Cyclin-dependent kinase 3D structures

3D structures of cyclin-dependent kinase3D structures of cyclin-dependent kinase

Updated on 17-February-2025

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• CDK1
  • 1dks – hCDK1 + phosphate - human
    
  • 1dkt – hCDK1 + vanadate
    
  • 4yc6 – hCDK1 + CDK regulatory subunit 1
    
  • 4y72, 4yc3, 5hq0 – hCDK1 + CDK regulatory subunit 2 + cyclin B1
    
  • 6gu6, 6gu7 – hCDK1 + CDK regulatory subunit 2 + inhibitor
    
  • 5lqf, 6gu4, 6gu3, 6gu2 – hCDK1 + CDK regulatory subunit 2 + cyclin B1 + inhibitor
    
  • 7nj0 – hCDK1 + cyclin B1 + CDK regulatory subunit 1 + separin – Cryo EM
    
• CDK2
  • 1pw2, 1hck, 1hcl, 1b38, 4ek3, 5ano, 8ru8 – hCDK2
    
  • 6yl6 - hCDK2 (mutant)
    
  • 1b39 - hCDK2 T160P
    
  • 1aq1, 1ckp, 1di8, 1dm2, 1e1v, 1e1x, 1fvt, 1fvv, 1g5s, 1gih, 1gii, 1gij, 1gz8, 1h00, 1h01, 1h07, 1h08, 1h0v, 1h0w, 1jsv, 1jvp, 1ke5, 1ke6, 1ke7, 1ke8, 1ke9, 1oiq, 1oir, 1oit, 1p2a, 1pf8, 1pxi, 1pxj, 1pxk, 1pxl, 1pxn, 1pxo, 1pxp, 1pye, 1r78, 1urw, 1v1k, 1vyw, 1vyz, 1w0x, 1w8c, 1wcc, 1y8y, 1y91, 2a0c, 2a4l, 2b52, 2b53, 2b54, 2b55, 2bhe, 2bhh, 2bpm, 2btr, 2bts, 2c68, 2c69, 2c6i, 2c6k, 2c6l, 2c6m, 2c6o, 2c6t, 2clx, 2duv, 2exm, 2fvd, 2j9m, 2r3f, 2r3g, 2r3h, 2r3i, 2r3j, 2r3k, 2r3l, 2r3m, 2r3n, 2r3o, 2r3p, 2r3q, 2r3r, 2r64, 2v0d, 2vta, 2vth, 2vti, 2vtj, 2vtl, 2vtm, 2vtn, 2vto, 2vtp, 2vtq, 2vtr, 2vts, 2vtt, 2vu3, 2vv9, 2w05, 2w06, 2w17, 2w1h, 2xmy, 2xnb, 3ezr, 3ezv, 3fz1, 3ig7, 3igg, 3le6, 3lfn, 3lfq, 3lfs, 3ns9, 3pj8, 3pxf, 3pxq, 3pxr, 3pxy, 3pxz, 3py0, 3py1, 3ql8, 3qqf, 3qqg, 3qqh, 3qqj, 3qqk, 3qrt, 3qru, 3qtq, 3qtr, 3qts, 3qtu, 3qtw, 3qtx, 3qtz, 3qu0, 3qwj, 3qwk, 3qx2, 3qx4, 3qxo, 3qxp, 3qzf, 3qzg, 3qzh, 3qzi, 3r1q, 3r1s, 3r1y, 3r28, 3r6x, 3r71, 3r73, 3r7e, 3r7i, 3r7u, 3r7v, 3r7y, 3r83, 3r8l, 3r8m, 3r8p, 3r8u, 3r8v, 3r8z, 3r9d, 3r9h, 3r9n, 3r9o, 3rah, 3rai, 3rak, 3ral, 3rjc, 3rk5, 3rk7, 3rk9, 3rkb, 3rm6, 3rm7, 3rmf, 3rni, 3roy, 3rpo, 3rpr, 3rpv, 3rpy, 3rzb, 3s00, 3s0o, 3s1h, 3s2p, 3sqq, 3sw4, 3sw7, 3ti1, 3tiy, 3tiz, 3uli, 3unj, 3unk, 3wbl, 4acm, 4bgh, 4ek4, 4ek5, 4ek6, 4ek8, 4ez3, 4ez7, 4fkg, 4fki, 4fkj, 4fkl, 4fko, 4fkp, 4fkq, 4fkr, 4fks, 4fkt, 4fku, 4fkv, 4fkw, 4gcj, 4kd1, 4lyn, 4nj3, 4bzd, 4rj3, 3qql, 5osj, 5oo0, 5mhq, 5k4j, 5jq8, 5jq5, 5iey, 5iex, 5fp6, 5fp5, 5d1j, 5ank, 5anj, 5ani, 5ang, 5ane, 5and, 5a14, 4d1z, 4d1x, 6guk, 6guh, 6inl, 6jgm, 6oqi, 7m2f, 7ra2, 7ra5, 7rwe, 7rwf, 7rxo,7s4t, 7s7a, 7s84, 7s85, 7s9x, 7sa0, 7ug1, 7vdu, 7zpc, 7zpx, 8cur, 8erd, 8ern, 8oy2, 8uv0, 9fr2 – hCDK2 + inhibitor
    
  • 2ds1, 5osm, 5oo3, 5oo1, 6yl1, 6ylk – hCDK2 (mutant) + inhibitor
    
  • 6q3b, 6q3c, 6q3f, 6q48, 6q49, 6q4a, 6q4b, 6q4c, 6q4d, 6q4e, 6q4f, 6q4g, 6q4h, 6q4i, 6q4j, 6q4k – hCDK2 + fraglite
    
  • 5iev – hCDK2 + drug
    
  • 8fow, 8fp0 – hCDK2 + drug + inhibitor
    
  • 8fp5 – hCDK2 + ATP
    
  • 1fq1 - hCDK2 +cyclin-dependent kinase inhibitor 3
    
  • 5uq3 - hCDK2 + speedy protein A + cyclin-dependent kinase inhibitor 3
    
  • 5uq2, 5uq1 - hCDK2 + speedy protein A
    
  • 7e34 - hCDK2 + speedy protein A + SUN1
    
  • 1buh – hCDK2+ protein CKSHS1
    
  • 4erw, 7nvq – hCDK2 + staurosporine
    
  • 7uxi, 7uxk, 8umy – hCDK2+ polypeptide
    
• CDK2+cyclin
  • 5if1, 6sg4 – hCDK2 + cyclin A2
    
  • 8roz – hCDK2 + cyclin A2 + CDC25A – Cryo EM
    
  • 2jgz - hCDK2 T160P + cyclin B1
    
  • 1w98, 5l2w, 7kjs - hCDK2 + cyclin E1
    
  • 8h6p, 8h6t, 8vq3, 8vq4 - hCDK2 + cyclin E1 + inhibitor
    
  • 1gy3, 1h24, 1h25, 1h26, 1h27, 1h28, 1okv, 1okw, 1ol1, 1ol2, 1urc, 2cch, 2v22, 2wev, 2wfy, 2whb, 2wma, 2wmb, 2x1n, 3qhr, 3qhw, 6p3w - hCDK2 + cyclin A2+peptide ligand
    
  • 1fin, 1p5e, 1pkd, 1ykr, 2bkz, 2c5n, 2c5o, 2c5v, 2c5x, 2c5y, 2c4g, 2i40, 2uue, 2uzb, 2uzd, 2uze, 2uzl, 2uzn, 2uzo, 2wih, 2wip, 2wpa, 2wxv, 3f5x, 3eoc, 3eid, 3ej1, 4bcm, 4bcn, 4bco, 4bcp, 4bcq, 4cfm, 4cfn, 4cfu, 4cfv, 4cfw, 4cfx, 4fx3, 6gva, 6guf, 6gue, 6guc, 6rij, 7ack, 7b7s, 7mkx, 7qhl, 8b54 – hCDK2 + cyclin A2 + inhibitor
    
  • 6ath - hCDK2 T160P+ cyclin A2 + CDK inhibitor 1B
    
  • 1h1p, 1h1q, 1h1r, 1h1s, 1jst, 1ogu, 1oi9, 1oiu, 1oiy, 2cjm, 2g9x, 2iw6, 2iw8, 2iw9, 3bht, 3bhu, 3bhv, 3ddp, 3ddq, 3dog, 3tnw, 4bck, 4eoi, 4eoj, 4eok, 4eol, 4eom, 4eon, 4eoo, 4eop, 4eoq, 4eor, 4eos, 5cyi, 5nev, 5lmk - hCDK2 T160P+ cyclin A2 + inhibitor
    
  • 8bzo - hCDK2 T160P + hCYCA2 + p27 – Cryo EM
  • 2cci, 1qmz - hCDK2 T160P + cyclin A2+peptide ligand
    
  • 1e9h - hCDK2 T160P + cyclin A3 + inhibitor
    
  • 1jsu - hCDK2 T160P + cyclin A2+ protein P27
    
  • 4i3z, 4ii5 - hCDK2 T160P + cyclin A2+ ADP
    
  • 1f5q - hCDK2 + g herpesvirus cyclin
    
  • 7b5r - hCDK2 + cyclin A + cullin1 + RBX1 + SKP1 + SKP2 + CKSHS1 + p27 – cryo EM
    
  • 8bya - hCDK2 + cyclin A + SKP1 + SKP2 + CKS1 + p27 – cryo EM
    
  • 7b5m - hCDK2 + cyclin A + cullin1 + RBX1 + SKP1 + SKP2 + CKSHS1 + p27 + ARIH1 + Ub – cryo EM
    
  • 7b5l - hCDK2 + cyclin A + cullin1 + RBX1 + SKP1 + SKP2 + CKSHS1 + p27 + NEDD8 + ARIH1 + UBE2L3 + Ub – cryo EM
    
• CDK3
  • 1fpz – hCDK3 (mutant)
  • 7xqk – hCDK3 + hCYCE1
    
  • 8h4r – hCDK3 + hCYCE1 + drug
    
• CDK4
  • 2w96, 2w99, 2w9f, 2w9z – hCDK4 kinase domain + cyclin D1
    
  • 6p8e, 6p8f, 6p8g, 6p8h – hCDK4 (mutant) + cyclin D1 + CDK inhibitor 1B
    
  • 3g33 - hCDK4 + cyclin D3
    
  • 7sj3 - hCDK4 + cyclin D3 + drug
    
  • 5fwp, 5fwm, 5fwl, 5fwk - hCDK4-P + HSP 90 + CDC37 – cryo-EM
    
• CDK5
  • 1h4l – hCDK5 + CDK5 activator
    
  • 1ung, 1unh, 1unl - hCDK5 (mutant) + CDK5 activator + inhibitor
    
  • 4au8 – hCDK5 + inhibitor
    
  • 3o0g - hCDK5 + ATP analog + CDK5 activator
    
  • 7vdp, 7vdq, 7vdr, 7vds – hCDK5 + p25 + inhibitor
    
• CDK6
  • 1bi7 – hCDK6 + multiple tumor suppressor
    
  • 1bi8, 1blx – hCDK6 + CDK protein inhibitor
    
  • 1g3n – hCDK6 + cyclin D homolog + CDK protein inhibitor
    
  • 1jow – hCDK6 + V-cyclin
    
  • 3nup, 3nux, 4aua, 4ez5, 6oql, 6oqo, 8i0m – hCDK6 + inhibitor
    
  • 5l2t, 5l2s, 5l2i – hCDK6 + drug
    
  • 1xo2, 2f2c, 2euf, 4tth – hCDK6 + V-cyclin + inhibitor
    
• CDK7
  • 1ua2 – hCDK7
    
  • 8r99, 8r9a, 8r9b, 8r9o, 8r9s, 8r9u – hCDK7 + AMPPNP
    
  • 8p4z – hCDK7 + inhibitor
    
  • 6o9l – hCDK7 in transcription preinitiation complex – Cryo EM
    
  • 8pyr – hCDK7 + cyclin H + MAT1
    
  • 6xbz, 7b5o, 7b5q, 8orm, 8p6w, 8p6x, 8p73, 8p74, 8p75, 8p79 – hCDK7 + cyclin H + MAT1 – Cryo EM
    
  • 8p7l – hCDK7 + MAT1 + inhibitor – Cryo EM
    
  • 6xd3, 8p6v, 8p6z, 8p70, 8p71, 8p72, 8p76, 8p77, 8plz, 8s0r, 8s0t – hCDK7 + cyclin H + MAT1 + inhibitor – Cryo EM
    
  • 8p78 – hCDK7 + cyclin H + MAT1 + drug – Cryo EM
    
  • 8p6y – hCDK7 + hCYCH + MAT1 + ATPgS – Cryo EM
    
  • 7nvr – hCDK7 + hCYCH in DNA polymerase complex – Cryo EM
    
• CDK8
  • 4g6l, 4crl – hCDK8 + cyclin C
    
  • 3rgf, 4f6s, 4f6u, 4f6w, 4f70, 4f7j, 4f7l, 4f7n, 4c4l, 5bnj, 5cei, 5fgk, 5hbe, 5hbh, 5hbj, 5hnb, 5hvy, 5i5z, 5icp, 5idn, 5idp, 5xs2, 5xqx, 4f7s, 6qtg, 6qtj, 6r3s, 6t41, 6y0a, 9h8c, 9h8s – hCDK8 + cyclin C + inhibitor
    
  • 6tpa – hCDK8 + cyclin C + drug
    
  • 8tq2, 8tqc – hCDK8 + hCYCC + mediator of RNA polymerase transcription subunit 12,13 – Cryo EM
    
  • 8tqw – hCDK8 + hCYCC + mediator of RNA polymerase transcription complex– Cryo EM
    
• CDK9
  • 3blh, 4ec8, 4ec9 – hCDK9-P + cyclin T1 (mutant)
    
  • 3blq – hCDK9-P + cyclin T1 (mutant) + ATP
    
  • 3lq5, 3my1, 3tn8, 3tnh, 3tni, 4bcf, 4bcg, 4bch, 4bci, 4bcj, 6gzh, 6w9e, 6z45, 7nwk, 8i0l, 8k5r – hCDK9-P + cyclin T1 (mutant) + inhibitor
    
  • 3blr – hCDK9-P + cyclin T1 + flavopiridol
    
  • 3mi9, 3mia – hCDK9-P + cyclin T1 + HIV-1 TAT
    
  • 5l1z, 6cyt – hCDK9-P + cyclin T1 + HIV-1 TAT + AF4/FMR2 + RNA
    
  • 4or5, 4ogr – hCDK9-P + cyclin T1 + HIV-1 TAT + major CDK9 elongation factor-associated protein
    
  • 4imy – hCDK9-P + cyclin T1 + CDK9 elongation factor-associated protein
    
• CDK11
  • 7ukz – hCDK11b-P + inhibitor
    
• CDK12 kinase domain
  • 4un0 – hCDK12-P + cyclin K
    
  • 4nst – hCDK12-P + cyclin K + AlF3
    
  • 4cxa – hCDK12-P + cyclin K + AMPPNP
    
  • 6b3e, 5acb, 6b3p, 6ckx, 7nxk, 8p81 – hCDK12-P + cyclin K + inhibitor
    
  • 6td3, 8bu1, 8bu2, 8bu3, 8bu4, 8bu5, 8bu6, 8bu7, 8bu9, 8bua, 8bub, 8buc, 8bud, 8bue, 8buf, 8bug, 8buh, 8bui, 8buj, 8buk, 8bul, 8bum, 8bun, 8buo, 8bup, 8buq, 8bur, 8bus, 8but, 9fmr - hCDK12-P + cyclin K + DDB1 + inhibitor
    
• CDK13
  • 5efq – hCDK13-P residues 694-1039 + cyclin K + ADP
    
• CDK16
  • 3mtl, 5g6v – hCDK16 (mutant) + indirubin