Prostaglandin F synthase

Prostaglandin F synthase (AKR1C3) catalyzes the conversion of aldehydes and ketones to alcohol using NADH or NADP as cofactor. I catalyzes the isomerization of prostaglandin H2 (PGH2) to prostaglandin F2α (PGF2α) and the formation of 11β-PGF2α from prostaglandin D2 (PGD2). PGH2 is a potent vasoconstrictor; PGF2α is used to treat impotence and abortion. PGD2 is critical in the development of allergic diseases like asthma. Inhibitors of AKR1C3 – mainly non-steroidal anti-inflammatory compounds (NSAID) like flufenamic acid, mefenamic acid, indomethacin, naproxen, ibuprofen are used as drugs. AKR1C3 also catalyzes the NADPH reduction of progesterone, estrone and androstene-dione.

spinqualitylabelsall models Structure of human prostaglandin F synthase complex with cofactor NADP and NSAID drug (PDB entry 1s2c) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of prostaglandin F synthase3D structures of prostaglandin F synthase

Updated on 20-May-2015

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• Prostaglandin F synthase
  • 4f40 – LmAKR1C3 – Leishmania major
    
  • 4fzi – TcAKR1C3 – Trypanosoma cruzi
    
• Prostaglandin F synthase binary complex with NADP
  • 1s1p, 1s1r, 2fgb – hAKR1C3 + NADP - human
    
  • 4dz5 – hAKR1C3 (mutant) + NADP
    
  • 1vbj – AKR1C3 + NADP – Trypanosoma brucei
    
  • 4g5d – LmAKR1C3 + NADP
    
  • 4gie – TcAKR1C3 + NADP
    
• Prostaglandin F synthase ternary complex with NADP
  • 1s2a, 1s2c, 3r43, 3r58, 3r6i, 3r7m, 3r8g, 3r8h, 3r94, 3ufy, 3ug8, 3ugr, 4dbw, 4xve, 4xvd, 4wrh, 4wdx, 4wdw, 4wdt, 4wdu, 4hmn, 4h7c – hAKR1C3 + NADP + NSAID drug
    
  • 1xf0 – hAKR1C3 + NADP + androstene-dione
    
  • 1ry0 – hAKR1C3 + NADP + PGD2
    
  • 1ry8, 1zq5, 4dbs, 4dbu, 4fa3, 4fal, 4fam, 4h7c – hAKR1C3 + NADP + inhibitor
    
  • 2f38 – hAKR1C3 + NADP + glaucoma drug
    
  • 3uwe – hAKR1C3 + NADP + phenoxybenzoic acid