Nucleoporin
Template:STRUCTURE 1xip Nucleoporins (NUP) are constituents of the nuclear pore complex which regulates the flow of macromolecules across the nuclear envelope. They are named according to their molecular weights. They contain a domain which binds the protein RAN (RANBD). The images at the left and at the right correspond to one representative Nucleoporin structure, i.e. crystal structure of yeast Nucleoporin NUP159 from Saccharomyces cerevisiae (1xip),
3D Structures of Nucleoporin3D Structures of Nucleoporin
3n7c – NUP2 RANBD – Ashbya gossypii
2c1t – yNUP2 N-terminal+importrin alpha subunit - yeast
1wwh – mNUP35 MPPN domain - mouse
2ec1 – hNUP50 RANBD - human
2c1m – mNUP50 N-terminal+importin
2osz – rNUP58/45 - rat
3jro, 3iko – yNUP84+NUP145+protein Sec13
3f3f, 3f3g, 3f3p, 3ewe – yNUP85+Seh1
3mmy – hNUP98 fragment+mRNA export factor
2q5x, 2q5y – hNUP98 C-terminal
1ko6 – hNUP98 C-terminal
3nf5 – NUP100 C-terminal – Candida glabrata
3i4r, 3cqc, 3cqg – hNUP107+NUP133
2aiv – yNUP116 C-terminal - NMR
3f7f, 3h7n, 3hxr – yNUP120
1xks – hNUP133 N-terminal
3kfo – yNUP133 C-terminal
3bg0, 3bg1 – hNUP145+Sec13-related protein
3kep, 3kes – yNUP145 autoproteolytic domain
3jrp - yNUP145+protein Sec13
3gj3, 3gj4, 3gj5, 3gj6, 3gj7, 3gj8, 3ch5 – hNUP153+RAN
2ebq, 2ebr, 2ebv, 2gqe - hNUP153 RANBD – NMR
2k0c – rNUP153 RANBD – NMR
1xip – yNUP159 N-terminal
3i5p, 3i5q – yNUP170
3fmo, 3fmp, 3fhc – hNUP214+dead-box helicase
2oit – hNUP214 N-terminal
1z5s – hNUP358 IR1 domain+ubiquitin-conjugating enzyme+SMT3C+RAN C-terminal
1xke - hNUP358 RANBD - NMR
2bpt – yNUP1P+importin β subunit
1un0 – yNUP2P N-terminal+importrin α subunit
1o6o – yNUP-NSP1 residues 497-608+importrin β subunit
2doq, 2gv5 – yNUP-CDC31+SFI1P
3fwb, 3fwc - yNUP-CDC31+SAC3
2rfo, 2qx5 – yNic96
1gyb – NUP+yNTF2