Sodium-hydrogen exchange regulatory factor: Difference between revisions
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== Function == | == Function == | ||
'''Sodium-hydrogen exchange regulatory factors''' (NHERF) or '''ezrin-radixin-moesin binding phosphoprotein-50''' or '''PDZ domain-containing protein''' are multifunctional adaptor protein which plays a role in the assembly of signal transduction complexes, linking ion channels and receptors to the actin skeleton<ref>PMID:11141479</ref>. NHERF-1 is the major isoform present in the brain and it regulates the trans-cellular ion transport through the blood-brain barrier membrane<ref>PMID:26010555</ref>. | '''Sodium-hydrogen exchange regulatory factors''' (NHERF) or '''ezrin-radixin-moesin binding phosphoprotein-50''' or '''PDZ domain-containing protein''' or '''Na+/H+ exchange regulatory cofactor NHE-RF1''' or '''NHERF''' are multifunctional adaptor protein which plays a role in the assembly of signal transduction complexes, linking ion channels and receptors to the actin skeleton<ref>PMID:11141479</ref>. NHERF-1 is the major isoform present in the brain and it regulates the trans-cellular ion transport through the blood-brain barrier membrane<ref>PMID:26010555</ref>. | ||
== Relevance == | == Relevance == | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
*Sodium-hydrogen exchange regulatory factor 1 | *Sodium-hydrogen exchange regulatory factor 1; Domains – PDZ 1 11-120; PDZ 2 150-235; PDZ 3 246-335; PDZ 4 375-459 | ||
**[[1g9o]], [[1gq5]], [[1gq4]] – hNHERF-1 PDZ 1 domain – human <br /> | **[[1g9o]], [[1gq5]], [[1gq4]] – hNHERF-1 PDZ 1 domain – human <br /> | ||
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**[[4q2p]] – hNHERF-3 PDZ 2 domain/phage peptide <br /> | **[[4q2p]] – hNHERF-3 PDZ 2 domain/phage peptide <br /> | ||
**[[2eei]] – mNHERF-3 PDZ 2 domain - NMR<br /> | **[[2eei]] – mNHERF-3 PDZ 2 domain - NMR<br /> | ||
**[[2v90]] – hNHERF-3 PDZ 3 domain <br /> | **[[2v90]] – hNHERF-3 PDZ 3 domain <br /> | ||
**[[3r69]] – mNHERF-3 PDZ 3 domain/HDL receptor<br /> | **[[3r69]] – mNHERF-3 PDZ 3 domain/HDL receptor<br /> | ||
**[[3tmh]] – hNHERF-3 PDZ 3 domain + CAMP-dependent protein kinase docking domain + AKAP-10 A-kinase-binding domain<br /> | **[[3tmh]] – hNHERF-3 PDZ 3 domain + CAMP-dependent protein kinase docking domain + AKAP-10 A-kinase-binding domain<br /> | ||
**[[3r68]] – mNHERF-3 PDZ 3 domain<br /> | |||
**[[2d90]] – mNHERF-3 PDZ 3 domain - NMR<br /> | |||
**[[2vsp]] – hNHERF-3 PDZ 4 domain <br /> | **[[2vsp]] – hNHERF-3 PDZ 4 domain <br /> | ||
**[[6ezi]] – hNHERF-3 PDZ 4 domain + peptide transporter peptide<br /> | **[[6ezi]] – hNHERF-3 PDZ 4 domain + peptide transporter peptide<br /> | ||
**[[4r2z]] – mNHERF-3 PDZ 4 domain <br /> | **[[4r2z]] – mNHERF-3 PDZ 4 domain <br /> | ||
**[[2edz]] – mNHERF-3 PDZ 4 domain - NMR<br /> | |||
}} | }} | ||
== References == | == References == | ||
Revision as of 11:30, 5 November 2020
FunctionSodium-hydrogen exchange regulatory factors (NHERF) or ezrin-radixin-moesin binding phosphoprotein-50 or PDZ domain-containing protein or Na+/H+ exchange regulatory cofactor NHE-RF1 or NHERF are multifunctional adaptor protein which plays a role in the assembly of signal transduction complexes, linking ion channels and receptors to the actin skeleton[1]. NHERF-1 is the major isoform present in the brain and it regulates the trans-cellular ion transport through the blood-brain barrier membrane[2]. RelevanceNHERF-1 inhibitors represent a potentially effective therapeutic approach to the treatment of hear failure[3]. NHERF-1 has a vital role in kidney cell survival[4]. NHERF are known to be involved in pathophysiologies of many brain diseases like epilepsy, Alzhheimer's disease, neuropathic pain and stroke. Structural highlightsNHERF interacts with ion transporters and receptors via its PDZ domains and with the merlin, ezrin, radixin and moesin proteins via its c-terminal. The CXCR2 peptide binds the second PDZ domain hydrophobic cleft[5].
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3D Structures of sodium-hydrogen exchange regulatory factor3D Structures of sodium-hydrogen exchange regulatory factor
Updated on 05-November-2020
ReferencesReferences
- ↑ Stemmer-Rachamimov AO, Wiederhold T, Nielsen GP, James M, Pinney-Michalowski D, Roy JE, Cohen WA, Ramesh V, Louis DN. NHE-RF, a merlin-interacting protein, is primarily expressed in luminal epithelia, proliferative endometrium, and estrogen receptor-positive breast carcinomas. Am J Pathol. 2001 Jan;158(1):57-62. doi: 10.1016/S0002-9440(10)63944-2. PMID:11141479 doi:http://dx.doi.org/10.1016/S0002-9440(10)63944-2
- ↑ Song S, Sun X, Li X, Yuan Y, Jiao N. Efficient and Practical Oxidative Bromination and Iodination of Arenes and Heteroarenes with DMSO and Hydrogen Halide: A Mild Protocol for Late-Stage Functionalization. Org Lett. 2015 Jun 19;17(12):2886-9. doi: 10.1021/acs.orglett.5b00932. Epub 2015 , May 26. PMID:26010555 doi:http://dx.doi.org/10.1021/acs.orglett.5b00932
- ↑ Morris K. Targeting the myocardial sodium-hydrogen exchange for treatment of heart failure. Expert Opin Ther Targets. 2002 Jun;6(3):291-8. doi: 10.1517/14728222.6.3.291 . PMID:12223070 doi:http://dx.doi.org/10.1517/14728222.6.3.291
- ↑ Parker MD, Myers EJ, Schelling JR. Na+-H+ exchanger-1 (NHE1) regulation in kidney proximal tubule. Cell Mol Life Sci. 2015 Jun;72(11):2061-74. doi: 10.1007/s00018-015-1848-8. Epub , 2015 Feb 14. PMID:25680790 doi:http://dx.doi.org/10.1007/s00018-015-1848-8
- ↑ Song S, Sun X, Li X, Yuan Y, Jiao N. Efficient and Practical Oxidative Bromination and Iodination of Arenes and Heteroarenes with DMSO and Hydrogen Halide: A Mild Protocol for Late-Stage Functionalization. Org Lett. 2015 Jun 19;17(12):2886-9. doi: 10.1021/acs.orglett.5b00932. Epub 2015 , May 26. PMID:26010555 doi:http://dx.doi.org/10.1021/acs.orglett.5b00932