 – zIBABP + cholate
    
• Other fatty acid-binding protein
  • 2poa - SmFABP (mutant) - Schistosoma mansoni – NMR
    
  • 1mdc – FABP – tobacco hornworm
    
  • 4jgx - FABP – Yarrowia lipolytica
    
  • 1vyf, 1vyg – SmFABP + fatty acid
    
  • 3w9k – FABP + fatty acid – Sulfolobus tokodaii
    
  • 2n93 – FABP – Luciola cerata - NMR
    
  • 5bvq – PpFABP – Pygoscelis papua
    
  • 5bvs, 5bvt – PpFABP + fatty acid