Progestogens: Difference between revisions

Latest revision as of 16:57, 14 November 2021

Progesterone

(P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species.

Progesterone is a negative allosteric modulator of nicotinic acetylcholine receptors, and a potent antagonist of the mineralocorticoid receptor.

Hydroxysteroid dehydrogenase, 20-α HSD is involved in the control of progesterone level in pregnancy of mice. 17-β HSD is involved in the conversion of androstenedione to testosterone.

Structure of human progesterone receptor ligand-binding domain complex with RU486 and sulfate (PDB entry 2w8y)

Drag the structure with the mouse to rotate

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 <StructureSection load='2w8y' size='300' side='right' caption='Structure of human progesterone receptor ligand-binding domain complex with RU486 and sulfate (PDB entry [[2w8y]])' scene='78/780972/Cv/2'>
 '''Progesterone'''
-*[[Progesterone receptor]]
-Progesterone is a negative allosteric modulator of [[nicotinic acetylcholine receptors]], and a potent antagonist of the [[mineralocorticoid receptor]].
+<scene name='89/895670/Cv/7'>Progesterone</scene> (P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species.
+*[[Progesterone receptor]]. <scene name='89/895670/Cv/8'>Human progesterone receptor ligand-binding domain bound with progesterone</scene> ([[1a28]]). Water molecules are shown as red spheres.
+*Progesterone is a negative allosteric modulator of [[nicotinic acetylcholine receptors]], and a potent antagonist of the [[mineralocorticoid receptor]].
 *[[Hydroxysteroid dehydrogenase]], 20-α HSD is involved in the control of progesterone level in pregnancy of mice. 17-β HSD is involved in the conversion of androstenedione to testosterone.