Alpha-glucosidase

Function Alpha glucosidase (AGS) or maltase beaks down the 1,4-α bonds in starch or disaccharides to produce glucose. Maltase breaks down maltose. Isomaltase breaks the 1,6 bond. See also Kennedy research. Disease AGS deficiency is the cause of Pompe Disease. AGS inhibitors are used as anti-diabetic drugs and can potentially prevent the fusion of HIV and hepatitis B virus to cells. Structural highlights (PDB code 3a4a).

spinqualitylabelsall models Structure of yeast isomaltase complex with α-D-glucose and Ca+2 ion (green) (PDB code 3a4a). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of α-glucosidase3D structures of α-glucosidase

Updated on 02-November-2016

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• Alpha glucosidase
  • 2g3m – SsAGS – Sulfolobus solfataricus
    
  • 2ze0 – AGS – Geobacillus
    
  • 3w38 – bAGS - beet
    
  • 2d73, 2jka, 3wfa, 5djw, 5f7c, 3wfa – BtAGS – Bacterioides thetaiotaomicron
    
  • 5f0e – mAGS - mouse
    
  • 5aed, 5aee, 5aeg – AGS - Esherichia coli
    
  • 3wy1 – HaAGS - Halomonas
    
  • 4xpo – PsAGS - Pedobacter saltans
    
  • 4xpr – PsAGS (mutant)
    
• Maltase complex
  • 1vjt – TmAGS + NAD – Thermotoga maritima
    
  • 1obb – TmAGS + NAD + maltose
    
  • 2g3n – SsAGS + octylglucoside
    
• Isomaltase
  • 3a47, 3aj7 – yAGS – yeast
    
  • 3a4a, 3axh – yAGS + glucose
    
  • 3axi – yAGS (mutant) + glucose
    
  • 3n04 – RoAGS – Ruminococcus obeum
    
  • 3nsx, 3nuk – RoAGS (mutant)
    
  • 3pha, 3poc – RoAGS (mutant) + acarbose
    
  • 3mkk – RoAGS + isomaltose
    
• Alpha-glucosidase complex
  • 2jke – BtAGS + deoxynojirimycin
    
  • 2jkp – BtAGS + castasnospermine
    
  • 2zq0 – BtAGS + acarbose
    
  • 5h9o – mAGS + glucose
    
  • 5hjo – mAGS + substrate analog
    
  • 5h9r – mAGS + intermediate
    
  • 5ied, 5iee, 5ief, 5ieg – mAGS + iminosugar antiviral
    
  • 3wy2 – HaAGS + glucose
    
  • 3wy3 – HaAGS (mutant) + glucose
    
  • 3wy4 – HaAGS (mutant) + maltose
    
  • 4xpp – PsAGS + galactose
    
  • 4xpq – PsAGS + fucose
    
  • 4xps – PsAGS (mutant) + galactpiranoside
    
  • 3wel, 3wem, 3wen, 3weo, 3w37 – bAGS + substrate