Rho guanine nucleotide exchange factor

Function Rho guanine nucleotide exchange factor (GEF) stimulate the exchange of the inactive GDP-bound GTPase to its active GTP-bound form. Binding of GEF to GDP-GTPase catalyzes the dissociation of GDP from the protein. GEF domains include the catalytic DH/PH (Dbl Homology/Pleckstrin Homology) domain; the CH (Calponin Homology) domain is believed to be involved in calcium regulation; the SH3 domain interacts with proline-rich sequences. Rho guanine nucleotide exchange factor 1 binds to G proteins and stimulate Rho-dependent signals. Rho guanine nucleotide exchange factor 6 acts on RAC1. Disease Increased GEF activity is involved in cancer cell proliferation by affecting Rho GTPases .

spinqualitylabelsall models Human Rho guanine nucleotide exchange factor 11 DH/PH domain (grey) complex with transforming protein RhoA (cyan), GSP and Mg+2 ion (green) (PDB code 3kz1) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of Rho guanine nucleotide exchange factor3D Structures of Rho guanine nucleotide exchange factor

Updated on 06-September-2018

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• Rho guanine nucleotide exchange factor 1 (P115-RhoGEF)
  • 1iap – hGEF N terminal - human
    
  • 3odo, 3odw, 3odx – hGEF DH/PH domain
    
  • 3p6a – hGEF DH/PH domain (mutant)
    
  • 1shz, 3ab3 – hGEF N terminal + guanine nucleotide-binding protein
    
• Rho guanine nucleotide exchange factor 2
  • 5efx - hGEF residues 439-582
    
• Rho guanine nucleotide exchange factor 4 (Asef)
  • 2dx1, 2pz1 – hGEF
    
  • 3nmx, 3nmz – hGEF + APC variant protein
    
• Rho guanine nucleotide exchange factor 6
  • 1ujy – hGEF SH3 domain - NMR
    
  • 1wyr – hGEF CH domain - NMR
    
• Rho guanine nucleotide exchange factor 7 (β-PIX)
  • 1by1 – hGEF DH domain - NMR
    
  • 2l3g – hGEF CH domain - NMR
    
  • 2esw – GEF SH3 domain – mouse
    
  • 2g6f – rGEF SH3 domain – rat
    
  • 2w6b – rGEF coiled-coil domain
    
• Rho guanine nucleotide exchange factor 7 complex with peptide
  • 2ak5 – hGEF SH3 domain + CBL-b peptide
    
  • 2df6 – hGEF SH3 domain + PAK-1 peptide
    
  • 1zsg – hGEF residues 179-243 + PAK-1 peptide – NMR
    
  • 5sxp - hGEF residues 183-243 + E3 ubiquitin-protein ligase itchy
    
  • 2p4r – rGEF SH3 domain + E3 ubiquitin protein ligase peptide
    
  • 3l4f – rGEF coiled-coil domain + SHANK1 PDZ domain
    
• Rho guanine nucleotide exchange factor 8 (PRONE8)
  • 2ntx – AtGEF PRONE domain – Arabidopasis thaliana
    
  • 2wbl – AtGEF PRONE domain + GTPase ROP7
    
  • 2nty – AtGEF PRONE domain + GTPase ROP4 + GDP
    
  • 3eo2 – hGEF residues 161-373
    
  • 4xh9 – hGEF DH/PH domain + transforming protein RhoA
    
• Rho guanine nucleotide exchange factor 9 (collybistin)
  • 2ysq – hGEF SH3 domain - NMR
    
  • 4mt6, 4mt7 – rGEF (mutant)
    
  • 2dfk – rGEF + CDC42
    
• Rho guanine nucleotide exchange factor 11
  • 2dls – hGEF PDZ domain - NMR
    
  • 5tyt - hGEF PDZ domain/CXCR2 peptide
    
  • 3kz1, 3t06, 5jhg, 5jhh – hGEF DH/PH domain + transforming protein RhoA
    
  • 1xcg – hGEF DH/PH domain + transforming protein RhoA - NMR
    
  • 3cx6 – rGEF RGS domain + guanine nucleotide-binding protein
    
  • 5e6p - mGEF PDZ domain + plexin-B2
    
• Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF)
  • 1txd – hGEF DH/PH domain
    
  • 2omj – hGEF PDZ domain
    
  • 1x86 – hGEF DH/PH domain (mutant) + transforming protein RhoA
    
  • 2os6 – hGEF PDZ domain + plexin peptide – NMR
    
• Rho guanine nucleotide exchange factor 16
  • 1x6b – hGEF SH3 domain - NMR
    
• GEF guanine nucleotide exchange factor 18
  • 6bcb – mGEF + transforming protein RhoA
    
• GEF guanine nucleotide exchange factor 28
  • 6bc1 – hGEF + Ras-related C3 botulinum toxin substrate 1
    
  • 6bc0 – hGEF + transforming protein RhoA