Cell death protein

spinqualitylabelsall models PDB ID 3bik Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Cell death proteins or Programmed cell death protein or CD279 (CED) are involved in the process of cellular apoptosis. CED-1 is a T cell regulator. CED-1 is expressed on the surface of T cells, B cells and macrophages. It is a membrane protein and acts in suppressing the immune system during pregnancy, tissue allografts, autoimmune diseases and hepatitis. CED-1 has 2 ligands: CED-L1 and CED-L2. Formation of CED-1/CED-L1 complex reduces T cell proliferation at the lymph nodes. For details on CED-4 see CED-4 Apoptosome.

3D structures of cell death protein3D structures of cell death protein

Updated on 29-November-2015

{"openlevels":0}

• CED-1
  • 1npu – mCED-1 extracellular domain (mutant) - mouse
    
  • 3rrq - hCED-1 extracellular domain (mutant) - human
    
  • 4zqk - hCED-1 extracellular domain (mutant) + hCED-1 ligand
    
  • 2m2d - hCED-1 extracellular domain - NMR
    
  • 3bik - mCED-1 extracellular domain (mutant) + hCED-L1 extracellular domain
    
  • 3sbw - mCED-1 extracellular domain + hCED-L1 extracellular domain
    
  • 3rnq - mCED-1 extracellular domain + mCED-L2 extracellular domain
    
  • 3bp5, 3bp6 - mCED-1 extracellular domain (mutant) + mCED-L2 extracellular domain
    
  • 3rnk - mCED-1 extracellular domain (mutant) + mCED-L2 IgV domain
    
• CED-2
  • 3qwx, 3qwy - CeCED-2 – Caenorhabditis elegans
• CED-3
  • 4m9r - nCED-3 - nematode
    
• CED-4
  • 2a5y - CeCED-4 + CeCED-9
    
  • 3lqq, 3lqr - CeCED-4
    
  • 2ggf – hCED-4 MA3 domain – NMR
    
  • 2rg8, 2kzt - hCED-4 MA3 domain
    
  • 2iol, 2ion, 2ios, 2nsz - mCED-4 MA3 domain
    
  • 2hm8 - mCED-4 MA3 domain – NMR
    
  • 3eij - hCED-4 residues 157-469
    
  • 2zu6, 3eiq - hCED-4 residues 163-469 + eukaryotic initiation factor 4A-I
    
  • 4m9s, 4m9x, 4m9y, 4m9z - nCED-4 + nCED-3 fragment
    
• CED-5
  • 1yyb - hCED-5 N terminal – NMR
    
  • 2cru, 2k6b - hCED-5 – NMR
    
• CED-6
  • 1y1x - CED-6 – Leishmania major
    
  • 1hqv - mCED-6
    
  • 2zn8, 2zn9, 2znd, 2zrs, 2zrt - hCED-6
    
  • 3aaj, 3aak - hCED-6 (mutant)
    
  • 2zne - hCED-6 + CED-6-interacting protein
    
  • 3wxa - hCED-6 + SEC31A peptide
    
• CED-8
  • 1gv4 - mCED-8
    
  • 1m6i - hCED-8
    
• CED-9
  • 1ohu – CeCED-9
    
  • 1ty4 - CeCED-9 + programmed CED activator
• CED-10
  • 3ajm - hCED-10 + inositol tetrakisphosphate
    
  • 3l8i, 3l8j - hCED-10
    
  • 3rqe, 3rqf, 3rqg - hCED-10 + paxillidin peptide
    
  • 3w8h, 3w8i, 4geh - hCED-10 + serine/threonine kinase regulatory domain
    
• CED-HAC-1
  • 1vt4, 3iz8 – CED-HAC-1 – Drosophila melanogaster