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| Line 9: |
Line 9: |
| **[[6kde]] – hIDH3 α,β subunits + Ca <br /> | | **[[6kde]] – hIDH3 α,β subunits + Ca <br /> |
| **[[5grh]] – hIDH3 α,γ subunits + Mg <br /> | | **[[5grh]] – hIDH3 α,γ subunits + Mg <br /> |
| | **[[7ce3]] – hIDH3 α,β,γ subunits<br /> |
| **[[3blx]] – yIDH - yeast<br /> | | **[[3blx]] – yIDH - yeast<br /> |
| **[[2uxq]] – DpIDH – ''Desulfotalea psychrophila''<br /> | | **[[2uxq]] – DpIDH – ''Desulfotalea psychrophila''<br /> |
| Line 25: |
Line 26: |
| **[[5m2e]] - PaIDH – ''Pseudomonas aeruginosa''<br /> | | **[[5m2e]] - PaIDH – ''Pseudomonas aeruginosa''<br /> |
| **[[6ixl]] – OtIDH – ''Ostreococcus tauri''<br /> | | **[[6ixl]] – OtIDH – ''Ostreococcus tauri''<br /> |
| | **[[6lkz]] – IDH – ''Phaeodactylum tricomutum''<br /> |
| | **[[6ltf]], [[6m3s]] – IDH – ''Xanthomonas campestris''<br /> |
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| *IDH+citrate | | *IDH+citrate |
| Line 43: |
Line 46: |
| **[[1hqs]] – IDH+citrate – ''Bacillus subtilis''<br /> | | **[[1hqs]] – IDH+citrate – ''Bacillus subtilis''<br /> |
| **[[4zda]] - IDH +isocitrate+Mn – ''Mycobacterium smegmatis''<br /> | | **[[4zda]] - IDH +isocitrate+Mn – ''Mycobacterium smegmatis''<br /> |
| **[[7e2w]] - OtIDH +isocitrate+Mg<br /> | | **[[[6ixu]], [7e2w]] - OtIDH +isocitrate+Mg<br /> |
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| *IDH+NADP | | *IDH+NADP |
3D Structures of Isocitrate dehydrogenase3D Structures of Isocitrate dehydrogenase
Updated on 10-October-2021
{"openlevels":0}
- Isocitrate dehydrogenase
- 6kdf – hIDH3 α,β subunits - human
- 6kde – hIDH3 α,β subunits + Ca
- 5grh – hIDH3 α,γ subunits + Mg
- 7ce3 – hIDH3 α,β,γ subunits
- 3blx – yIDH - yeast
- 2uxq – DpIDH – Desulfotalea psychrophila
- 3dms – IDH – Burkholderia pseudomallei
- 2e0c, 2dht - StIDH – Sulfolobus tokodaii
- 2iv0 – IDH – Archaeoglobus fulgidus
- 1zor – IDH – Thermotoga maritima
- 2b0t – IDH – Corynebacterium glutamicum
- 1xgv, 1v94 - ApIDH – Aeropyrum pernix
- 1pb3, 1sjs, 6icd, 7icd, 3icd – EcIDH – Escherichia coli
- 1idd, 1idf, 4icd - EcIDH (mutant)
- 3ah3 – TtIDH – Thermus thermophilus
- 3us8 – IDH – Sinorhizobium meliloti
- 4aoy – CtIDH – Clostridium thermocellum
- 5z16 – IDH – Acinetobacter baumannii
- 5m2e - PaIDH – Pseudomonas aeruginosa
- 6ixl – OtIDH – Ostreococcus tauri
- 6lkz – IDH – Phaeodactylum tricomutum
- 6ltf, 6m3s – IDH – Xanthomonas campestris
- IDH+citrate
- 5yfn – hIDH1 + isocitrate+ Mg
- 5gri – hIDH3 α,γ subunits + citrate+ Mg
- 5h3f – mIDH 2 + isocitrate
- 5h3e – mIDH 2 (mutant) + isocitrate
- 2qfw – yIDH+isocitrate
- 3blv – yIDH+citrate
- 2uxr – DpIDH+isocitric acid
- 1itw – AvIDH+isocitrate+Mn – Azotobacter vinelandii
- 1lwd – IDH+isocitrate+Mn - pig
- 1pb1, 1p8f – EcIDH+isocitrate
- 1cw7, 5icd, 8icd - EcIDH +isocitrate+Mg
- 1cw1 - EcIDH (mutant)+isocitrate+Mn
- 1gro, 1grp, 4bnp - EcIDH (mutant)+isocitrate+Mg
- 1hqs – IDH+citrate – Bacillus subtilis
- 4zda - IDH +isocitrate+Mn – Mycobacterium smegmatis
- [[[6ixu]], [7e2w]] - OtIDH +isocitrate+Mg
- IDH+NADP
- 1t09, 5yfm – hIDH+NADP
- 3mar – hIDH (mutant) + NADP
- 5k10, 5k11 – hIDH + NADP – Cryo EM
- 5svn, 5svo – hIDH2 (mutant) + NADP
- 6kdy, 6ke3 – hIDH3 α,β + NADH
- 5yvt – hIDH α+γ + NADH
- 5yzh – mIDH+NADP – mouse
- 2qfv – yIDH+NADP
- 2e5m – StIDH+NADP
- 1tyo - ApIDH+NADP
- 1j1w – AvIDH+NADP – Azotobacter vinelandii
- 9icd - EcIDH +NADP
- 1iso - EcIDH (mutant)+NAD
- 3mbc - IDH (mutant)+NADP – Corynebacterium glutamicum
- 4hcx, 5kvu – IDH + NADP – mycobacterium tuberculosis
- 6aj6 – TbIDH (mutant) + NADP – Trypanosoma brucei
- 6ixt – OtIDH + NAD + Mg
- IDH+α-ketoglutarate
- 3inm, 4l03, 4l04, 4l06, 5i95 – hIDH1 (mutant)+NADPH+α-ketoglutarate+Ca
- 4kzo - hIDH1 +NADPH+α-ketoglutarate+Ca
- 2qfy - yIDH+α-ketoglutarate
- 2qfx - yIDH+NADPH+α-ketoglutarate+Ca
- 1cw4 – EcIDH (mutant)+α-ketoglutarate
- 1ika - EcIDH + α-ketoglutarate+Ca
- 4ajc - EcIDH (mutant) +α-ketoglutarate+A2P+Ca
- 4ajr - EcIDH (mutant) +α-ketoglutarate+ NADP+ Mg
- 1bl5 - EcIDH +α-ketoglutarate+NADP+Mg
- 6c0e - IDH +NADPH+ α-ketoglutarate – Legionella pneumophila
- 6g3u - PaIDH +NADPH+ α-ketoglutarate
- 6aj8, 6aja, 6ajb - TbIDH (mutant) +NADP + α-ketoglutarate
- IDH binary complex with inhibitor
- 6q6f – hIDH1 (mutant) + inhibitor
- 3asj – TtIDH + inhbibitor
- IDH higher complexes
- 3map, 6pay - hIDH1 +NADP+isocitrate
- 3mas – hIDH1 (mutant) +NADP+isocitrate
- 1t0l – hIDH+NADP+isocitrate+Ca
- 5gre, 5grf – hIDH3 α,γ subunits + ADP+ citrate+ Mg
- 5grl – hIDH3 α,γ subunits + ADP+ isocitrate+ Mg
- 5l57, 5l58 - hIDH1 +NADP + inhibitor
- 4i3k, 4i3l, 4ja8,4umx, 4umy, 4xrx, 4xs3, 5de1, 5lge, 5sun, 5svf, 6b0z, 5tqh, 6o2y, 6o2z, 6adg, 6u4j, 6vei, 6vg0 - hIDH1 (mutant) +NADP + inhibitor
- 6bkx, 6bky, 6bkz, 6bl0, 6bl1, 6bl2 – hIDH1 + isocitrate + inhibitor
- 6adi, 6vfz – hIDH2 (mutant) +NADP + inhibitor
- 6l57, 6l59 – hIDH3 a+g + citrate + ATP
- 6bkx, 6bky, 6bkz, 6bl0, 6bl1, 6bl2 - hIDH1 + isocitrate + inhibitor
- 5svf - hIDH (mutant) +NADP + citrate + inhibitor
- 5i96 – hIDH2 + NADP+ enasidenib + Ca
- 5yzi - mIDH+NADP+citrate
- 3blw – yIDH+citrate+AMP
- 2d4v – IDH+NAD+citrate – Acidithiobacillus thiooxidans
- 2d1c – TtIDH+NADP+citrate
- 1xkd – ApIDH+NADP+citrate
- 1idc - EcIDH (mutant)+oxalosuccinate+Mg
- 6ajc - TbIDH (mutant) +NADP+isocitrate
- 6ixn - OtIDH +NAD + citrate
- IDH quaternary complexes
- 5svf, 6io0 – hIDH1 (mutant) +NADP + citrate + inhibitor
- 1hj6 – EcIDH (mutant)+NADP+isopropylmalate+Mg
- 1ai3 - EcIDH +isocitrate+Mg+NDP
- 1ai2, 4aj3, 4aja - EcIDH +isocitrate+NADP+Ca
- 1ide, 4ajb - EcIDH (mutant)+isocitrate+Mg+NADP
- 4ajs - EcIDH (mutant)+isocitrate+Mg+ A2P + NMN
- 4p69 - EcIDH + IDH kinase/phosphatase + AMP + ADP
- 3lcb - EcIDH + IDH kinase/phosphatase + AMP + ATP
- 4aou - CtIDH + isocitrate+NADP+Mg
- 4aov - DpIDH + isocitrate+NADP+Mg