Nucleoporin

Template:STRUCTURE 1xip Nucleoporins (NUP) are constituents of the nuclear pore complex which regulates the flow of macromolecules across the nuclear envelope. They are named according to their molecular weights. They contain a domain which binds the protein RAN (RANBD). The images at the left and at the right correspond to one representative Nucleoporin structure, i.e. crystal structure of yeast Nucleoporin NUP159 from Saccharomyces cerevisiae (1xip),

File:1xip.png

Crystal structure of the N-terminal domain of yeast Nucleoporin NUP159, 1xip

3D Structures of Nucleoporin3D Structures of Nucleoporin

NUP2NUP2

3n7c – NUP2 RANBD – Ashbya gossypii
2c1t – yNUP2 N-terminal+importrin alpha subunit - yeast

NUP35NUP35

1wwh – mNUP35 MPPN domain - mouse

NUP50NUP50

2ec1 – hNUP50 RANBD - human
2c1m – mNUP50 N-terminal+importin

NUP53NUP53

3p3d - NUP53 RRM domain - Pischia guillermondii

NUP58NUP58

2osz – rNUP58/45 - rat

NUP84NUP84

3jro, 3iko – yNUP84+NUP145+protein Sec13

NUP85NUP85

3f3f, 3f3g, 3f3p, 3ewe – yNUP85+Seh1

NUP98NUP98

3mmy – hNUP98 fragment+mRNA export factor
2q5x, 2q5y – hNUP98 C-terminal
1ko6 – hNUP98 C-terminal

NUP100NUP100

3nf5 – NUP100 C-terminal – Candida glabrata

NUP107NUP107

3i4r, 3cqc, 3cqg – hNUP107+NUP133

NUP116NUP116

2aiv – yNUP116 C-terminal - NMR

NUP120NUP120

3f7f, 3h7n, 3hxr – yNUP120

NUP133NUP133

1xks – hNUP133 N-terminal
3kfo – yNUP133 C-terminal

NUP145NUP145

3bg0, 3bg1 – hNUP145+Sec13-related protein
3kep, 3kes – yNUP145 autoproteolytic domain
3jrp - yNUP145+protein Sec13

NUP153NUP153

3gj3, 3gj4, 3gj5, 3gj6, 3gj7, 3gj8, 3ch5 – hNUP153+RAN
2ebq, 2ebr, 2ebv, 2gqe - hNUP153 RANBD – NMR
2k0c – rNUP153 RANBD – NMR

NUP159NUP159

1xip – yNUP159 N-terminal

NUP170NUP170

3i5p, 3i5q – yNUP170

NUP214NUP214

3fmo, 3fmp, 3fhc – hNUP214+dead-box helicase
2oit – hNUP214 N-terminal

NUP358NUP358

1z5s – hNUP358 IR1 domain+ubiquitin-conjugating enzyme+SMT3C+RAN C-terminal
1xke - hNUP358 RANBD - NMR

NUP1PNUP1P

2bpt – yNUP1P+importin β subunit

NUP2PNUP2P

1un0 – yNUP2P N-terminal+importrin α subunit

NUP-NSP1NUP-NSP1

1o6o – yNUP-NSP1 residues 497-608+importrin β subunit

NUP-CDC31NUP-CDC31

2doq, 2gv5 – yNUP-CDC31+SFI1P
3fwb, 3fwc - yNUP-CDC31+SAC3
2rfo, 2qx5 – yNic96
1gyb – NUP+yNTF2

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel, Jaime Prilusky, Joel L. Sussman