Proteopedia

Cell death protein


Cell death proteins or Programmed cell death protein or CD279 (CED) are involved in the process of cellular apoptosis.

  • CED-1 is a T cell regulator. CED-1 is expressed on the surface of T cells, B cells and macrophages. It is a membrane protein and acts in suppressing the immune system during pregnancy, tissue allografts, autoimmune diseases and hepatitis. CED-1 has 2 ligands: CED-L1 and CED-L2. Formation of CED-1/CED-L1 complex reduces T cell proliferation at the lymph nodes. [1] CED-1 and CED-L1 complex with glycerol</scene> (3bik).
  • CED-3 is a cysteine protease involved in apoptosis[2].
  • CED-4 attenuates tumorigenesis by translational contro[3]. lFor details on CED-4 see CED-4 Apoptosome[4].
  • CED-5 can accelerate apoptosis in different kinds of cells in response to different stimuli[5].
  • CED-6 has a role in modulating cellular angiogenesis[6].
  • For details on CED-8 see Apoptosis-inducing factor.
  • CED-9 prevents cells from undergoing programmed cell death, It is similar to Bcl2[7].
  • CED-10 regulates apoptosis in malignant T cells[8].

Cell death protein 3D structures

Human CED-1 extracellular domain. Programmed cell death protein 1 (green and magenta) and programmed cell death 1 ligand 1 (cyan) complex with glycerol (PDB code 3bik)

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Zak KM, Kitel R, Przetocka S, Golik P, Guzik K, Musielak B, Domling A, Dubin G, Holak TA. Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1. Structure. 2015 Oct 22. pii: S0969-2126(15)00402-5. doi:, 10.1016/j.str.2015.09.010. PMID:26602187 doi:http://dx.doi.org/10.1016/j.str.2015.09.010
  2. ↑ Xue D, Shaham S, Horvitz HR. The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease. Genes Dev. 1996 May 1;10(9):1073-83. PMID:8654923 doi:10.1101/gad.10.9.1073
  3. ↑ Wang Q, Yang HS. The role of Pdcd4 in tumour suppression and protein translation. Biol Cell. 2018 May 28:10.1111/boc.201800014. PMID:29806708 doi:10.1111/boc.201800014
  4. ↑ Lin DY, Tanaka Y, Iwasaki M, Gittis AG, Su HP, Mikami B, Okazaki T, Honjo T, Minato N, Garboczi DN. The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3011-6. Epub 2008 Feb 14. PMID:18287011
  5. ↑ Malottki K, Popat S, Deeks JJ, Riley RD, Nicholson AG, Billingham L. Problems of variable biomarker evaluation in stratified medicine research--A case study of ERCC1 in non-small-cell lung cancer. Lung Cancer. 2016 Feb;92:1-7. PMID:26775588 doi:10.1016/j.lungcan.2015.11.017
  6. ↑ Rho SB, Song YJ, Lim MC, Lee SH, Kim BR, Park SY. Programmed cell death 6 (PDCD6) inhibits angiogenesis through PI3K/mTOR/p70S6K pathway by interacting of VEGFR-2. Cell Signal. 2012 Jan;24(1):131-9. PMID:21893193 doi:10.1016/j.cellsig.2011.08.013
  7. ↑ Xue D, Horvitz HR. Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor. Nature. 1997 Nov 20;390(6657):305-8. PMID:9384385 doi:10.1038/36889
  8. ↑ Lauenborg B, Kopp K, Krejsgaard T, Eriksen KW, Geisler C, Dabelsteen S, Gniadecki R, Zhang Q, Wasik MA, Woetmann A, Odum N. Programmed cell death-10 enhances proliferation and protects malignant T cells from apoptosis. APMIS. 2010 Oct;118(10):719-28. PMID:20854465 doi:10.1111/j.1600-0463.2010.02669.x

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