Nucleoporin

Template:STRUCTURE 1xip Nucleoporins (NUP) are constituents of the nuclear pore complex which regulates the flow of macromolecules across the nuclear envelope. They are named according to their molecular weights. They contain a domain which binds the protein RAN (RANBD), N-terminal domain (NTD) and C-terminal domain (CTD). The images at the left and at the right correspond to one representative Nucleoporin structure, i.e. crystal structure of yeast Nucleoporin NUP159 from Saccharomyces cerevisiae (1xip),

File:1xip.png

Crystal structure of the N-terminal domain of yeast Nucleoporin NUP159, 1xip

3D Structures of Nucleoporin3D Structures of Nucleoporin

Updated February 2013

NUP2NUP2

3n7c – NUP2 RANBD – Ashbya gossypii
2c1t – yNUP2 NTD +importrin alpha subunit - yeast

NUP35NUP35

1wwh – mNUP35 MPPN domain - mouse

NUP37NUP37

4fhl – fyNUP37 – fission yeast
4fhm, 4fhn, 4gq2 - fyNUP37 + NUP120

NUP50NUP50

2ec1 – hNUP50 RANBD - human
2c1m – mNUP50 NTD +importin

NUP53NUP53

3p3d - NUP53 RRM domain - Pischia guillermondii

NUP54NUP54

3t97 – rNUP54 + NUP62 - rat

NUP58NUP58

2osz – rNUP58/45

NUP82NUP82

3pbp – yNUP82 NTD + NUP116 CTD + NUP159 tail
3tkn - yNUP82 NTD + NUP98 + NUP159 tail

NUP84NUP84

3jro, 3iko – yNUP84+NUP145+protein Sec13

NUP85NUP85

3f3f, 3f3g, 3f3p, 3ewe – yNUP85+Seh1

NUP98NUP98

3mmy – hNUP98 fragment+mRNA export factor
2q5x, 2q5y – hNUP98 CTD
1ko6 – hNUP98 CTD

NUP100NUP100

3nf5 – NUP100 CTD – Candida glabrata

NUP107NUP107

3i4r, 3cqc, 3cqg – hNUP107+NUP133

NUP116NUP116

2aiv – yNUP116 CTD - NMR

NUP120NUP120

3f7f, 3h7n, 3hxr – yNUP120

NUP133NUP133

1xks – hNUP133 NTD
3kfo – yNUP133 CTD

NUP145NUP145

3bg0, 3bg1 – hNUP145+Sec13-related protein
3kep, 3kes – yNUP145 autoproteolytic domain
3jrp - yNUP145+protein Sec13

NUP153NUP153

3gj3, 3gj4, 3gj5, 3gj6, 3gj7, 3gj8, 3ch5 – hNUP153+RAN
2ebq, 2ebr, 2ebv, 2gqe - hNUP153 RANBD – NMR
2k0c – rNUP153 RANBD – NMR

NUP159NUP159

1xip – yNUP159 NTD
3rrm – yNUP159 residues 2-387 + NUP Gle1 + IP6 + ADP

NUP170NUP170

3i5p, 3i5q – yNUP170

NUP214NUP214

3fmo, 3fmp, 3fhc – hNUP214+dead-box helicase
2oit – hNUP214 NTD

NUP358NUP358

1z5s – hNUP358 IR1 domain+ubiquitin-conjugating enzyme+SMT3C+RAN CTD
1xke - hNUP358 RANBD - NMR

NUP1PNUP1P

2bpt – yNUP1P+importin β subunit

NUP2PNUP2P

1un0 – yNUP2P NTD+importrin α subunit

NUP-NSP1NUP-NSP1

1o6o – yNUP-NSP1 residues 497-608+importrin β subunit

NUP-CDC31NUP-CDC31

2doq, 2gv5 – yNUP-CDC31+SFI1P
3fwb, 3fwc - yNUP-CDC31+SAC3

NUP Gle1NUP Gle1

3peu, 3pev, 3rrn– yNUP-Gle1 + ATP-dependent RNA helicase Dbp5 (mutant) +IP6

2rfo, 2qx5 – yNic96
1gyb – NUP+yNTF2