Tumor necrosis factor receptor: Difference between revisions

Revision as of 16:54, 1 March 2017

Function

Tumor necrosis factor receptor (TNFR) or death receptor is a trimeric cytokine receptor which binds TNF^[1]. TNFR family contains several members and superfamily (TNFRSF) members.

TNFRSF 1 is called Lymphotoxin-α or TNF-β;
TNFRSF 3 is called TNFR-III;
TNFRSF 4 is called OX40L receptor;
TNFRSF 5 is called CD40L receptor;
TNFRSF 6 is called Fas;
TNFRSF 9 is called 4-1BBL;
TNFRSF 10B is called Dr5;
TNFRSF 11 is called RANKL;
TNFRSF 11A is called RANK;
TNFRSF 11B is called Osteoprotegerin;
TNFRSF 12 is called TWEAK;
TNFRSF 12A is called TWEAKR;
TNFRSF 13 is called APRIL;
TNFRSF 13B is called BAFF or sTALL-1;
TNFRSF 13C is called BAFF receptor;
TNFRSF 14 is called LIGHT;
TNFRSF 16 is called Nerve growth factor receptor;
TNFRSF 18 is called GITRL;
TNFRSF 21 is called Dr6;

Relevance

TRAPS - a condition characterized by recurrent episodes of fever is associated with TNFR^[2].

Structural highlights

The extracellular domain of TNFR contains 2 to 6 cysteine-rich domains (CRD). The CRD domains are ca. 40 amino-acid long and contain 4-6 cysteine residues. The CRDs are involved in binding of TNF^[3].

Structure of human TNFR extracellular domain complex with sulfate and Mg+2 ion (green) (PDB code 1ext).

Drag the structure with the mouse to rotate

3D structures of tumor necrosis factor receptor3D structures of tumor necrosis factor receptor

Updated on 01-March-2017

Tumor necrosis factor receptor 1
- 1ncf – hTNFR-1 residues 12-172 (mutant) – human
- 1ich – hTNFR-1 death domain (mutant) - NMR
- 2eqp – hTNFR-1 residues 28-70 – NMR
- 1ext – hTNFR-1 extracellular domain
- 1ft4 – hTNFR-1 extracellular domain + inhibitor
- 3on9 – evTNFR SECRET domain – ectromelia virus
- 3ona – evTNFR SECRET domain + CX3CL1
Tumor necrosis factor receptor superfamily 1 (lymphotoxin-α, TNF-β)
- 1tnr – hTNFRSF-1 + TNFβ
- 4mxv – hTNFSF-1 extracellular domain + antibody - human
- 4mxw – hTNFSF-1 extracellular domain + antibody + TNFR-III
Tumor necrosis factor receptor superfamily 1B
- 3alq – hTNFRSF-1B extracellular domain + TNF
Tumor necrosis factor receptor superfamily-4 (OX40L receptor)
- 2hew – mTNFSF-4 extracellular domain - mouse
- 2hev – hTNFSF-4 extracellular domain + OX40 ligand
- 2hey – mTNFSF-4 extracellular domain + hOX40 ligand
Tumor necrosis factor receptor superfamily-5 (CD40L receptor)
- 1aly – hTNFSF-5 extracellular domain
- 1i9r, 5dmi, 5dmj, 5ihl – hTNFSF-5 extracellular domain + antibody
- 3lkj – hTNFSF-5 extracellular domain + inhibitor
- 3qd6 – hTNFRSF-5 extracellular domain + CD40 ligand
Tumor necrosis factor receptor superfamily-6 (Fas)
- 3thm, 3tje – hTNFRSF-6 extracellular domain + antibody
- 3ezq – hTNFRSF-6 Fas DD domain + FADD
- 3oq9 – mTNFRSF-6 Fas DD domain + FADD - mouse
Tumor necrosis factor receptor superfamily-6B
- 3mhd – hTNFRSF-6B extracellular domain
- 4msv – hTNFRSF-6B extracellular domain + hTNFRSF-6 extracellular domain
- 4kgg, 4kgq, 4j6g – hTNFRSF-6B extracellular domain + hTNFRSF-14 extracellular domain
- 3mi8, 3k51 – hTNFRSF-6B extracellular domain + hTNFRSF-15 extracellular domain
- 5l36 – hTNFRSF-6B extracellular domain + hTNF ligand SF-6 extracellular domain
Tumor necrosis factor receptor superfamily-9 (4-1BBL)
- 2x29 – hTNFSF-9 extracellular domain (mutant)
Tumor necrosis factor receptor superfamily-10B (Dr5)
- 2h9g, 4od2, 1za3, 3x3f – hTNFRSF-10B extracellular domain + antibody
- 1d0g – hTNFRSF-10B extracellular domain + apoptosis-2 ligand
- 1d4v – hTNFRSF-10B extracellular domain + TNF-related apoptosis inducing ligand
- 4i9x – hTNFRSF-10B extracellular domain + UL141
- 4n90 – hTNFRSF-10B + hTNFRSF-10 + antibody
Tumor necrosis factor receptor superfamily-11 (RANKL)
- 1jtz, 1iqa, 1s55 – mTNFSF-11 receptor-binding domain
- 3me2, 3qbq, 4giq – mTNFSF-11 receptor-binding domain + RANK
- 4e4d – mTNFSF-11 receptor-binding domain + osteoprotegerin
- 3urf – hTNFSF-11 receptor-binding domain + osteoprotegerin
Tumor necrosis factor receptor superfamily-11A (RANK)
- 3me4 – mTNFRSF-11A extracellular domain
- 5bnq – mTNFRSF-11A extracellular domain + TNF ligand SF-11
Tumor necrosis factor receptor superfamily-11B (Osteoprotegerin)
- 3urf – hTNFRSF-11B extracellular domain + TNFRSF-11B ligand
- 4e4d – mTNFRSF-11B extracellular domain + TNFRSF-11B ligand
TNFSF-12 superfamily member 12 (TWEAK)
- 4ht1 – hTNFSF-12 extracellular domain + antibody
Tumor necrosis factor receptor superfamily-12A (TWEAKR)
- 2rpj, 2kmz, 2epq – hTNFRSF-12A cysteine-rich domain – NMR
TNFSF-13 superfamily member 13 (APRIL)
- 1u5x, 1u5y, 1u5z – mTNFSF-13 extracellular domain
- 1xu1 – mTNFSF-13 extracellular domain + TNFSF-13B
- 1xu2 – mTNFSF-13 extracellular domain + BCMA
- 3k48 – mTNFSF-13 extracellular domain + peptide
- 4zch – hTNFSF-13 extracellular domain + TNFSF-13B
TNFSF-13B superfamily member 13B (BAFF, sTALL-1)
- 1jh5, 1kxg, 1kd7, 4zch – hTNFSF-13B extracellular domain
- 1oqd – hTNFSF-13B extracellular domain + B-cell maturation protein
- 1oqe – hTNFSF-13B extracellular domain + hTNFRSF-13C
- 4v46 – hTNFSF-13B extracellular domain + hTNFRSF-13C + BAFF
- 1osg, 3v56 – hTNFSF-13B extracellular domain + hTNFRSF-13C peptide
Tumor necrosis factor receptor superfamily-13C (BAFF receptor)
- 1osx – hTNFRSF-13C extracellular domain - NMR
- 2hfg – hTNFL cysteine-rich domain + antibody
Tumor necrosis factor receptor superfamily-14 (LIGHT)
- 4fhq, 4en0 – hTNFRSF-14 extracellular domain
- 2aw2 – hTNFRSF-14 extracellular domain + B and T lymphocyte attenuator
- 4rsu – hTNFRSF-14 extracellular domain + TNFRSF-14 ligand
- 4kg8 – hTNFSF-14 extracellular domain (mutant)
- 4j6g – hTNFSF-14 extracellular domain + DCR3
- 4kgq, 4kgg – hTNFSF-14 extracellular domain (mutant) + DCR3
Tumor necrosis factor receptor superfamily-16 (nerve growth factor receptor)
- 4f42, 4f44 – hTNFRSF-16 death domain
- 2n97 – hTNFRSF-16 death domain - NMR
- 1sg1, 3ij2 – hTNFRSF-16 + beta nerve growth factor
- 3buk – hTNFRSF-16 + neurotrophin-3
- 2n80 – hTNFRSF-16 death domain + rho GDP-dissociation inhibitor - NMR
- 2n83 – hTNFRSF-16 death domain + receptor interacting Ser/Thr protein kinase - NMR
Tumor necrosis factor receptor superfamily-17
- 2kn1 – hTNFRSF-17 extracellular domain - NMR
- 4zfo – hTNFRSF-17 extracellular domain + antibody
Tumor necrosis factor receptor superfamily-18 (GITRL)
- 4db5 – TNFRSF-18 – rabbit
- 4e4s – TNFRSF-18 – pika
- 4g4f – TNFRSF-18 – bushbaby
- 3fc0, 2qdn, 3b9i – mTNFRSF-18
- 2q1m, 3b93, 3b94 – hTNFRSF-18 extracellular domain
- 2r30, 2r32 – hTNFRSF-18 extracellular domain (mutant)
Tumor necrosis factor receptor superfamily-21 (Dr6)
- 3u3p, 3u3q, 3u3s, 3u3t, 3u3v – hTNFRSF-21 cysteine-rich domain
- 2dbh – hTNFRSF-21 CARD-like domain - NMR
- 3qo4 – hTNFRSF-21 cysteine-rich domain
- 4yn0 – hTNFRSF-21 cysteine-rich domain + amyloid beta A4 protein

ReferencesReferences

↑ Wallach D, Varfolomeev EE, Malinin NL, Goltsev YV, Kovalenko AV, Boldin MP. Tumor necrosis factor receptor and Fas signaling mechanisms. Annu Rev Immunol. 1999;17:331-67. PMID:10358762 doi:http://dx.doi.org/10.1146/annurev.immunol.17.1.331
↑ Lopalco G, Rigante D, Vitale A, Frediani B, Iannone F, Cantarini L. Tumor necrosis factor receptor-associated periodic syndrome managed with the couple canakinumab-alendronate. Clin Rheumatol. 2015 Apr;34(4):807-9. doi: 10.1007/s10067-014-2556-8. Epub 2014, Mar 11. PMID:24609716 doi:http://dx.doi.org/10.1007/s10067-014-2556-8
↑ Naismith JH, Devine TQ, Kohno T, Sprang SR. Structures of the extracellular domain of the type I tumor necrosis factor receptor. Structure. 1996 Nov 15;4(11):1251-62. PMID:8939750

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

[1] Wallach D, Varfolomeev EE, Malinin NL, Goltsev YV, Kovalenko AV, Boldin MP. Tumor necrosis factor receptor and Fas signaling mechanisms. Annu Rev Immunol. 1999;17:331-67. PMID:10358762 doi:http://dx.doi.org/10.1146/annurev.immunol.17.1.331

[2] Lopalco G, Rigante D, Vitale A, Frediani B, Iannone F, Cantarini L. Tumor necrosis factor receptor-associated periodic syndrome managed with the couple canakinumab-alendronate. Clin Rheumatol. 2015 Apr;34(4):807-9. doi: 10.1007/s10067-014-2556-8. Epub 2014, Mar 11. PMID:24609716 doi:http://dx.doi.org/10.1007/s10067-014-2556-8

[3] Naismith JH, Devine TQ, Kohno T, Sprang SR. Structures of the extracellular domain of the type I tumor necrosis factor receptor. Structure. 1996 Nov 15;4(11):1251-62. PMID:8939750

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@@ Line 24: / Line 24: @@
 * '''TNFRSF 21''' is called '''Dr6''';<br />
+==See also [[Tumor necrosis factor ligand superfamily]]==
 == Relevance ==
 TRAPS - a condition characterized by recurrent episodes of fever is associated with TNFR<ref>PMID:24609716</ref>.

Tumor necrosis factor receptor: Difference between revisions

Revision as of 16:54, 1 March 2017

Contents

Function

See also Tumor necrosis factor ligand superfamily

Relevance

Structural highlights

3D structures of tumor necrosis factor receptor3D structures of tumor necrosis factor receptor

ReferencesReferences

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Tumor necrosis factor receptor: Difference between revisions

Revision as of 16:54, 1 March 2017

Function

See also Tumor necrosis factor ligand superfamily

Relevance

Structural highlights

3D structures of tumor necrosis factor receptor3D structures of tumor necrosis factor receptor

ReferencesReferences

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