Sodium-hydrogen exchange regulatory factor: Difference between revisions

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**[[3ngh]] – mNHERF-3 PDZ 1 domain/HDL receptor - mouse<br />
**[[3ngh]] – mNHERF-3 PDZ 1 domain/HDL receptor - mouse<br />
**[[4f8k]] – mNHERF-3 PDZ 1 domain (mutant)/prostacyclin receptor<br />
**[[4f8k]] – mNHERF-3 PDZ 1 domain (mutant)/prostacyclin receptor<br />
**[[2edz]] – mNHERF-3 PDZ 1 domain - NMR<br />
**[[4q2p]] – hNHERF-3 PDZ 2 domain/phage peptide <br />
**[[4q2p]] – hNHERF-3 PDZ 2 domain/phage peptide <br />
**[[2eei]] – mNHERF-3 PDZ 2 domain - NMR<br />
**[[3r68]] – mNHERF-3 PDZ 3 domain<br />
**[[3r68]] – mNHERF-3 PDZ 3 domain<br />
**[[2d90]] – mNHERF-3 PDZ 3 domain - NMR<br />
**[[2v90]] – hNHERF-3 PDZ 3 domain <br />
**[[3r69]] – mNHERF-3 PDZ 3 domain/HDL receptor<br />
**[[3r69]] – mNHERF-3 PDZ 3 domain/HDL receptor<br />
**[[3tmh]] – hNHERF-3 PDZ 3 domain + CAMP-dependent protein kinase docking domain + AKAP-10 A-kinase-binding domain<br />
**[[3tmh]] – hNHERF-3 PDZ 3 domain + CAMP-dependent protein kinase docking domain + AKAP-10 A-kinase-binding domain<br />
**[[2vsp]] – hNHERF-3 PDZ 4 domain <br />
**[[2edz]] – mNHERF-3 PDZ 4 domain - NMR<br />
**[[6ezi]] – hNHERF-3 PDZ 4 domain + peptide transporter peptide<br />
**[[4r2z]] – mNHERF-3 PDZ 4 domain <br />
**[[4r2z]] – mNHERF-3 PDZ 4 domain <br />
}}
}}

Revision as of 11:48, 9 February 2020


Function

Sodium-hydrogen exchange regulatory factors (NHERF) or ezrin-radixin-moesin binding phosphoprotein-50 or PDZ domain-containing protein are multifunctional adaptor protein which plays a role in the assembly of signal transduction complexes, linking ion channels and receptors to the actin skeleton[1]. NHERF-1 is the major isoform present in the brain and it regulates the trans-cellular ion transport through the blood-brain barrier membrane[2].

Relevance

NHERF-1 inhibitors represent a potentially effective therapeutic approach to the treatment of hear failure[3]. NHERF-1 has a vital role in kidney cell survival[4]. NHERF are known to be involved in pathophysiologies of many brain diseases like epilepsy, Alzhheimer's disease, neuropathic pain and stroke.

Structural highlights

NHERF interacts with ion transporters and receptors via its PDZ domains and with the merlin, ezrin, radixin and moesin proteins via its c-terminal. The CXCR2 peptide binds the second PDZ domain hydrophobic cleft[5].


Human NHERF-1 second PDZ domain with CXCR2 peptide chimera (PDB cod 4q3h)

Drag the structure with the mouse to rotate

3D Structures of sodium-hydrogen exchange regulatory factor3D Structures of sodium-hydrogen exchange regulatory factor

Updated on 09-February-2020

ReferencesReferences

  1. ↑ Stemmer-Rachamimov AO, Wiederhold T, Nielsen GP, James M, Pinney-Michalowski D, Roy JE, Cohen WA, Ramesh V, Louis DN. NHE-RF, a merlin-interacting protein, is primarily expressed in luminal epithelia, proliferative endometrium, and estrogen receptor-positive breast carcinomas. Am J Pathol. 2001 Jan;158(1):57-62. doi: 10.1016/S0002-9440(10)63944-2. PMID:11141479 doi:http://dx.doi.org/10.1016/S0002-9440(10)63944-2
  2. ↑ Song S, Sun X, Li X, Yuan Y, Jiao N. Efficient and Practical Oxidative Bromination and Iodination of Arenes and Heteroarenes with DMSO and Hydrogen Halide: A Mild Protocol for Late-Stage Functionalization. Org Lett. 2015 Jun 19;17(12):2886-9. doi: 10.1021/acs.orglett.5b00932. Epub 2015 , May 26. PMID:26010555 doi:http://dx.doi.org/10.1021/acs.orglett.5b00932
  3. ↑ Morris K. Targeting the myocardial sodium-hydrogen exchange for treatment of heart failure. Expert Opin Ther Targets. 2002 Jun;6(3):291-8. doi: 10.1517/14728222.6.3.291 . PMID:12223070 doi:http://dx.doi.org/10.1517/14728222.6.3.291
  4. ↑ Parker MD, Myers EJ, Schelling JR. Na+-H+ exchanger-1 (NHE1) regulation in kidney proximal tubule. Cell Mol Life Sci. 2015 Jun;72(11):2061-74. doi: 10.1007/s00018-015-1848-8. Epub , 2015 Feb 14. PMID:25680790 doi:http://dx.doi.org/10.1007/s00018-015-1848-8
  5. ↑ Song S, Sun X, Li X, Yuan Y, Jiao N. Efficient and Practical Oxidative Bromination and Iodination of Arenes and Heteroarenes with DMSO and Hydrogen Halide: A Mild Protocol for Late-Stage Functionalization. Org Lett. 2015 Jun 19;17(12):2886-9. doi: 10.1021/acs.orglett.5b00932. Epub 2015 , May 26. PMID:26010555 doi:http://dx.doi.org/10.1021/acs.orglett.5b00932

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman
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