8buo

Structure of DDB1 bound to DS24-engaged CDK12-cyclin KStructure of DDB1 bound to DS24-engaged CDK12-cyclin K

Structural highlights

8buo is a 9 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 3.58Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CCNK_HUMAN May play a role in transcriptional regulation. In vitro, is associated with a kinase activity toward both RNA polymerase II C-terminal domain and CDK2 (CAK).^[1]

References

↑ Fu TJ, Peng J, Lee G, Price DH, Flores O. Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription. J Biol Chem. 1999 Dec 3;274(49):34527-30. PMID:10574912

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OCA

[1] Fu TJ, Peng J, Lee G, Price DH, Flores O. Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription. J Biol Chem. 1999 Dec 3;274(49):34527-30. PMID:10574912

[1]

8buo

Structure of DDB1 bound to DS24-engaged CDK12-cyclin KStructure of DDB1 bound to DS24-engaged CDK12-cyclin K

Structural highlights

Function

References

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8buo

Structure of DDB1 bound to DS24-engaged CDK12-cyclin KStructure of DDB1 bound to DS24-engaged CDK12-cyclin K

Structural highlights

Function

References

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