6avr

Human alpha-V beta-3 Integrin (intermediate conformation) in complex with the therapeutic antibody LM609Human alpha-V beta-3 Integrin (intermediate conformation) in complex with the therapeutic antibody LM609

6avr, resolution 35.00Å Show:Asymmetric Unit Biological Assembly Structural highlights 6avr is a 4 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 35Å Experimental data: Check Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function ITAV_HUMAN The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. See Also Antibody 3D structures Integrin 3D structures