Monooxygenase 3D structures

3D structures of monooxygenase3D structures of monooxygenase

Updated on 09-September-2020

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• Toluene 4-monooxygenase (TMO)
  • 3dhg, 3i5j, 2inc – PmTMO α+β+γ subunits + Fe – Pseudomonas mendocina
    
  • 2ind – PmTMO α+β+γ subunits + Mn
    
  • 3rng, 3rnf, 3rne, 3rnc, 3rnb, 3rna, 3rn9, 3n20, 3n1z, 3n1y, 3n1x, 2rdb – PmTMO α+β+γ subunits (mutant) + Fe
    
  • 1sjg – PmTMO protein C + Fe
    
  • 1vm9 – PmTMO protein C (mutant) + Fe
    
  • 2bf5, 2bf3, 2bf2 – PmTMO protein D
    
  • 4wqm – PmTMO (mutant) + Ni
    
  • 4p1c, 4p1b – PmTMO protein A+B+E+ferredoxin (mutant) + Fe
    
  • 2q3w – PmTMO ferredoxin subunit (mutant) + Fe
    
• TMO complexes
  • 3dhh, 3q3n, 3q3o – PmTMO α+β+γ subunits + Fe + phenol derivative + TMO system effector protein
    
  • 3rmk, 1t0s, 1t0q – PmTMO α+β+γ subunits + Fe + phenol derivative
    
  • 3q14 – PmTMO α+β+γ subunits + Fe + p-cresol + TMO system effector protein
    
  • 3q2a, 3q3m – PmTMO α+β+γ subunits + Fe + benzoate inhibitor + TMO system effector protein
    
  • 3dhi – PmTMO α+β+γ subunits + Fe + TMO system effector protein
    
  • 3ge3, 3ge8, 3ri7 – PmTMO α (mutant)+β+γ subunits + Fe + TMO system effector protein
    
  • 3i63 – PmTMO α+β+γ subunits + Fe + TMO system effector protein + H2O2
    
  • 5tdv – PmTMO protein A+B+D+E + Fe + peroxide
    
  • 5tdu – PmTMO protein A+B+D+E + Fe + cresol
    
  • 5tdt – PmTMO protein A+B+D+E + Fe + peroxide + toluene
    
  • 5tds – PmTMO protein A+B+D+E + Fe + toluene
    
  • 1t0r – PsTMO + Fe + OH – Pseudomonas stutzeri
    
• Heme-degrading monooxygenase (IsdI)
  • 2zdp – SaIsdI + heme-Co – Staphylococcus aureus
    
  • 3lgm, 2zdo – SaIsdI + heme-Fe
    
  • 4fnh – SaIsdI (mutant) + heme-Fe
    
  • 3lgn – SaIsdI + heme-Fe + O2
    
  • 3qgp – SaIsdI + heme-Fe + CN
    
  • 4fni – SaIsdI (mutant) + heme-Fe + CN
    
  • 4nl5 – MtMO + heme + CN – Mycobacterium tuberculosis
    
  • 4oz5 – MO + heme – Bacillus subtilis
    
• Kynurenine 3-monooxygenase (KMO)
  • 5x68 – hKMO + FAD - human
    
  • 4j2w, 4j31, 4j33, 4j34 – yKMO + FAD – yeast
    
  • 4j36, 5x6r – yKMO + FAD + inhibitor
    
  • 5x6q – yKMO (mutant) + FAD + inhibitor
    
  • 5na5, 5x6p – PfKMO (mutant) + FAD – Pseudomonas fluorescens
    
  • 5y7a, 5y77, 6fox – PfKMO + FAD + kynurenine
    
  • 5nak – PfKMO (mutant) + FAD + kynurenine
    
  • 5y66 – PfKMO + FAD + kynurenine + inhibitor
    
  • 6fph, 6fp1, 6fp0, 6foz, 6foy – PfKMO + FAD + inhibitor
    
  • 5nah, 5nag, 5nae, 5nab, 5n7t, 5mzk, 5mzi, 5mzc, 5fn0 – PfKMO (mutant) + FAD + inhibitor
    
• Phenol 2-monooxygenase (PMO)
  • 1foh – TcPMO + FAD – Trichosporon cutaneum
    
  • 1pn0 – TcPMO + FAD + phenol
    
• Phenylalanine 2-monooxygenase
  • 5pah, 6pah – hFMO catalytic domain + inhibitor
    
• ActVA-Orf6 monooxygenase (AOMO)
  • 1lq9 – ScAOMO – Streptomyces coelicolor
    
  • 1n5q – ScAOMO + sancycline
    
  • 1n5s, 1n5t – ScAOMO + acetyl dithranol
    
  • 1n5v – ScAOMO + nanaomycine
    
• Baeyer-Villiger monooxygenase (BVMO)
  • 6jdk – BVMO + FAD – Parvibaculum lavamentivorans
    
  • 6y48 – BVMO + FAD + NADP – Aspergillus flavus
    
• Flavin-containing monooxygenase
  • 6wpu – MO + FAD – garlic
    
  • 2gv8 – fyMO + FAD + NADP – fission yeast
    
  • 2gvc – fyMO + FAD + NADP + methimazole
    
  • 4a9w – SmMO + FAD – Stenotrophomonas maltophilia
    
  • 4c5o – SmMO (mutant) + FAD
    
  • 5wan – EcMO + FMN + uracil – Escherichia coli
    
  • 5iq4, 5iq1, 5ipy – RnMO (mutant) + FAD + NAP – Roseovarius nubinhibens
    
  • 5gsn – RnMO (mutant) + FAD + NAP + methimazole
    
  • 4usr – PsMO + FAD
    
  • 3rp6 – KpMO + FAD – Klebsiella pneumoniae
    
  • 3rp8 – KpMO (mutant) + FAD
    
  • 3rp7 – KpMO + FAD + uric acid
    
  • 3c96, 2rgj – PaMO + FAD – Pseudomonas aeruginosa
    
  • 2xvf, 2xve – MaMO + FAD – Methylophaga aminisulfidivorans
    
  • 2xvj – MaMO (mutant) + FAD + indole
    
  • 2xvi – MaMO (mutant) + FAD + O2
    
  • 2vqb – MaMO (mutant) + FAD + NADP + O2
    
  • 2xvh, 2xlu, 2xlt – MaMO + FAD + NADP derivative
    
  • 2xls, 2xlr, 2xlp, 2vq7 – MaMO (mutant) + FAD + NADP
    
  • 5nmw – ZvMO + FAD – Zonocerus variegatus
    
  • 5nmx – ZvMO + FAD + NADP
    
  • 6kbw – MO + FAD + NADP – Myroides profundi
    
  • 6se3, 6sek, 6sem, 6sf0 – MO + FAD + NADP + O2 – synthetic
    
  • 6u0p – StMO + FAD – Streptomyces
    
  • 6u0s – StMO + FAD + pyridine derivative
    

*2,4,6-trichlorophenol 4-monooxygenase

• • 4g5e – MO – Cupriavidus necator
    

*Chlorophenol 4-monooxygenase

• • 4oo2 – MO – Streptomyces globisporus
    
  • 3k86, 3hwc – BcMO – Burkholderia cepacia
    
  • 3k87 – BcMO + FAD
    
  • 3k88 – BcMO + FAD + NAD
    
  • 6jhm – MO – Ralstonia pickettii
    

*Phenylacetone monooxygenase

• • 4ovi, 4c74 – TfMO + FAD + APADP – Thermobifida fusca
    
  • 1w4x – TfMO + FAD
    
  • 2ylt, 2yls, 2ylr – TfMO + FAD + NADP
    
  • 2ylz – TfMO (mutant) + FAD
    
  • 4c77 – TfMO (mutant) + FAD + APADP
    
  • 4d04 – TfMO (mutant) + FAD + NAP
    
  • 4d03, 2ym2, 2ylx, 2ylw – TfMO (mutant) + FAD + NADP
    
  • 2ym1 – TfMO (mutant) + FAD + NADP + O2
    

*6-hydroxynicotinate 3-monooxygenase

• • 5eow – PpMO + FAD – Pseudomonas putida
    

*Styrene monooxygenase

• • 3ihm – PpMO
    
  • 4f07 – PpMO (mutant) + FAD
    

*Tryptophan 2-monooxygenase

• • 4iv9 – MO + FAD – Pseudomonas savastanoi
    

*Tryptophan 5-monooxygenase

• • 1mlw – hMO + Fe + dihydrobiopterin
    

*Tyrosine 3-monooxygenase

• • 2xsn – hMO + Zn
    
  • 2toh – rMO + Fe + dihydrobiopterin + tyrosine - rat
    
  • 2mda – rMO regulatory domain
    

*Nitronate monooxygenase

• • 4q4k – PaMO + FMN
    
  • 6e2a – PaMO + FMN + NAD
    
  • 5lsm – MO + FMN – Shewanella oneidensis
    
  • 6bka – MO + FMN – Cyberlyndnera mrakii
    

*2-hydroxbiphenyl 3-monooxygenase

• • 4z2r – PnMO + FAD – Pseudomonas nitroreducens
    
  • 4cy6 – PnMO (mutant)
    
  • 4z2u, 4z2t, 4cy8, 6em0 – PnMO (mutant) + FAD
    
  • 5brt – PnMO + FAD + hydroxybephenyl
    

*4-hydroxyphenylacetate 3-monooxygenase

• • 4ira – BmMO + FAD – Brucella melitensis
    
  • 3cb0 – BmMO + FMN
    
  • 6eb0 – EcMO oxygenase subunit
    
  • 6b1b – EcMO oxygenase subunit (mutant)
    

*Ornithine N(5)-monooxygenase

• • 6x0i – NfMO + FAD + NADP – Neosartorya fumigata
    
  • 5cku – NfMO + FAD + NADP + ornithine
    
  • 6x0h – AfMO (mutant) + FAD – Aspergillus fumigatus
    
  • 4nzh, 4b69 – AfMO + FAD + ornithine
    
  • 6x0k – AfMO (mutant) + FAD + ornithine
    
  • 4b65 – AfMO + FAD + NADP
    
  • 4b68, 4b66 – AfMO + FAD + NAP + arginine
    
  • 4b67, 4b63 – AfMO + FAD + NADP + ornithine
    
  • 6x0j – AfMO (mutant) + FAD + NADP + ornithine
    
  • 4b64 – AfMO + FAD + NADP + lysine
    
  • 3s61 – PaMO + FAD + NADP + ornithine derivative
    

*Steroid monooxygenase

• • 4ap1, 4aos – RrMO + FAD + NADP – Rhodococcus rhodochrous
    
  • 4aox – RrMO (mutant) + FAD
    
  • 4ap3 – RrMO (mutant) + FAD + NADP
    

*Cyclohexanone monooxygenase

• • 5m10 – TmMO + FAD + NAP + nicotinamide – Thermocripsum municipale
    
  • 5m0z – TmMO + FAD + NADP derivative
    
  • 6gqi – TmMO + FAD + NADP + hexanic acid
    
  • 6era, 6er9 – RhMO + FAD + NADP – Rhodococcus
    
  • 4rg4, 4rg3, 3gwf, 3gwd – RhMO + FAD + NAP + caprolactone
    
  • 3ucl – RhMO + FAD + NADP + cyclohexanone
    

*Lysine 6-monooxygenase

• • 5cqf – MO – Pseudomonas syringae
    
  • 4d7e – NfMO (mutant) + FAD – Nocardia farcinica
    
  • 5o8p – EaMO + FAD – Erwinia amylovora
    
  • 5o8r – EaMO + FAD + NADP
    

*EDTA monooxygenase

• • 5dqp – MO – Chelativorans
    

*Rifampicin monooxygenase or Pentachlorophenol 4-monooxygenase

• • 5vqb – SvMO + FAD – Sterptomyces venezuelae
    
  • 6brd – SvMO (mutant) + FAD + rifampicin
    
  • 5kow – NfMO + FAD
    
  • 5kox – NfMO + FAD + rifampicin
    

*3,6-diketocamphane 1,6 monooxygenase

• • 5aec – PpMO
    
  • 4uwm – PpMO + FMN
    

*4-hydroxybenzoate 3 monooxygenase

• • 6ju1 – PaMO (mutant) + dihydroxybenzoate
    

*FAD monooxygenase

• • 6pvg – PfMO + FAD – Penicillium fellutamanum
    
  • 6pvf, 6pvj – PfMO + FAD + malbrancheamide
    
  • 6pvh. 6pvi – PfMO + FAD + paraherquamide
    

*Lytic polysaccharide monooxygenase

• • 5tki, 5foh, 4qi8 – NcMO-2 + Cu – Neurospora crassa'Italic text
    
  • 5tkh, 5tkg, 5tkf, 4eir – NcMO-2 + Cu + O2
    
  • 4eis – NcMO-3 + Cu + peroxide
    
  • 5iju – MO + Cu – Bacillus amyloliquefaciens
    
  • 5acj, 5aci, 5ach, 5acg, 5acf – MO + Cu – Lentinus similis
    
  • 4mai – moMO + Cu – mold
    
  • 4mah – moMO + Zn
    
  • 5no7 – MO – Pycnoporus cinnabarinus
    
  • 6ndq – MO – Kitsatospora papulosa
    

*Peptidyl-glycine alpha-amidating monooxygenase

• • 5mw0, 5wkw – rMO
    
  • 1yjl – rMO (mutant)
    
  • 3mib, 3mic, 3mid, 3mie, 3mif, 3mig, 3mih, 3mlj, 3mlk, 3mll, 1opm – rMO + Cu + Ni
    
  • 6ao6, 5wja, 6nck – rMO (mutant) + Cu + Ni
    
  • 1sdw – rMO + Cu + Ni + O2 + threonine derivative
    
  • 1yjk, 1yip, 1phm – rMO + Cu
    
  • 1yi9, 6ay0, 6an3, 6amp, 6alv, 6ala – rMO (mutant) + Cu
    
  • 3fw0 – rMO + Hg
    
  • 3fvz – rMO + Zn + Fe
    

*Antibiotic biosynthesis monooxygenase

• • 4hl9 – MO – Rhodospirillum rubrum
    
  • 4dn9 – MO – Chloroflexus aurantiacus
    
  • 2ril – MO – Shewanella loihica
    

*Monooxygenase

• • 2i7g – MO – Agrobacterium tumefaciens
    
  • 5uq4 – MtMO
    
  • 5f5l – MiMO – Micromonospora
    
  • 5f5n – MiMO + NAD + substrate
    

*Monooxygenase TROPB

• • 6nes – TsMO + FAD – Talaromyces stipitatus
    
  • 6nev, 6neu – TsMO (mutant) + FAD
    
  • 6net – TsMO + FAD + dihydroxy dimethylbenzaldehyde
    

*Lactate 2-monooxygenase or lactate oxydase

• • 6dvi – MsLMO + FMN – Mycobacterium smegmatis
    
  • 6dvh – MsLMO (mutant) + FMN
    

*Squalene monooxygenase or squalene epoxidase

• • 6c6r, 6c6p, 6c6n – hSMO + FAD + inhibitor
    

*Dimethyl-sulfide monooxygenase

• • 6ak1 – DMOA – Hyphomicrobium sulfonivorans
    

Salicylate 1-monooxygenase or salicylate hydroxylase See Hydroxylase

Methane monooxygenase See Methane monooxygenase Camphor 5-monooxygenase See Cytochrome P450 Luciferin 4-monooxygenase and Alkanal monooxygenase See Luciferase Phenylalanine 4-monooxygenase or phenylalanine-4-hydroxylase See Hydroxylase