Cell death protein

Cell death proteins or Programmed cell death protein or CD279 (CED) are involved in the process of cellular apoptosis. CED-1 is a T cell regulator. CED-1 is expressed on the surface of T cells, B cells and macrophages. It is a membrane protein and acts in suppressing the immune system during pregnancy, tissue allografts, autoimmune diseases and hepatitis. CED-1 has 2 ligands: CED-L1 and CED-L2. Formation of CED-1/CED-L1 complex reduces T cell proliferation at the lymph nodes. For details on CED-4 see CED-4 Apoptosome.

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3D structures of cell death protein3D structures of cell death protein

Updated on 29-November-2015

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• CED-1
  • 1npu – mCED-1 extracellular domain (mutant) - mouse
    
  • 3rrq - hCED-1 extracellular domain (mutant) - human
    
  • 4zqk - hCED-1 extracellular domain (mutant) + hCED-1 ligand
    
  • 2m2d - hCED-1 extracellular domain - NMR
    
  • 3bik - mCED-1 extracellular domain (mutant) + hCED-L1 extracellular domain
    
  • 3sbw - mCED-1 extracellular domain + hCED-L1 extracellular domain
    
  • 3rnq - mCED-1 extracellular domain + mCED-L2 extracellular domain
    
  • 3bp5, 3bp6 - mCED-1 extracellular domain (mutant) + mCED-L2 extracellular domain
    
  • 3rnk - mCED-1 extracellular domain (mutant) + mCED-L2 IgV domain
    
• CED-2
  • 3qwx, 3qwy - CeCED-2 – Caenorhabditis elegans
• CED-3
  • 4m9r - nCED-3 - nematode
    
• CED-4
  • 2a5y - CeCED-4 + CeCED-9
    
  • 3lqq, 3lqr - CeCED-4
    
  • 2ggf – hCED-4 MA3 domain – NMR
    
  • 2rg8, 2kzt - hCED-4 MA3 domain
    
  • 2iol, 2ion, 2ios, 2nsz - mCED-4 MA3 domain
    
  • 2hm8 - mCED-4 MA3 domain – NMR
    
  • 3eij - hCED-4 residues 157-469
    
  • 2zu6, 3eiq - hCED-4 residues 163-469 + eukaryotic initiation factor 4A-I
    
  • 4m9s, 4m9x, 4m9y, 4m9z - nCED-4 + nCED-3 fragment
    
• CED-5
  • 1yyb - hCED-5 N terminal – NMR
    
  • 2cru, 2k6b - hCED-5 – NMR
    
• CED-6
  • 1y1x - CED-6 – Leishmania major
    
  • 1hqv - mCED-6
    
  • 2zn8, 2zn9, 2znd, 2zrs, 2zrt - hCED-6
    
  • 3aaj, 3aak - hCED-6 (mutant)
    
  • 2zne - hCED-6 + CED-6-interacting protein
    
  • 3wxa - hCED-6 + SEC31A peptide
    
• CED-8
  • 1gv4 - mCED-8
    
  • 1m6i - hCED-8
    
• CED-9
  • 1ohu – CeCED-9
    
  • 1ty4 - CeCED-9 + programmed CED activator
• CED-10
  • 3ajm - hCED-10 + inositol tetrakisphosphate
    
  • 3l8i, 3l8j - hCED-10
    
  • 3rqe, 3rqf, 3rqg - hCED-10 + paxillidin peptide
    
  • 3w8h, 3w8i, 4geh - hCED-10 + serine/threonine kinase regulatory domain
    
• CED-HAC-1
  • 1vt4, 3iz8 – CED-HAC-1 – Drosophila melanogaster