Cell death protein: Difference between revisions

From Proteopedia
Jump to navigation Jump to search
← Older editNewer edit →
Michal Harel (talk | contribs)
31,761 edits
No edit summary
Michal Harel (talk | contribs)
31,761 edits
No edit summary
Line 10: Line 10:
*CED-1
*CED-1


**[[1npu]] – mCED-1 extracellular domain (mutant) - mouse<br />
**[[3rrq]] - hCED-1 extracellular domain (mutant) - human<br />
**[[3rrq]] - hCED-1 extracellular domain (mutant) - human<br />
**[[2m2d]] - hCED-1 extracellular domain - NMR<br />
**[[2m2d]] - hCED-1 extracellular domain - NMR<br />
Line 16: Line 15:
**[[5wt9]], [[5jxe]], [[5b8c]] - hCED-1 extracellular domain + antibody<br />
**[[5wt9]], [[5jxe]], [[5b8c]] - hCED-1 extracellular domain + antibody<br />
**[[5ggs]], [[5ggr]] - hCED-1 extracellular domain (mutant) + antibody<br />
**[[5ggs]], [[5ggr]] - hCED-1 extracellular domain (mutant) + antibody<br />
**[[1npu]] – mCED-1 extracellular domain (mutant) - mouse<br />
**[[3bik]] - mCED-1 extracellular domain (mutant) + hCED-L1 extracellular domain<br />
**[[3bik]] - mCED-1 extracellular domain (mutant) + hCED-L1 extracellular domain<br />
**[[3sbw]] - mCED-1 extracellular domain + hCED-L1 extracellular domain<br />
**[[3sbw]] - mCED-1 extracellular domain + hCED-L1 extracellular domain<br />
Line 32: Line 32:
*CED-4
*CED-4


**[[2a5y]] - CeCED-4 + CeCED-9 <BR />
**[[3lqq]], [[3lqr]] - CeCED-4<BR />
**[[2ggf]] – hCED-4 MA3 domain – NMR<BR />
**[[2ggf]] – hCED-4 MA3 domain – NMR<BR />
**[[2rg8]], [[2kzt]] - hCED-4 MA3 domain<BR />
**[[2rg8]], [[2kzt]] - hCED-4 MA3 domain<BR />
**[[3eij]] - hCED-4 residues 157-469<BR />
**[[2zu6]], [[3eiq]] - hCED-4 residues 163-469 + eukaryotic initiation factor 4A-I<br />
**[[2iol]], [[2ion]], [[2ios]], [[2nsz]] - mCED-4 MA3 domain<BR />
**[[2iol]], [[2ion]], [[2ios]], [[2nsz]] - mCED-4 MA3 domain<BR />
**[[2hm8]] - mCED-4 MA3 domain – NMR<BR />
**[[2hm8]] - mCED-4 MA3 domain – NMR<BR />
**[[3eij]] - hCED-4 residues 157-469<BR />
**[[2zu6]], [[3eiq]] - hCED-4 residues 163-469 + eukaryotic initiation factor 4A-I<br />
**[[4m9s]], [[4m9x]], [[4m9y]], [[4m9z]] - nCED-4 + nCED-3 fragment<br />
**[[4m9s]], [[4m9x]], [[4m9y]], [[4m9z]] - nCED-4 + nCED-3 fragment<br />
**[[2a5y]] - CeCED-4 + CeCED-9 <BR />
**[[3lqq]], [[3lqr]] - CeCED-4<BR />


*CED-5
*CED-5
Line 49: Line 49:
*CED-6
*CED-6


**[[1y1x]] - CED-6 – ''Leishmania major''<br />
**[[1hqv]] - mCED-6<br />
**[[2zn8]], [[2zn9]], [[2znd]], [[2zrs]], [[2zrt]] - hCED-6<br />
**[[2zn8]], [[2zn9]], [[2znd]], [[2zrs]], [[2zrt]] - hCED-6<br />
**[[3aaj]], [[3aak]] - hCED-6 (mutant)<br />
**[[3aaj]], [[3aak]] - hCED-6 (mutant)<br />
Line 56: Line 54:
**[[3wxa]] - hCED-6 + SEC31A peptide<br />
**[[3wxa]] - hCED-6 + SEC31A peptide<br />
**[[5gqq]] - hCED-6 + heme-binding protein<br />
**[[5gqq]] - hCED-6 + heme-binding protein<br />
**[[1hqv]] - mCED-6<br />
**[[1y1x]] - CED-6 – ''Leishmania major''<br />


*CED-8 (apoptosis-inducing factor 1)
*CED-8 (apoptosis-inducing factor 1)


**[[1m6i]], [[4bv6]], [[4lii]] - hCED-8<br />
**[[5fmh]], [[5kvh]], [[5kvi]], [[5fs6]], [[5fs7]], [[5fs8]], [[4fdc]] – hCED-8 (mutant)  <br />
**[[5fs9]] – hCED-8 (mutant)  + FAD<br />
**[[4bur]] – hCED-8 + NAD <br />
**[[1gv4]], [[3gd3]] - mCED-8<br />
**[[1gv4]], [[3gd3]] - mCED-8<br />
**[[3gd4]] – mCED-8 + NAD <br />
**[[3gd4]] – mCED-8 + NAD <br />
**[[5miu]] – mCED-8 (mutant) + FAD <br />
**[[5miu]] – mCED-8 (mutant) + FAD <br />
**[[5miv]] – mCED-8 (mutant) + FAD + NAD<br />
**[[5miv]] – mCED-8 (mutant) + FAD + NAD<br />
**[[1m6i]], [[4bv6]], [[4lii]] - hCED-8<br />
**[[5fmh]], [[5kvh]], [[5kvi]], [[5fs6]], [[5fs7]], [[5fs8]], [[4fdc]] – hCED-8 (mutant)  <br />
**[[5fs9]] – hCED-8 (mutant)  + FAD<br />
**[[4bur]] – hCED-8 + NAD <br />


*CED-9
*CED-9

Revision as of 09:52, 2 July 2020


Cell death proteins or Programmed cell death protein or CD279 (CED) are involved in the process of cellular apoptosis. CED-1 is a T cell regulator. CED-1 is expressed on the surface of T cells, B cells and macrophages. It is a membrane protein and acts in suppressing the immune system during pregnancy, tissue allografts, autoimmune diseases and hepatitis. CED-1 has 2 ligands: CED-L1 and CED-L2. Formation of CED-1/CED-L1 complex reduces T cell proliferation at the lymph nodes. [1] For details on CED-4 see CED-4 Apoptosome. (3bik).[2]. For details on CED-8 see Apoptosis-inducing factor.

Human CED-1 extracellular domain. Programmed cell death protein 1 (green and magenta) and programmed cell death 1 ligand 1 (cyan) complex with glycerol (PDB code 3bik)

Drag the structure with the mouse to rotate

3D structures of cell death protein3D structures of cell death protein

Updated on 02-July-2020

ReferencesReferences

  1. ↑ Zak KM, Kitel R, Przetocka S, Golik P, Guzik K, Musielak B, Domling A, Dubin G, Holak TA. Structure of the Complex of Human Programmed Death 1, PD-1, and Its Ligand PD-L1. Structure. 2015 Oct 22. pii: S0969-2126(15)00402-5. doi:, 10.1016/j.str.2015.09.010. PMID:26602187 doi:http://dx.doi.org/10.1016/j.str.2015.09.010
  2. ↑ Lin DY, Tanaka Y, Iwasaki M, Gittis AG, Su HP, Mikami B, Okazaki T, Honjo T, Minato N, Garboczi DN. The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors. Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):3011-6. Epub 2008 Feb 14. PMID:18287011

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=Cell_death_protein&oldid=3254034"