Transcription initiation factor

Transcription initiation factors (TFII) are proteins which enable RNA polymerase II to bind to the DNA template in order to start the transcription process. TFIIA is one of several TFs which are required for transcription. TFIIA aids in binding the TATA-binding protein (TBP) to the TATA box containing sequence of the DNA. TFIIB bridges between TFIID and RNA polymerase II. TFIID recognizes the promoter sequence on the DNA. TFIIF binds RNA polymerase III prohibiting it to bind to DNA outside the promoter.

spinqualitylabelsall models Structure of human TFIIB (grey) complex with TATA-binding protein (green) and DNA (PDB entry 1vol) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of transcription initiation factors3D structures of transcription initiation factors

Updated on 21-June-2015

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• TFIIA
  • 1ytf, 1nh2, 1rm1 – yTFIIA + TBP + DNA – yeast
    
  • 1nvp – hTFIIA + TATA-binding protein + DNA – human
    
• TFIIB
  • 1pft – TFIIB N terminal – Pyrococcus furiosus – NMR
    
  • 1tfb – hTFIIB - NMR
    
  • 1dl6 - hTFIIB N terminal – NMR
    
  • 1rly - hTFIIB Zn ribbon domain + Zn – NMR
    
  • 1ro4 - hTFIIB Zn ribbon domain – NMR
    
  • 1vol, 1c9b – hTFIIB + TBP + DNA
    
  • 3k1f, 3k7a, 4bbr, 4bbs – yTFIIB + RNA polymerase II
    
  • 4v1o, 4v1n – yTFIIB + yTFIIF + RNA polymerase II – Cryo EM
    
  • 1ais, 1d3u - TFIIB C terminal + TBP + DNA – Pyrococcus woesei
• TFIID
  • 1bh8 – hTFIID
    
  • 1eqf – hTFIID subunit 1
    
  • 3uv5, 3uv4 – hTFIID subunit 1 bromodomain
    
  • 3aad – hTFIID subunit 1 bromodomain + histone chaperone ASF1A
    
  • 4wv4 - hTFIID subunits 8+10
    
  • 4grw - hTFIID subunits 1+7
    
  • 4oy2 - yTFIID subunits 1+7
    
  • 1tba – TFIID – Drosophila melanogaster - NMR
    
  • 1bh9 – hTFIID + PCMBS
    
  • 1qn3, 1qn4, 1qn5, 1qn6, 1qn7, 1qn8, 1qn9, 1qna, 1qnb, 1qnc, 1qne – TFIID + DNA – Arabidopsis thaliana
• TFIIE
  • 1vd4 - hTFIIB Zn finger domain – NMR
    
  • 2rnq – hTFIIE C terminal - NMR
    
  • 2rnr – hTFIIE C terminal + TFIIH PH domain- NMR
    
• TFIIF
  • 1f3u – hTFIIF
    
  • 1nha – hTFIIF C terminal - NMR
    
  • 1i27 – hTFIIF C terminal (mutant)
    
  • 1j2x – hTFIIF C terminal + RNA polymerase CTD phosphatase peptide
    
  • 1onv – hTFIIF C terminal + serine phosphatase peptide - NMR
    
  • 2k7l – hTFIIF C terminal + FCP1 peptide - NMR