Fatty acid-binding protein: Difference between revisions
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The <scene name='48/487562/Cv/5'>FABP active site binds fatty acids</scene> ({{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}})<ref>PMID:10854433</ref>. | The <scene name='48/487562/Cv/5'>FABP active site binds fatty acids</scene> ({{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}})<ref>PMID:10854433</ref>. | ||
==3D structures of fatty acid-binding protein== | |||
[[Fatty acid-binding protein 3D structures]] | |||
</StructureSection> | </StructureSection> | ||
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*Intestinal fatty acid-binding protein | *Intestinal fatty acid-binding protein | ||
**[[1kzw]], [[3ifb]] - hIFABP – human – NMR<BR /> | |||
**[[1kzx]] - hIFABP (mutant) – NMR<BR /> | |||
**[[1ael]], [[1a57]], [[1sa8]] - rIFABP – rat – NMR<BR /> | **[[1ael]], [[1a57]], [[1sa8]] - rIFABP – rat – NMR<BR /> | ||
**[[1t8v]] - rIFABP (mutant) – NMR<BR /> | **[[1t8v]] - rIFABP (mutant) – NMR<BR /> | ||
**[[1ifb]], [[1ifc]] - rIFABP <br /> | **[[1ifb]], [[1ifc]] - rIFABP <br /> | ||
**[[1dc9]] - rIFABP (mutant)<br /> | **[[1dc9]] - rIFABP (mutant)<br /> | ||
*''Intestinal fatty acid-binding protein binary complex'' | *''Intestinal fatty acid-binding protein binary complex'' | ||
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**[[1b56]], [[1jjj]], [[4lkp]] - hEFABP <br /> | **[[1b56]], [[1jjj]], [[4lkp]] - hEFABP <br /> | ||
**[[4azr]], [[4lkt]] - hEFABP + fatty acid<br /> | **[[4azr]], [[4lkt]] - hEFABP + fatty acid<br /> | ||
**[[4azm]], [[5ur9]], [[5hz5]] - hEFABP + inhibitor<br /> | |||
**[[4azn]], [[4azo]] - mEFABP <br /> | **[[4azn]], [[4azo]] - mEFABP <br /> | ||
**[[4azp]], [[4azq]] - mEFABP + fatty acid<br /> | **[[4azp]], [[4azq]] - mEFABP + fatty acid<br /> | ||
*Heart-type fatty acid-binding protein | *Heart-type fatty acid-binding protein | ||
**[[1g5w]] - hHFABP – NMR<BR /> | **[[1g5w]] - hHFABP – NMR<BR /> | ||
**[[3rsw]], [[5ce4]] – hHFABP<br /> | **[[3rsw]], [[5ce4]], [[6aq1]] – hHFABP<br /> | ||
**[[3wbg]] – hHFABP + sulfonate derivative<br /> | **[[3wbg]] – hHFABP + sulfonate derivative<br /> | ||
**[[5hz9]] – hHFABP + inhibitor<br /> | **[[5hz9]] – hHFABP + inhibitor<br /> | ||
**[[3wvm]], [[4tjz]], [[4tkb]], [[4tkh]], [[4tkj]], [[4wbk]], [[3wxq]] - hHFABP + fatty acid<br /> | **[[3wvm]], [[4tjz]], [[4tkb]], [[4tkh]], [[4tkj]], [[4wbk]], [[3wxq]] - hHFABP + fatty acid<br /> | ||
**[[5b29]], [[5b28]], [[5b27]] - hHFABP (mutant) + fatty acid<br /> | |||
**[[1bwy]] – HFABP – bovine<br /> | **[[1bwy]] – HFABP – bovine<br /> | ||
**[[5d8j]] – HFABP + Fab – mouse<br /> | **[[5d8j]] – HFABP + Fab – mouse<br /> | ||
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**[[1fdq]], [[1jjx]] - hBFABP<br /> | **[[1fdq]], [[1jjx]] - hBFABP<br /> | ||
**[[1fe3]] - hBFABP + oleate<br /> | **[[1fe3]] - hBFABP + oleate<br /> | ||
**[[5ura]] - hBFABP + inhibitor <br /> | |||
*Liver-type fatty acid-binding protein | *Liver-type fatty acid-binding protein | ||
**[[ | **[[2f73]], [[3stn]], [[3b2h]], [[3b2i]], [[3b2j]], [[3b2k]], [[3b2l]], [[3vg2]], [[3vg3]], [[3vg4]], [[3vg5]], [[3vg6]], [[3vg7]] - hLFABP<br /> | ||
**[[2py1]], [[2l67]], [[2l68]] - hLFABP – NMR<BR /> | |||
**[[1tvq]], [[1mvg]] - cLFABP – chicken<br /> | **[[1tvq]], [[1mvg]] - cLFABP – chicken<br /> | ||
**[[1zry]] - cLFABP - NMR<BR /> | **[[1zry]] - cLFABP - NMR<BR /> | ||
**[[2ju3]], [[2ju7]] - rLFABP – NMR<BR /> | **[[2ju3]], [[2ju7]] - rLFABP – NMR<BR /> | ||
**[[1p6p]] - LFABP – toad<br /> | |||
**[[2ft9]] – AmLFABP - ''Ambystoma mexicanum'' | **[[2ft9]] – AmLFABP - ''Ambystoma mexicanum'' | ||
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**[[1tou]], [[2hnx]], [[3q6l]], [[3rzy]] - hAFABP<br /> | **[[1tou]], [[2hnx]], [[3q6l]], [[3rzy]] - hAFABP<br /> | ||
**[[1tow]] - hAFABP + carbazole butanoic acid<br /> | **[[1tow]] - hAFABP + carbazole butanoic acid<br /> | ||
**[[2nnq]], [[3fr2]], [[3fr4]], [[3fr5]], [[5hz6]], [[5hz8]], [[5d45]], [[5d47]], [[5d48]], [[5d4a]], [[5edb]], [[5edc]], [[4nns]], [[4nnt]] - hAFABP + inhibitor<br /> | **[[2nnq]], [[3fr2]], [[3fr4]], [[3fr5]], [[5hz6]], [[5hz8]], [[5d45]], [[5d47]], [[5d48]], [[5d4a]], [[5edb]], [[5edc]], [[4nns]], [[4nnt]], [[5y0f]], [[5y0g]], [[5y0x]], [[5y12]], [[5y13]] - hAFABP + inhibitor<br /> | ||
**[[3p6c]] - hAFABP + citrate<br /> | **[[3p6c]] - hAFABP + citrate<br /> | ||
**[[3p6d]], [[3p6e]] - hAFABP + propionate derivative<br /> | **[[3p6d]], [[3p6e]] - hAFABP + propionate derivative<br /> | ||
**[[3p6f]] - hAFABP + phenyl-butyrate<br /> | **[[3p6f]] - hAFABP + phenyl-butyrate<br /> | ||
**[[3p6g]], [[3p6h]] - hAFABP + ibuprofen<br /> | **[[3p6g]], [[3p6h]] - hAFABP + ibuprofen<br /> | ||
**[[2qm9]] - mAFABP + troglitazone <br /> | **[[6ayl]] - hAFABP + fluorescein <br /> | ||
**[[1lib]], [[1alb]] – mAFABP<br /> | |||
**[[1g7n]], [[1ab0]], [[1acd]] - mAFABP (mutant) <br />**[[2qm9]] - mAFABP + troglitazone <br /> | |||
**[[2q9s]], [[1lid]], [[1lie]], [[1lif]], [[1adl]] - mAFABP + fatty acid<br /> | **[[2q9s]], [[1lid]], [[1lie]], [[1lif]], [[1adl]] - mAFABP + fatty acid<br /> | ||
**[[1g74]] - mAFABP (mutant) + fatty acid <br /> | **[[1g74]] - mAFABP (mutant) + fatty acid <br /> | ||
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*Ileal bile acid-binding protein (Gastrotropin) | *Ileal bile acid-binding protein (Gastrotropin) | ||
**[[1o1u]], [[5l8i]] – hIBABP <br /> | |||
**[[1o1v]] – hIBABP + cholytaurine<br /> | |||
**[[2mm3]], [[5l8o]] – hIBABP + cholate<br /> | |||
**[[5l8n]] – hIBABP + inhibitor<br /> | |||
**[[1eal]] – pIBABP - pig <br /> | |||
**[[1eio]] – pIBABP + cholate<br /> | |||
**[[3elx]] – zIBABP <br /> | **[[3elx]] – zIBABP <br /> | ||
**[[3elz]], [[3em0]] – zIBABP + cholate<br /> | **[[3elz]], [[3em0]] – zIBABP + cholate<br /> | ||
*Other fatty acid-binding protein | *Other fatty acid-binding protein | ||
Revision as of 13:05, 26 June 2019
Fatty acid-binding protein (FABP) are carrier proteins for fatty acids and other lipophilic substances. They facilitate the transfer of fatty acids between extra- and intracellular membranes. FABS coordinate lipid trafficking and signaling in cells[1]. Various FABS differ in their tissue expression. IFABP is intestinal; HFABP is heart-type; BFABP is brain-type; LFABP is liver-type; AFABP is adipocyte; LMDABP is from flight muscle; TFABP is from testis. RelevanceSome FABSs are linked to metabolic and inflammatory pathways. Structural insightsThe (Hydrophobic, Polar)[2]. 3D structures of fatty acid-binding proteinFatty acid-binding protein 3D structures
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3D structures of fatty acid-binding protein3D structures of fatty acid-binding protein
Updated on 26-June-2019
ReferencesReferences
- ↑ Chmurzynska A. The multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphism. J Appl Genet. 2006;47(1):39-48. PMID:16424607 doi:http://dx.doi.org/10.1007/BF03194597
- ↑ Balendiran GK, Schnutgen F, Scapin G, Borchers T, Xhong N, Lim K, Godbout R, Spener F, Sacchettini JC. Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein. J Biol Chem. 2000 Sep 1;275(35):27045-54. PMID:10854433 doi:10.1074/jbc.M003001200