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| **[[2dkh]] – CtPHBH + FAD + hydroxy-benzoate <br /> | | **[[2dkh]] – CtPHBH + FAD + hydroxy-benzoate <br /> |
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| *Apartyl/asparaginyl β-hydroxylase; Domain – oxygenase and TPR 301-758 | | *Apartyl/asparaginyl β-hydroxylase; Domain – oxygenase and TPR 301-758 |
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| **[[6qa5]] – hAAH oxygenase and TPR domain<br /> | | **[[6qa5]] – hAAH oxygenase and TPR domain<br /> |
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Line 88: |
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| **[[6dax]], [[6alm]], [[6aln]], [[6mp8]] – SvAAH + arginine + oxoglutarate + Fe – ''Streptomyces vinaceus''<br /> | | **[[6dax]], [[6alm]], [[6aln]], [[6mp8]] – SvAAH + arginine + oxoglutarate + Fe – ''Streptomyces vinaceus''<br /> |
| **[[6daz]], [[6alo]], [[6alp]], [[6alq]] – SvAAH + arginine + succinate + Fe <br /> | | **[[6daz]], [[6alo]], [[6alp]], [[6alq]], [[6y12]] – SvAAH + arginine + succinate + Fe <br /> |
| | **[[6y0n]] – SvAAH + arginine + AKG + Fe <br /> |
| **[[6db2]], [[6alr]] – SvAAH + homoarginine + succinate + V <br /> | | **[[6db2]], [[6alr]] – SvAAH + homoarginine + succinate + V <br /> |
| **[[6mp9]] – SvAAH + guanidinopentanoate + succinate + Fe <br /> | | **[[6mp9]] – SvAAH + guanidinopentanoate + succinate + Fe <br /> |
| Line 120: |
Line 121: |
| **[[6daw]] – NAPI + Fe + Arg – ''Streptomyces lusitanus''<br /> | | **[[6daw]] – NAPI + Fe + Arg – ''Streptomyces lusitanus''<br /> |
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| *Prolyl 4-hydroxylase | | *Prolyl 4-hydroxylase |
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| **[[4bt8]], [[2yq8]] - hPH a1 subunit collagen-binding domain<br /> | | **[[4bt8]], [[2yq8]] - hPH a1 subunit collagen-binding domain<br /> |
| Line 133: |
Line 134: |
| **[[4p7w]] - RlPH + Co + proline<br /> | | **[[4p7w]] - RlPH + Co + proline<br /> |
| **[[6iuq]] - PH + Fe – ''Phytophthora capsici''<br /> | | **[[6iuq]] - PH + Fe – ''Phytophthora capsici''<br /> |
| **[[6ey1]] - TaPH + Mn – ''Trichoplax adhaerens''<br />
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| **[[6f0w]] - TaPH + Mn + hypoxia inducible factor + oxalylglycine <br />
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| **[[2v4a]], [[2jij]] - CrPH – ''Chlamydomonas reinhardtii'' <br /> | | **[[2v4a]], [[2jij]] - CrPH – ''Chlamydomonas reinhardtii'' <br /> |
| **[[2jig]] - CrPH + Zn + pyridine derivative<br /> | | **[[2jig]] - CrPH + Zn + pyridine derivative<br /> |
| Line 140: |
Line 139: |
| *HIF prolyl hydroxylase or egl nine homolog See [[Prolyl hydroxylase domain]] | | *HIF prolyl hydroxylase or egl nine homolog See [[Prolyl hydroxylase domain]] |
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| *Lysine 4-hydroxylase | | *Lysine 4-hydroxylase |
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| **[[6f9p]] – FlL4H + Fe – ''Flavobacterium'' <br /> | | **[[6f9p]] – FlL4H + Fe – ''Flavobacterium'' <br /> |
| Line 148: |
Line 147: |
| **[[6exh]] – FlL4H + Fe + lysine + succinate<br /> | | **[[6exh]] – FlL4H + Fe + lysine + succinate<br /> |
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| *Lysine 3-hydroxylase | | *Lysine 3-hydroxylase |
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| **[[6f2e]] – CaL3H – ''Catenulispora acidiphila'' <br /> | | **[[6f2e]] – CaL3H – ''Catenulispora acidiphila'' <br /> |
| Line 155: |
Line 154: |
| **[[6f6j]] – CaL3H + Fe + succinate + hydroxyl lysine <br /> | | **[[6f6j]] – CaL3H + Fe + succinate + hydroxyl lysine <br /> |
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| *Salicilate hydroxylase | | *Salicylate hydroxylase |
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| **[[5evy]] - PpSH + FAD + salicilate <br /> | | **[[5evy]] - PpSH + FAD + salicilate <br /> |
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| **[[4mhu]] - SaEH + Fe <br /> | | **[[4mhu]] - SaEH + Fe <br /> |
| **[[4q5o]] - SaEH + Fe + 5-hydroxyectoine<br /> | | **[[4q5o]] - SaEH + Fe + 5-hydroxyectoine<br /> |
| | **[[4nmi]] - VsEH – ''Virgibacillus salexigens''<br /> |
| | **[[3emr]] - VsEH + Fe <br /> |
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| *Hyoscyamine 6 b-hydroxylase | | *Hyoscyamine 6 b-hydroxylase |
3D structures of hydroxylases3D structures of hydroxylases
Updated on 29-September-2021
{"openlevels":0}
- Phenylalanine hydroxylase
- 6n1k – hPAH (mutant) – human
- 6hyc – hPAH + cofactor
- 1j8t, 1pah, 2pah - hPAH catalytic domain
- 1tdw – hPAH catalytic domain (mutant)
- 6hpo – hPAH catalytic domain + Fe
- 3pah, 4pah – hPAH catalytic domain + adrenaline inhibitor
- 5pah, 6pah - hPAH catalytic domain + dopamine inhibitor
- 1j8u - hPAH catalytic domain + cofactor
- 1dmw - hPAH catalytic domain + cofactor
- 1tg2, 1lrm - hPAH catalytic domain (mutant) + cofactor
- 1mmk, 1mmt, 1kw0 - hPAH catalytic domain + cofactor + substrate
- 4anp - hPAH catalytic domain + pyrimidine derivative
- 5fii, 5fgi - hPAH residues 19-118 + phenylalanine
- 1phz, 2phm, 5den, 5fgj, 5den – rPAH - rat
- 5egq - rPAH (mutant)
- 5jk6 - smPAH + Fe – slime mold
- 5jk5 - smPAH + cofactor + Fe
- 5jk8 - smPAH + cofactor + Fe + norleucine
- 2v27, 2v28 – PAH – Colwellia psychrerythraea
- 1ltu, 1ltv – CvPAH – Chromobacterium violaceum
- 1phz, 2phm, 5fgj, 5den – rPAH - rat
- 5egq - rPAH (mutant)
- 4bpt – PAH – Legionella pneumophila
- 1ltz - CvPAH + cofactor
- 3tcy, 3tk2 – CvPAH + phenylalanine
- 3tk4 – CvPAH + Co
- 4esm, 4etl, 4q3w, 4q3x, 4q3y, 4q3z - CvPAH (mutant) + Co
- 4jpx - CvPAH (mutant) + Co + phenylalanine
- 4jpy - CvPAH + Fe + phenylalanine
- Tyrosine hydroxylase
- 2xsn – hTH catalytic domain
- [2toh]], 1toh – TH catalytic and tetramerization domains - rat
- 7kqr, 7kqs, 7kqt, 7kqu – TH + heme + Tyr derivative – Streptomyces sclerotialus
- Tryptophan hydroxylase
- 3hf8, 3hfb, 3hf6, 5tpg, 5l01, 5j6d – hTPH 1 catalytic domain+ inhibitor + Fe
- 1mlw – hTPH catalytic domain+ biopterin + Fe
- 4v06 - hTPH 2 catalytic domain + Fe
- 3e2t – TPH 1 catalytic domain + Trp + Fe – chicken
- p-hydroxybenzoate hydroxylase
- 1phh – PfPHBH + FAD + DHB – Pseudomonas fluorescens
- 1dob, 1doc, 1pxa, 1pxb, 1pxc – PaPHBH + FAD + PHB – Pseudomonas aeruginosa
- 2phh – PfPHBH + adenosine diphosphoribose + PHB
- 1pbb – PfPHBH + FAD + 2,4-DHB
- 1pbc, 1pbf – PfPHBH + FAD + 2-hydroxy-4-aminobenzoate
- 1pbd – PfPHBH + FAD + 4-aminobenzoate
- 1pbe – PfPHBH + FAD + PHB
- 1bkw, 1bf3, 1bgj, 1bgn, 1cc4, 1cc6 – PfPHBH (mutant) + FAD + PHB
- 1pdh – PfPHBH + FAD derivative + PHB
- 1cj2, 1cj3, 1cj4 – PfPHBH (mutant) + FAD derivative + PHB
- 1dob, 1doc, 1pxa, 1pxb, 1pxc – PaPHBH + FAD + PHB – Pseudomonas aeruginosa
- 1dod, 1doe, 1iuv, 1iuw, 1iux – PaPHBH + FAD + DHB derivative
- 1ius, 1iut, 1iuu – PaPHBH + FAD + 4-aminobenzoate
- 6ju1 – PaPHBH (mutant) + FAD + DHB derivative
- 1d7l – PaPHBH + FAD derivative + PHB
- 1k0i, 1ykj – PaPHBH (mutant) + FAD + PHB
- 1k0j – PaPHBH (mutant) + FAD + NADPH
- 1k0l – PaPHBH (mutant) + FAD
- 5tti, 6dll – PfPHBH + FAD – Pseudomonas putida
- 2dki – CtPHBH + FAD – Comamonas testosteroni
- 2dkh – CtPHBH + FAD + hydroxy-benzoate
- Apartyl/asparaginyl β-hydroxylase; Domain – oxygenase and TPR 301-758
- 6qa5 – hAAH oxygenase and TPR domain
- 5jz6 – hAAH oxygenase and TPR domain + malate + Mn
- 5apa – hAAH residues 562-758 + malate + Ni
- 5jza – hAAH oxygenase and TPR domain + oxalylglycine + Mn
- 6yyu, 6yyv – hAAH oxygenase and TPR domain + oxoglutarate + Mn
- 6yyw, 6yyx, 6yyy, 6z6q – hAAH oxygenase and TPR domain + oxoglutarate + Mn + coagulation factor X peptide
- 5jz8, 5jzu, 6rk9, 5jqy, 6rk9, 6z6r – hAAH oxygenase and TPR domain + oxalyl derivative + Mn + coagulation factor X peptide
- 7e6j – hAAH oxygenase and TPR domain (mutant) + coagulation factor X peptide
- 6q9f, 6q9i – hAAH oxygenase and TPR domain (mutant) + oxalylglycine + Mn + coagulation factor X peptide
- 5jtc, 7bmi, 7bmj – hAAH oxygenase and TPR domain + pyridine dicarboxylate + Mn + coagulation factor X peptide
- Alpha-ketoglutarate-dependent L-arginine hydroxylase
- 6dax, 6alm, 6aln, 6mp8 – SvAAH + arginine + oxoglutarate + Fe – Streptomyces vinaceus
- 6daz, 6alo, 6alp, 6alq, 6y12 – SvAAH + arginine + succinate + Fe
- 6y0n – SvAAH + arginine + AKG + Fe
- 6db2, 6alr – SvAAH + homoarginine + succinate + V
- 6mp9 – SvAAH + guanidinopentanoate + succinate + Fe
- PLP-dependent L-arginine hydroxylase
- 6c9b – SwAAH + PLP – Streptomyces wadayamensis
- 5dj1 – SwAAH + PLP + Mg
- 5dj3 – SwAAH + PLP-arginine + Mg
- 5bk7 – SwAAH (mutant) + PLP-arginine
- 6c8t, 6c92 – SwAAH + PLP-arginine + PLP derivative
- Leucine hydroxylase
- 5nch – StAAH – Streptomyces
- 5nci – StAAH + leucine derivative + oxoglutarate + Co
- 5ncj – StAAH + leucine derivative + succinate + Mn
- L-arginine b-hydroxylase or non-heme iron oxygenase
- 4m23 – SlORFP – Streptomyces lavendulae
- 4m2i – SlORFP + Fe
- 4m25 – SlORFP + Fe + ketoglutarate
- 4m27, 4m2c – SlORFP + Fe + Arg
- 4m2e – SlORFP + Fe + Arg derivative
- 4m2f – SlORFP + Fe + canavanine
- 4m2g, 4m26 – SlORFP + Fe + succinate + Arg derivative
- 2wbo – SvVIOC + Fe + Arg – Streptomyces vinaceus
- 2wbq – SvVIOC + Arg derivative
- 2wbp – SvVIOC + Fe + succinate + Arg derivative
- 6daw – NAPI + Fe + Arg – Streptomyces lusitanus
- Prolyl 4-hydroxylase
- 4bt8, 2yq8 - hPH a1 subunit collagen-binding domain
- 1tjc - hPH a1 subunit collagen-binding domain (mutant)
- 4btb, 4bta, 4bt9 - hPH a1 subunit + peptide
- 6evl - hPH a2 subunit
- 6evm, 6evn, 6evo, 6evp - hPH a2 subunit + peptide
- 5hv0 - PH + Cd – Bacillus anthracis
- 5c5u - PcvPH + Mn – Paramecium chlorella virus
- 5c5t - PcvPH + Mn + Zn
- 4p7x - RlPH + Co + pipecolic acid – Rhizobium loti
- 4p7w - RlPH + Co + proline
- 6iuq - PH + Fe – Phytophthora capsici
- 2v4a, 2jij - CrPH – Chlamydomonas reinhardtii
- 2jig - CrPH + Zn + pyridine derivative
- HIF prolyl hydroxylase or egl nine homolog See Prolyl hydroxylase domain
- Lysine 4-hydroxylase
- 6f9p – FlL4H + Fe – Flavobacterium
- 6exf – FlL4H + Fe + lysine
- 6euo – FlL4H + Fe + succinate derivative
- 6eur – FlL4H + Fe + oxoglutarate
- 6exh – FlL4H + Fe + lysine + succinate
- Lysine 3-hydroxylase
- 6f2e – CaL3H – Catenulispora acidiphila
- 6f2b – CaL3H + Fe + oxoglutarate
- 6f2a – CaL3H + Fe + lysine
- 6f6j – CaL3H + Fe + succinate + hydroxyl lysine
- Salicylate hydroxylase
- 5evy - PpSH + FAD + salicilate
- Dopamine β-hydroxylase
- Ectoine hydroxylase
- 4mhr - SaEH – Sphingopyxis alaskensis
- 4mhu - SaEH + Fe
- 4q5o - SaEH + Fe + 5-hydroxyectoine
- 4nmi - VsEH – Virgibacillus salexigens
- 3emr - VsEH + Fe
- Hyoscyamine 6 b-hydroxylase
- 6ttm, 6ttn - dHH + Ni + oxalylglycine + hyoscyamine – datura
- 6tto - dHH + Ni + oxoglutaratee
- Cytochrome P450 hydroxylase See Cytochrome P450 hydroxylase