4mhr

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Crystal structure of EctD from S. alaskensis in its apoformCrystal structure of EctD from S. alaskensis in its apoform

Structural highlights

4mhr is a 1 chain structure with sequence from Sphingopyxis alaskensis RB2256. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.1Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ECTD_SPHAL Involved in the biosynthesis of 5-hydroxyectoine, called compatible solute, which helps organisms to survive extreme osmotic stress by acting as a highly soluble organic osmolyte. Catalyzes the 2-oxoglutarate-dependent selective hydroxylation of L-ectoine to yield (4S,5S)-5-hydroxyectoine.[1] [2]

See Also

References

  1. ↑ Widderich N, Hoppner A, Pittelkow M, Heider J, Smits SH, Bremer E. Biochemical properties of ectoine hydroxylases from extremophiles and their wider taxonomic distribution among microorganisms. PLoS One. 2014 Apr 8;9(4):e93809. doi: 10.1371/journal.pone.0093809. eCollection , 2014. PMID:24714029 doi:http://dx.doi.org/10.1371/journal.pone.0093809
  2. ↑ Hoeppner A, Widderich N, Lenders M, Bremer E, Smits SH. Crystal Structure of the Ectoine Hydroxylase: a Snapshot of the Active Site. J Biol Chem. 2014 Aug 29. pii: jbc.M114.576769. PMID:25172507 doi:http://dx.doi.org/10.1074/jbc.M114.576769

4mhr, resolution 2.10Å

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OCA
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