Azurin

<StructureSection load='5azu' size='340' side='right' caption='Structure of azurin containing Cu+2 ion complex with nitrate (PDB code 5azu).' scene=>

FunctionFunction

Azurin (AZ) is a blue copper protein. AZ mediates electron transfer and contains type I copper center.

RelevanceRelevance

AZ was found to be a novel anticancer agent. Following the entry of the P. aeruginosa bacteria into human melanoma and breast cancer cells, the AZ complexes with the tumor suppressor p53. The complex stabilizes p53 and activates the apoptosis of the cancer cells.

3D structures of cAMP-dependent protein kinase3D structures of cAMP-dependent protein kinase

Updated on 18-November-2014

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• Azurin
  • 1e65 – PaAZ – Pseudomonas aeruginosa
    
• Cu+2 containing azurin
  • 1azu, 1azr, 4azu, 5azu, 1azn, 1cc3, 1e5y, 1e5z, 1jze, 2ft6, 2ft7, 2ft8, 2fta, 3fs9, 3fsa, 3fsv, 3fsw, 3fsz, 3ft0 – PaAZ
    
  • 1joi – PfAZ – Pseudomonas fluorrescens
    
  • 1nwo – PpAZ – Pseudomonas putida
    
  • 1nwp – PpAZ + Zn+2
    
  • 2aza, 1azb, 1azc – AxAZ – Achromobacter xylosoxidans
    
  • 2azu, 3azu, 1ils, 1ilu, 2tsa, 2tsb, 1etj, 1ag0, 1ezl, 1jvo, 1gr7, 1xb3, 1xb6, 1xb8, 2ghz, 2hx7, 2oj1, 3in0, 3fpy, 3fq1, [3fq2]], 3fqy, 3in2, 3jt2, 3jtb, 3np3, 3np4, 3oqr, 3n2j, 3u25, 4hhw, 4mfh, 4ko5, 4ko6, 4ko7, 4ko9, 4kob, 4koc, 4bww – PaAZ (mutant)
    
  • 1jvl, 2idf – PaAZ (mutant) + Ni+2
    
  • 1uri, 1a4a, 1a4b, 1a4c – AdAZ (mutant)
    
  • 2h3x, 2h47, 2iaa – AZ + aromatic amine dehydrogenase – Alcaligenes faecalis
    
• Cu+2 containing lanthanide-modified azurin
  • 1bex, 1jzi, 1jze, 1jzf, 1jzj, 1jsh – PaAZ
    
  • 2i7s, 2fnw, 2i7o, 3ibo, 4hhg, 4k9j – PaAZ (mutant)
    
• Cu+1 containing azurin
  • 1jzg – PaAZ
    
  • 1r1c, 2gi0, 1i53, 2hx8, 2hx9, 2hxa, 2xv0, 2xv2, 2xv3 – PaAZ (mutant)
    
• Other metals-containing azurin
  • 1aiz – AdAZ + Cd+2 – Achromobacter denitrificans
    
  • 1nzr – PaAZ (mutant) + Ni+2
    
  • 1vlx – PaAZ + Co+2
    
  • 1e67 – PaAZ + Zn+2
    
  • 2iwe – PaAZ (mutant) + Zn+2
    
  • 3uge – PaAZ + Ag+1
    
  • 4hz1 – PaAZ + Fe+2
    
  • 4jkn – PaAZ + Hg+2