Crystal Structure of the Apo ectoine hydroxylase ECTD from Salibacillus salexigensCrystal Structure of the Apo ectoine hydroxylase ECTD from Salibacillus salexigens

Structural highlights

4nmi is a 1 chain structure with sequence from Virgibacillus salexigens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.78Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ECTD_VIRSA Involved in the biosynthesis of ectoine ((S)-2-methyl-1,4,5,6-tetrahydropyrimidine-4-carboxylic acid) which is a highly soluble organic osmolyte, called compatible solute, use to avoid excessive water efflux, plasmolysis, molecular crowding of the cytoplasm, and cessation of growth in high salinity environments. Catalyzes the 2-oxoglutarate-dependent selective hydroxylation of L-ectoine to yield (4S,5S)-5-hydroxyectoine.[1]

See Also

References

  1. Bursy J, Pierik AJ, Pica N, Bremer E. Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase. J Biol Chem. 2007 Oct 26;282(43):31147-55. Epub 2007 Jul 18. PMID:17636255 doi:http://dx.doi.org/10.1074/jbc.M704023200

4nmi, resolution 1.78Å

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