2ysq

Solution structure of the SH3 domain from Rho guanine nucleotide exchange factor 9Solution structure of the SH3 domain from Rho guanine nucleotide exchange factor 9

Structural highlights 2ysq is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Solution NMR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN Disease ARHG9_HUMAN Defects in ARHGEF9 are the cause of pileptic encephalopathy, early infantile, type 8 (EIEE8) [MIM:300607. A disorder characterized by hyperekplexia and early infantile epileptic encephalopathy. Neurologic features include exaggerated startle response, seizures, impaired psychomotor development, and mental retardation. Seizures can be provoked by tactile stimulation or extreme emotion. Function ARHG9_HUMAN Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See Also Rho guanine nucleotide exchange factor 3D structures

spinqualitylabelsall models 2ysq Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image