Proteasome

Proteasome (PRTS) are large protein complexes which degrade unneeded proteins into small polypeptides. The 26S PRTS is composed of a central 20S core particle which contains 4 stacked rings each with several members and two 19S caps. The core particle two outer rings contain 7 α subunits which form the PRTS gate. The two inner rings contain 6 β subunits with protease activity. The 19S cap is composed of a base with 10 proteins six of which are ATPases and a lid which contains 9 proteins which bind polyubiquitin.
For more details see 3unb.

3D Structures of Proteasome3D Structures of Proteasome

Updated on 13-July-2016

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• Proteasome 20S particle
  • 3mfe, 3mi0, 2fhg – Mt20S core – Mycobacterium tuberculosis
    
  • 3gpt, 3gpw, 1g0u – y20S core - yeast
    
  • 1ryp, 3wxr, 4qux, 4quy, 4qv0, 4qv1, 4qv3, 4qv4, 4qv5, 4qv6, 4qv7, 4qv8, 4qv9 - y20S core (mutant)
    
  • 4r3o – h20S – human
    
  • 3mka, 3hfa – Mt20S core (mutant)
    
  • 3c91, 3c92, 1pma, 3j9i – Ta20S core - Themoplasma acidophilum
    
  • 3h4p – 20S core – Methanocaldococcus janaschii
    
  • 2h6j, 1q5r – Re20S core (mutant) – Rhodococcus erythropolis
    
  • 1q5q - Re20S core
    
  • 1j2q – Af20S core - Archaeoglobus fulgidus
    
  • 1iru – 20S core - bovine
    
  • 3une – m20S core – mouse
    
  • 3unh – m20S core (immuno)
• Proteasome 20S+activator protein
  • 1vsy, 3l5q – y20S core+ Blm10
    
  • 1z7q, 1fnt – y20S core+PA26
    
  • 3ipm, 3jrm, 3jse, 3jtl, 1ya7, 1yar, 1yau - Taa-PRTS chains A-G+ Tab-PRTS chains H-N+PA26 chains O-U
    
• Proteasome 20S+inhibitor
  • 3hye, 3gpj, 3dy3, 3dy4, 3e47, 3d29, 3bdm, 2zcy, 2gpl, 2fak, 2f16, 1jd2, 1g65, 3mg0, 3mg4, 3mg6, 3mg7, 3mg8, 3oeu, 3oev, 3okj, 3shj, 3un4, 3un8, 3sdi, 3sdk, 4fzc, 4fzg, 4gk7, 4eu2, 4inr, 4int, 4inu, 4jsq, 4jsu, 4jt0, 4qwx, 4qzz, 4r17, 4r18, 4rur, 5ahj – y20S core+inhibitor
    
  • 4qxj, 4qz0, 4qz1, 4qz2, 4qz3, 4qz4, 4qz5, 4qz6, 4qz7, 4qzw, 4qzx, 4r00, 4r02 – y20S (mutant) + inhibitor
    
  • 3tdd, 4j70 - y20S core + belactosin
    
  • 4hnp, 4hrc, 4hrd, 4lqi, 4ltc, 4q1s - y20S core + antibiotics
    
  • 4nnn, 4nnw, 4no1, 4no6, 4no8, 4no9, 4qby, 4qlq, 4qls, 4qlt, 4qlu, 4qlv - y20S core+ peptide inhibitor
    
  • 3h6f, 3h6i, 3hf9, 2fhh, 3krd – Mt20S core+inhibitor
    
  • 3nzj, 3nzw, 3nzx - y20S + TMC-95A mimic ligand
    
  • 2zcy – y20S+syringolin
    
  • 4qvl, 4qw4 – y20S + lymphoma drug
    
  • 4qvm, 4qvn, 4qvp, 4qvq, 4qvv, 4qvw, 4qvy, 4qw0, 4qw1, 4qw3, 4qw5, 4qw6, 4qw7, 4qwf, 4qwg, 4qwi, 4qwj, 4qwk, 4qwl, 4qwr, 4qws, 4qwu – y20S (mutant) + lymphoma drug
    
  • 4r67 – h20S + cancer drug
    
  • 3unb, 3unf – m20S + inhibitor
• Proteasome partial 20S particle
  • 2ku1, 2ku2 – Taa-PRTS chains A-G
    
  • 3fp9 – MtATPase chains A-L
    
  • 1j2p – Af α subunit
    
  • 2jay – Mt β subunit
    
  • 2kqz, 2kr0 – hPRTS ubiquitin receptor domain
• Proteasome partial 26S particle
  • 1p9c – hPRTS subunit 4 C-terminal
    
  • 1p9d - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain
    
  • 1uel - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain - NMR
    
  • 1yx4 - hPRTS subunit 4 – NMR
    
  • 1yx5, 1yx6, 2kde, 2kdf - hPRTS subunit 4+ubiquitin – NMR
    
  • 2o95, 2o96 - hPRTS subunit 7
    
  • 3kw6 - hPRTS subunit 8
    
  • 2krk - hPRTS subunit 8 – NMR
    
  • 1qym, 1uoh - hPRTS subunit 10
    
  • 1tr4 - hPRTS subunit 10 – NMR
    
  • 4nik - hPRTS subunit 10 + single-chain Fv
    
  • 3t5x - hPRTS subunit Dss1 + PCI domain-containing protein 2
    
  • 2dvw, 2dwz - mPRTS subunit 10 + hPRTS subunit 6B – mouse
    
  • 3aji - mPRTS subunit 10 + subunit 4
    
  • 2x5n - PRTS subunit RPN10 VWA domain – fission yeast
    
  • 4ady - yPRTS subunit RPN2
    
  • 3vlf - yPRTS subunit 7 + DNA mismatch repair protein
    
  • 2mr3 - yPRTS subunit RPN9 – NMR
    
  • 2mqw - yPRTS subunit RPN9 N terminal – NMR
    
  • 2mri - yPRTS subunit RPN9 C terminal – NMR
    
  • 4b0z - yPRTS subunit RPN12
    
  • 2z4d - yPRTS subunit RPN13
    
  • 3vl1 - yPRTS subunit RPN14 (mutant)
    
  • 4o8x, 4o8y - yPRTS subunit RPN8 + RPN11
    
  • 4ocl, 4ocm, 4ocn - yPRTS subunit RPN8 + RPN11 + nanobody
    
  • 3t5v - yPRTS subunit SEM1 + nuclear mRNA export proteins SAC3 and THP1
    
  • 2z59 - mPRTS subunit RPN13+ubiquitin
    
  • 3txm, 3txn – PRTS subunit P42B – Drosophila melanogaster
• Proteasome 26S particle
  • 4b4t, 3j47, 4cr2, 4cr3, 4cr4 – yPRTS – Cryo EM
    
  • 4g4s – yPRTS + proteasome assembly chaperon 1 & 2