Proteasome

Proteasome (PRTS) are large protein complexes which degrade unneeded proteins into small polypeptides. The 26S PRTS is composed of a central 20S core particle which contains 4 stacked rings each with several members and two 19S caps. The core particle two outer rings contain 7 α subunits which form the PRTS gate. The two inner rings contain 6 β subunits with protease activity. The 19S cap is composed of a base with 10 proteins six of which are ATPases and a lid which contains 9 proteins which bind polyubiquitin. The images at the left and at the right correspond to one representative Proteasome, i.e. the crystal structure of yeast Proteasome (3gpt).

3D Structures of Proteasome3D Structures of Proteasome

Updated on 21-May-2015

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• Proteasome 20S particle
  • 3mfe, 3mi0, 2fhg – Mt20S core – Mycobacterium tuberculosis
    
  • 3gpt, 3gpw, 1g0u – y20S core - yeast
    
  • 1ryp, 3wxr, 4qux, 4quy, 4qv0, 4qv1, 4qv3, 4qv4, 4qv5, 4qv6, 4qv7, 4qv8, 4qv9 - y20S core (mutant)
    
  • 4r3o – h20S – human
    
  • 3mka, 3hfa – Mt20S core (mutant)
    
  • 3c91, 3c92, 1pma, 3j9i – Ta20S core - Themoplasma acidophilum
    
  • 3h4p – 20S core – Methanocaldococcus janaschii
    
  • 2h6j, 1q5r – Re20S core (mutant) – Rhodococcus erythropolis
    
  • 1q5q - Re20S core
    
  • 1j2q – Af20S core - Archaeoglobus fulgidus
    
  • 1iru – 20S core - bovine
    
  • 3une – m20S core – mouse
    
  • 3unh – m20S core (immuno)
• Proteasome 20S+activator protein
  • 1vsy, 3l5q – y20S core+ Blm10
    
  • 1z7q, 1fnt – y20S core+PA26
    
  • 3ipm, 3jrm, 3jse, 3jtl, 1ya7, 1yar, 1yau - Taa-PRTS chains A-G+ Tab-PRTS chains H-N+PA26 chains O-U
    
• Proteasome 20S+inhibitor
  • 3hye, 3gpj, 3dy3, 3dy4, 3e47, 3d29, 3bdm, 2zcy, 2gpl, 2fak, 2f16, 1jd2, 1g65, 3mg0, 3mg4, 3mg6, 3mg7, 3mg8, 3oeu, 3oev, 3okj, 3shj, 3un4, 3un8, 3sdi, 3sdk, 4fzc, 4fzg, 4gk7, 4eu2, 4inr, 4int, 4inu, 4jsq, 4jsu, 4jt0, 4qwx, 4qzz, 4r17, 4r18, 4rur, 5ahj – y20S core+inhibitor
    
  • 4qxj, 4qz0, 4qz1, 4qz2, 4qz3, 4qz4, 4qz5, 4qz6, 4qz7, 4qzw, 4qzx, 4r00, 4r02 – y20S (mutant) + inhibitor
    
  • 3tdd, 4j70 - y20S core + belactosin
    
  • 4hnp, 4hrc, 4hrd, 4lqi, 4ltc, 4q1s - y20S core + antibiotics
    
  • 4nnn, 4nnw, 4no1, 4no6, 4no8, 4no9, 4qby, 4qlq, 4qls, 4qlt, 4qlu, 4qlv - y20S core+ peptide inhibitor
    
  • 3h6f, 3h6i, 3hf9, 2fhh, 3krd – Mt20S core+inhibitor
    
  • 3nzj, 3nzw, 3nzx - y20S + TMC-95A mimic ligand
    
  • 2zcy – y20S+syringolin
    
  • 4qvl, 4qw4 – y20S + lymphoma drug
    
  • 4qvm, 4qvn, 4qvp, 4qvq, 4qvv, 4qvw, 4qvy, 4qw0, 4qw1, 4qw3, 4qw5, 4qw6, 4qw7, 4qwf, 4qwg, 4qwi, 4qwj, 4qwk, 4qwl, 4qwr, 4qws, 4qwu – y20S (mutant) + lymphoma drug
    
  • 4r67 – h20S + cancer drug
    
  • 3unb, 3unf – m20S + inhibitor
• Proteasome partial 20S particle
  • 2ku1, 2ku2 – Taa-PRTS chains A-G
    
  • 3fp9 – MtATPase chains A-L
    
  • 1j2p – Af α subunit
    
  • 2jay – Mt β subunit
    
  • 2kqz, 2kr0 – hPRTS ubiquitin receptor domain
• Proteasome partial 26S particle
  • 1p9c – hPRTS subunit 4 C-terminal
    
  • 1p9d - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain
    
  • 1uel - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain - NMR
    
  • 1yx4 - hPRTS subunit 4 – NMR
    
  • 1yx5, 1yx6, 2kde, 2kdf - hPRTS subunit 4+ubiquitin – NMR
    
  • 2o95, 2o96 - hPRTS subunit 7
    
  • 3kw6 - hPRTS subunit 8
    
  • 2krk - hPRTS subunit 8 – NMR
    
  • 1qym, 1uoh - hPRTS subunit 10
    
  • 1tr4 - hPRTS subunit 10 – NMR
    
  • 4nik - hPRTS subunit 10 + single-chain Fv
    
  • 3t5x - hPRTS subunit Dss1 + PCI domain-containing protein 2
    
  • 2dvw, 2dwz - mPRTS subunit 10 + hPRTS subunit 6B – mouse
    
  • 3aji - mPRTS subunit 10 + subunit 4
    
  • 2x5n - PRTS subunit RPN10 VWA domain – fission yeast
    
  • 4ady - yPRTS subunit RPN2
    
  • 3vlf - yPRTS subunit 7 + DNA mismatch repair protein
    
  • 2mr3 - yPRTS subunit RPN9 – NMR
    
  • 2mqw - yPRTS subunit RPN9 N terminal – NMR
    
  • 2mri - yPRTS subunit RPN9 C terminal – NMR
    
  • 4b0z - yPRTS subunit RPN12
    
  • 2z4d - yPRTS subunit RPN13
    
  • 3vl1 - yPRTS subunit RPN14 (mutant)
    
  • 4o8x, 4o8y - yPRTS subunit RPN8 + RPN11
    
  • 4ocl, 4ocm, 4ocn - yPRTS subunit RPN8 + RPN11 + nanobody
    
  • 3t5v - yPRTS subunit SEM1 + nuclear mRNA export proteins SAC3 and THP1
    
  • 2z59 - mPRTS subunit RPN13+ubiquitin
    
  • 3txm, 3txn – PRTS subunit P42B – Drosophila melanogaster
• Proteasome 26S particle
  • 4b4t, 3j47, 4cr2, 4cr3, 4cr4 – yPRTS – Cryo EM
    
  • 4g4s – yPRTS + proteasome assembly chaperon 1 & 2