Fatty acid-binding protein

Fatty acid-binding protein (FABP) are carrier proteins for fatty acids and other lipophilic substances. They facilitate the transfer of fatty acids between extra- and intracellular membranes. FABS coordinate lipid trafficking and signaling in cells^[1]. Various FABS differ in their tissue expression.

IFABP is intestinal;
HFABP is heart-type;
BFABP is brain-type;
LFABP is liver-type;
AFABP is adipocyte;
LMDABP is from flight muscle;
TFABP is from testis.

Relevance

Some FABSs are linked to metabolic and inflammatory pathways.

Structural insights

The (Hydrophobic, Polar)^[2].

3D structures of fatty acid-binding protein

Fatty acid-binding protein 3D structures

Human brain-type fatty acid-binding protein complex with oleate (PDB code 1fe3)

Drag the structure with the mouse to rotate

ReferencesReferences

↑ Chmurzynska A. The multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphism. J Appl Genet. 2006;47(1):39-48. PMID:16424607 doi:http://dx.doi.org/10.1007/BF03194597
↑ Balendiran GK, Schnutgen F, Scapin G, Borchers T, Xhong N, Lim K, Godbout R, Spener F, Sacchettini JC. Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein. J Biol Chem. 2000 Sep 1;275(35):27045-54. PMID:10854433 doi:10.1074/jbc.M003001200

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Michal Harel, Alexander Berchansky

[1] Chmurzynska A. The multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphism. J Appl Genet. 2006;47(1):39-48. PMID:16424607 doi:http://dx.doi.org/10.1007/BF03194597

[2] Balendiran GK, Schnutgen F, Scapin G, Borchers T, Xhong N, Lim K, Godbout R, Spener F, Sacchettini JC. Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein. J Biol Chem. 2000 Sep 1;275(35):27045-54. PMID:10854433 doi:10.1074/jbc.M003001200

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