Integrin: Difference between revisions

Revision as of 12:39, 22 July 2018

Function

Integrins (IG) are receptors which mediate the attachment between cells and between cells and the extracellular matrix. They are involved in cellular signaling and cell cycle^[1]. IGs contain α and β chain. IG subunits span the cell membrane. Both subunits bind divalent cations some of which bind the ligands which interact with IG. Some IGs contain an insertion domain named I domain. For more details see Molecular Playground/IntegrinBeta1.

For some details on the interaction of a targeting peptide with integrin see Molecular Playground/Targeting Peptide.

Disease

Defective integrin is the cause of the skin disease epidermolysis bullosa, of congenital muscular dystrophy. Overexpression of integrin is correlated with some types of cancer and enhanced bone resorption in osteoporosis^[2]. Defective integrin is involved in periodontal diseases^[3].

Structural highlights

The interactions of integrin with ligands are dependent on the presence of divalent ions^[4].

. Water molecules shown as red spheres.

Structure of human integrin CD11a I domain dimer complex with Mg+2 (light green) and Cl- (dark green) ions (PDB entry 1zoo)

Drag the structure with the mouse to rotate

3D structures of integrin3D structures of integrin

Updated on 22-July-2018

IG CR3
- 1ido – hIG I domain + Mg – human
- 1jlm - hIG I domain + Mn
IG CD11a or IG α-L
- 1lfa - hIG I domain + Mn
- 1zon - hIG I domain
- 1zoo, 1zop, 3f74 - hIG I domain + Mg
- 1mq9 - hIG I domain (mutant) + Mn
- 1mjn - hIG I domain (mutant) + Mg
- 1mqa - hIG I domain (mutant)
- 2k8o – hIG cytoplasmic domain (mutant) – NMR
IG CD11a complexes
- 1cqp - hIG I domain + lovastatin + Mg
- 1mq8, 3bn3, 3tcx - hIG I domain (mutant) + intracellular adhesion molecule + Mg
- 1t0p - hIG I domain + intracellular adhesion molecule-3 + Mg
- 1rd4, 2ica, 3bqm, 3bqn, 3e2m - hIG I domain + inhibitor
- 2o7n, 3m6f - hIG I domain + antagonist
- 1xdd, 1xdg, 1xuo - hIG I domain + inhibitor + Mg
- 4ixd - hIG I domain + activator + Mg
- 3f78 - hIG I domain + anesthetic + Mg
- 3eoa, 3eob - hIG I domain + antibody
- 3hi6 - hIG I domain (mutant) + antibody + Mn
IG CD11b
- 1bho - hIG I domain + Mg
- 1bhq - hIG I domain + Cd
- 1m1u - hIG I domain (mutant) + Ca
- 1n9z - hIG I domain (mutant) + Mg
- 1idn, 1na5 - hIG I domain
- 1mf7 - hIG I domain (mutant)
IG CD11c
- 1n3y - hIG I domain (mutant)
IG α-1 (CD49a)
- 1ck4 - rIG I domain – rat
- 4a0q - hIG I domain (mutant) + Mg
- 2l8s - hIG transmembrane domain – NMR
- 5hgj - hIG VWFA domain
- 1mhp - rIG I domain (mutant) + antibody + Mn
- 2b2x - rIG I domain (mutant) + antibody + Mg
- 2m32 - hIG I domain + collagen peptide
IG α-2 (CD49b)
- 4bj3, 5e6x, 5e6v - hIG I domain
- 1dzi, 4bj3 - hIG I domain + collagen peptide
- 1v7p - hIG I domain (mutant) + EMS16 + Mn
- 5thp - hIG residues 170-366 + rhodocetin
IG α-2b
- 2k1a - hIG transmembrane domain – NMR
IG α-1 β-1 (CD49a-CD49b)
- 1qc5, 1qcy - hIG I domain (mutant) + Mg
- 1pt6 - hIG I domain + Mg
IG α-2 (CD49b) β
- 5hj2 - hIG I domain
- 1aox - hIG I domain (mutant) + Mg
- 2k1a - hIG transmembrane domain – NMR
IG α-2b β-3 (CD61)
- 1kup, 1kuz – hIG proximal domain – NMR
- 1m8o - hIG cytoplasmic domain – NMR
- 4cak – hIG – Cryo-EM
- 2k9j, 2knc - hIG transmembrane domain – NMR
- 1tye, 3fcu, 3fcs – hIG + Mg
- 3fc3 – hIG (mutant) + Mg
- 2vc2, 2vdk, 2vdl, 3nid, 3nif, 3nig, 3zdx, 3zdy, 3zdz, 3ze0, 3ze1, 3ze2, 5hdb – hIG headpiece + antibody + Mg
- 4z7q, 4z7o, 4z7n – hIG headpiece + antibody + Mg + tetrapeptide
- 2vdm, 2vdn, 3t3m, 3t3p – hIG headpiece + antibody + antagonist + Mg
- 2vdo, 2vdp, 2vdq, 2vdr – hIG headpiece + antibody + fibrinogen peptide + Mg
IG α-4

- 4irz - hIG + antibody
IG α-4 (CD49d) β-7
- 3v4p - hIG headpiece (mutant) + antibody + Mg
- 3v4v - hIG headpiece (mutant) + antibody + inhibitor + Mg
IG α-5 (CD49e) β-1 (CD29)
- 4wjk - hIG headpiece (mutant) + Mg
- 4wk0, 4wk2, 4wk4 - hIG headpiece (mutant) + peptide + Mg
- 3vi3 - hIG headpiece + antibody + Mg
- 3vi4 - hIG headpiece + antibody + peptide + Mg
IG α-5 (CD49e) β-3 (CD61)
- 3ije – hIG + Ca
- 1m1x - hIG extracellular domain + Mn
- 4mmx, 4mmy, 4mmz - hIG extracellular domain + Mn + fibronectin domain 10
- 4o02, 6avu, 6avr, 6avq - hIG extracellular domain + antibody
- 1u8c – hIG psi domain + Ca
- 1jv2 - hIG I domain + platelet membrane glycoprotein IIIA + Ca
- 1l5g - hIG I domain + tripeptide + Mn
IG α-5 β-6
- 4um8 – hIG headpiece (mutant) + Ni
- 5ffg – hIG headpiece + Ca
- 4um9 – hIG headpiece (mutant) + Mg + transforming growth factor β 3
- 5neu, 5net, 5ner, 5nem – hIG headpiece + foot-and-mouth virus – Cryo EM
- 5ffo – hIG headpiece + TGF-beta-1
IG α-L
- 4ixd – hIG I domain
- 5e6s, 5e6r – hIG AI, headpiece,pocket domains + Mg
- 2m3e – hIG transmembrane domain - NMR
IG α-L β-2
- 5e6u – hIG headpiece (mutant) + Ni
IG α-M
- 3q3g, 3qa3 – hIG + antibody
- 4m76 – hIG + complement C3
- 2lke, 2lkj – hIG cytoplasmic domain – NMR
- 4xw2 – hIG + simvastatin
IG α-X
- 2luv – hIG cytoplasmic domain – NMR
IG α-X β-2 (CD18)
- 3k6s, 3k71, 3k72, 5es4 – hIG + Mg
- 4neh, 4nen – hIG (mutant) + Mg
IG α-V β-3
- 4g1e, 4g1m – hIG + Ni
IG β-1D
- 3g9w – hIG cytoplasmic tail + talin 2 F2-F3 domain
IG β-2 (CD18)
- 2p26, 2p28, 5e6w – hIG phe2 + phe3 domains
- 1yuk – hIG chain A PSI domain + chain B I-EGF domain
IG β-3 (CD61)
- 1s4x, 2kv9, 2ljd, 2lje, 2ljf – hIG cytoplasmic domain – NMR
- 2rmz, 2rn0 – hIG transmembrane domain – NMR
- 2l91 - hIG transmembrane domain (mutant) – NMR
- 2l1c – hIG cytoplasmic tail + SHC
- 2mtp – hIG cytoplasmic tail (mutant) + hIG α-2 β peptide+ filamin rod domain
IG β-4 (CD104)
- 2f7q, 3f7r, 1qg3, 3f7q, 4wtw, 4wtx - hIG fibronectin type III domain
- 2yrz – hIG fibronectin type III domain – NMR
- 3f7p, 4q58 - hIG fibronectin type III domain + plectin-1
- 3fq4, 3fso, 3h6a – hIG Calx-β domain
IG β-7
- 2brq, 2jf1 – hIG cytoplasmic tail + filamin rod domain

ReferencesReferences

↑ Humphries MJ. Integrin structure. Biochem Soc Trans. 2000;28(4):311-39. PMID:10961914
↑ Hillis GS, MacLeod AM. Integrins and disease. Clin Sci (Lond). 1996 Dec;91(6):639-50. PMID:8976799
↑ Larjava H, Koivisto L, Heino J, Hakkinen L. Integrins in periodontal disease. Exp Cell Res. 2014 Jul 15;325(2):104-10. doi: 10.1016/j.yexcr.2014.03.010. Epub, 2014 Mar 22. PMID:24662197 doi:http://dx.doi.org/10.1016/j.yexcr.2014.03.010
↑ Humphries MJ. Integrin structure. Biochem Soc Trans. 2000;28(4):311-39. PMID:10961914

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

[1] Humphries MJ. Integrin structure. Biochem Soc Trans. 2000;28(4):311-39. PMID:10961914

[2] Hillis GS, MacLeod AM. Integrins and disease. Clin Sci (Lond). 1996 Dec;91(6):639-50. PMID:8976799

[3] Larjava H, Koivisto L, Heino J, Hakkinen L. Integrins in periodontal disease. Exp Cell Res. 2014 Jul 15;325(2):104-10. doi: 10.1016/j.yexcr.2014.03.010. Epub, 2014 Mar 22. PMID:24662197 doi:http://dx.doi.org/10.1016/j.yexcr.2014.03.010

[4] Humphries MJ. Integrin structure. Biochem Soc Trans. 2000;28(4):311-39. PMID:10961914

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@@ Line 75: / Line 75: @@
 **[[1dzi]], [[4bj3]] - hIG I domain + collagen peptide<br />
 **[[1v7p]] - hIG I domain (mutant) + EMS16 + Mn<br />
+**[[5thp]] - hIG residues 170-366 + rhodocetin <br />
 *IG α-2b
@@ Line 87: / Line 88: @@
 *IG α-2 (CD49b) β
+**[[5hj2]] - hIG I domain<br />
 **[[1aox]] - hIG I domain (mutant) + Mg<br />
-**[[1s4w]], [[1dpk]] - hIG cytoplasmic domain - NMR<BR />
+**[[2k1a]] - hIG transmembrane domain – NMR<br />
-**[[1dpq]] - hIG cytoplasmic domain (mutant) – NMR<br />
 *IG α-2b β-3 (CD61)
@@ Line 125: / Line 126: @@
 **[[1m1x]] - hIG extracellular domain + Mn<br />
 **[[4mmx]], [[4mmy]], [[4mmz]] - hIG extracellular domain + Mn + fibronectin domain 10<br />
-**[[4o02]] - hIG extracellular domain + Mn + antibody<br />
+**[[4o02]], [[6avu]], [[6avr]], [[6avq]] - hIG extracellular domain + antibody<br />
 **[[1u8c]] – hIG psi domain + Ca<br />
 **[[1jv2]] - hIG I domain + platelet membrane glycoprotein IIIA + Ca<br />
@@ Line 135: / Line 136: @@
 **[[5ffg]] – hIG headpiece + Ca<br />
 **[[4um9]] – hIG headpiece (mutant) + Mg + transforming growth factor β  3<br />
+**[[5neu]], [[5net]], [[5ner]], [[5nem]] – hIG headpiece + foot-and-mouth virus – Cryo EM<br />
+**[[5ffo]] – hIG headpiece + TGF-beta-1<br />
 *IG α-L
@@ Line 172: / Line 175: @@
 *IG β-2 (CD18)
-**[[2p26]], [[2p28]] – hIG phe2 + phe3 domains<br />
+**[[2p26]], [[2p28]], [[5e6w]] – hIG phe2 + phe3 domains<br />
 **[[1yuk]] – hIG chain A PSI domain + chain B I-EGF domain<br />