Transcription initiation factor

Transcription initiation factors (TFII) are proteins which enable RNA polymerase II to bind to the DNA template in order to start the transcription process. TFIID recognizes the promoter sequence on the DNA while TFIIB bridges between TFIID and RNA polymerase II. TFIIA is one of several TFs which are required for transcription. TFIIA aids in binding the TATA-binding protein (TBP) to the TATA box containing sequence of the DNA. 3D structures of transcription initiation factors TFIIA 1ytf – TFIIA + TBP + DNA – yeast TFIIB 1pft – TFIIB N terminal – Pyrococcus furiosus – NMR 1tfb – hTFIIB – human - NMR 1vol, 1c9b – hTFIIB + TBP + DNA 1ais, 1d3u - TFIIB C terminal + TBP + DNA – Pyrococcus woesei TFIID 1bh8 – hTFIID 1tba – TFIID – Drosophila melanogaster - NMR 1bh9 – hTFIID + PCMBS 1qn3, 1qn4, 1qn5, 1qn6, 1qn7, 1qn8, 1qn9, 1qna, 1qnb, 1qnc – TFIID + DNA – Arabidopsis thaliana

spinqualitylabelsall models Structure of human TFIIB (grey) complex with TATA-binding protein (green) and DNA (PDB entry 1vol) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image