Azurin

Function

Azurin (AZ) is a blue copper protein. AZ mediates electron transfer and contains type I copper center.

For details see Intramolecular Electron Transfer in Azurin.

Relevance

AZ was found to be a novel anticancer agent. Following the entry of the P. aeruginosa bacteria into human melanoma and breast cancer cells, the AZ complexes with the tumor suppressor p53. The complex stabilizes p53 and activates the apoptosis of the cancer cells.

Structural highlights

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3D structures of azurin

Azurin 3D structures

ReferencesReferences

↑ Zhu DW, Dahms T, Willis K, Szabo AG, Lee X. Crystallization and preliminary crystallographic studies of the crystals of the azurin Pseudomonas fluorescens. Arch Biochem Biophys. 1994 Feb 1;308(2):469-70. PMID:8109977 doi:http://dx.doi.org/10.1006/abbi.1994.1066

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Michal Harel, Alexander Berchansky

[1] Zhu DW, Dahms T, Willis K, Szabo AG, Lee X. Crystallization and preliminary crystallographic studies of the crystals of the azurin Pseudomonas fluorescens. Arch Biochem Biophys. 1994 Feb 1;308(2):469-70. PMID:8109977 doi:http://dx.doi.org/10.1006/abbi.1994.1066

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