1vbj

The crystal structure of prostaglandin F synthase from Trypanosoma bruceiThe crystal structure of prostaglandin F synthase from Trypanosoma brucei

Structural highlights

1vbj is a 2 chain structure with sequence from Trypanosoma brucei. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.1Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PGFS_TRYBB Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity towards the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Kubata BK, Duszenko M, Kabututu Z, Rawer M, Szallies A, Fujimori K, Inui T, Nozaki T, Yamashita K, Horii T, Urade Y, Hayaishi O. Identification of a novel prostaglandin f(2alpha) synthase in Trypanosoma brucei. J Exp Med. 2000 Nov 6;192(9):1327-38. PMID:11067881

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OCA

[1] Kubata BK, Duszenko M, Kabututu Z, Rawer M, Szallies A, Fujimori K, Inui T, Nozaki T, Yamashita K, Horii T, Urade Y, Hayaishi O. Identification of a novel prostaglandin f(2alpha) synthase in Trypanosoma brucei. J Exp Med. 2000 Nov 6;192(9):1327-38. PMID:11067881

[1]

1vbj

The crystal structure of prostaglandin F synthase from Trypanosoma bruceiThe crystal structure of prostaglandin F synthase from Trypanosoma brucei

Structural highlights

Function

Evolutionary Conservation

See Also

References

Contents

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1vbj

The crystal structure of prostaglandin F synthase from Trypanosoma bruceiThe crystal structure of prostaglandin F synthase from Trypanosoma brucei

Structural highlights

Function

Evolutionary Conservation

See Also

References

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