Fatty acid-binding protein

Fatty acid-binding protein (FABP) are carrier proteins for fatty acids and other lipophilic substances. They facilitate the transfer of fatty acids between extra- and intracellular membranes. FABS coordinate lipid trafficking and signaling in cells. Some FABSs are linked to metabolic and inflammatory pathways. Various FABS differ in their tissue expression. IFABP is intestinal; HFABP is heart-type; BFABP is brain-type; LFABP is liver-type; AFABP is adipocyte; LMDABP is from flight muscle; TFABP is from testis; EXFABP is extracellular.

3D structures of fatty acid-binding protein3D structures of fatty acid-binding protein

Updated on 05-March-2014

Intestinal fatty acid-binding protein

1ael, 1a57, 1sa8 - rIFABP – rat – NMR
1t8v - rIFABP (mutant) – NMR
1ifb, 1ifc - rIFABP
1dc9 - rIFABP (mutant)
1kzw, 3ifb - hIFABP – human – NMR
1kzx - hIFABP (mutant) – NMR

Intestinal fatty acid-binding protein binary complex

3akm - hIFABP + fatty acid analog
3akn, 1icm, 1icn, 2ifb - rIFABP + fatty acid analog
1ure - rIFABP + palmitate – NMR

Epidermal fatty acid-binding protein

1b56, 1jjj - hEFABP
4azr - hEFABP + fatty acid
4azn, 4azo - mEFABP
4azp, 4azq - mEFABP + fatty acid
4azm - hEFABP + inhibitor

Heart-type fatty acid-binding protein

1g5w - hHFABP – NMR
3rsw – hHFABP
3wbg – hHFABP + sulfonate derivative
1bwy – HFABP – bovine

Brain-type fatty acid-binding protein

1fdq, 1jjx - hBFABP
1fe3 - hBFABP + oleate

Liver-type fatty acid-binding protein

1p6p - LFABP – toad
1tvq, 1mvg - cLFABP – chicken
1zry - cLFABP - NMR
2f73, 3stn, 3b2h, 3b2i, 3b2j, 3b2k, 3b2l, 3vg2, 3vg3, 3vg4, 3vg5, 3vg6, 3vg7 - hLFABP
2py1, 2l67, 2l68 - hLFABP – NMR
2ju3, 2ju7 - rLFABP – NMR
2ft9 – AmLFABP - Ambystoma mexicanum

Liver-type fatty acid-binding protein binary complex

3stk, 3stm - hLFABP + palmitate
2lkk - hLFABP + oleate – NMR
2ju8 - rLFABP + oleate – NMR
1lfo - rLFABP + oleate
1tw4, 2jn3, 2lfo - cLFABP + cholate
2jn3 - cLFABP + chenodeoxycholate
2k62 - cLFABP + bile acid-based Gd chelate
2ftb - AmLFABP + oleate
2qo4 – zLFABP + cholate – zebrafish
2qo5, 2qo6 – zLFABP (mutant) + cholate

Adipocyte fatty acid-binding protein

1tou, 2hnx, 3q6l, 3rzy - hAFABP
1lib, 1alb – mAFABP
1g7n, 1ab0, 1acd - mAFABP (mutant)
1tow - hAFABP + carbazole butanoic acid
2nnq, 3fr2, 3fr4, 3fr5 - hAFABP + inhibitor
3p6c - hAFABP + citrate
3p6d, 3p6e - hAFABP + propionate derivative
3p6f - hAFABP + phenyl-butyrate
3p6g, 3p6h - hAFABP + ibuprofen
2qm9 - mAFABP + troglitazone
2q9s, 1lid, 1lie, 1lif, 1adl - mAFABP + fatty acid
1g74 - mAFABP (mutant) + fatty acid
3hk1, 3js1, 3jsq - mAFABP + inhibitor
1lic, 2ans – mAFABP + sulfonic acid derivative
1a18 - mAFABP + phenanthroline
1a2d - mAFABP + pyridoxamine

Flight muscle fatty acid-binding protein

2flj, 1ftp - LMFABP – locust

Muscle fatty acid-binding protein

2hmb – hMFABP
1hmr, 1hms, 1hmt – hMFABP + fatty acid

Testis fatty acid-binding protein

4a60 - hTFABP

Extracellular fatty acid-binding protein

2kt4 - qEXFABP – quail
2lbv - qEXFABS + enterobactin
3sao - cEXFABP + myristoyl lysophosphatidic acid

2poa - SmFABP (mutant) - Schistosoma mansoni – NMR
1mdc – FABP – tobacco hornworm
4jgx - FABP – Yarrowia lipolytica
1vyf, 1vyg – SmFABP + fatty acid
3w9k – FABP + fatty acid – Sulfolobus tokodaii