6bc0

A Complex between PH Domain of p190RhoGEF and Activated RhoA Bound to a GTP AnalogA Complex between PH Domain of p190RhoGEF and Activated RhoA Bound to a GTP Analog

Structural highlights 6bc0 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.198Å Ligands: , Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function ARG28_HUMAN Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). See Also Rho GTPase 3D structures Rho guanine nucleotide exchange factor 3D structures

spinqualitylabelsall models 6bc0, resolution 2.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image