Epidermal growth factor

Template:STRUCTURE 2kv4

Epidermal growth factor (EGF) plays a role in cell growth. It binds to its receptor (EGFR). EGF is regulated by iodine. EGF is part of a family of proteins with similar structure and activity. All EGF family proteins contain a conserved amino acid sequence which includes 3 disulfide bonds.

3D structures of epidermal growth factor3D structures of epidermal growth factor

1egf, 1epg, 1eph, 1epi, 1epj, 3egf – mEGF – mouse – NMR
1a3p – mEGF (mutant) – NMR
1jl9, 2kv4 – hEGF
1gk5, 1p9j – hEGF/transforming growth factor alpha - NMR

Heparin-binding EGF-like growth factorHeparin-binding EGF-like growth factor

1xdt –h HB-EGF extracellular domain + diphtheria toxin

EGF-like Cripto proteinEGF-like Cripto protein

2j5h – mCR-EGF residues 96-134 - NMR

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky