Tumor necrosis factor ligand superfamily

Function

Tumor necrosis factor ligand superfamily (TNFLS) is a family of TNF-like ligands. These cytokines cause wide-ranging long-term cellular activities in cells such as differentiation, proliferation or death^[1], ^[2]. The TNFLS are ligands for the TNF receptors.

3D structures of tumor necrosis factor ligand superfamily

Tumor necrosis factor ligand superfamily 3D structures

Tumor necrosis factor ligand superfamily member 10 (grey, green, pink) complex with TNF receptor TRAIL (wheat, magenta, cyan), Zn+2 (grey) and Cl- (green) ions (PDB code 4e4d)

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ReferencesReferences

↑ Idriss HT, Naismith JH. TNF alpha and the TNF receptor superfamily: structure-function relationship(s). Microsc Res Tech. 2000 Aug 1;50(3):184-95. PMID:10891884 doi:<184::AID-JEMT2>3.0.CO;2-H http://dx.doi.org/10.1002/1097-0029(20000801)50:3<184::AID-JEMT2>3.0.CO;2-H
↑ Gruss HJ. Molecular, structural, and biological characteristics of the tumor necrosis factor ligand superfamily. Int J Clin Lab Res. 1996;26(3):143-59. PMID:8905447

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Michal Harel

[1] Idriss HT, Naismith JH. TNF alpha and the TNF receptor superfamily: structure-function relationship(s). Microsc Res Tech. 2000 Aug 1;50(3):184-95. PMID:10891884 doi:<184::AID-JEMT2>3.0.CO;2-H http://dx.doi.org/10.1002/1097-0029(20000801)50:3<184::AID-JEMT2>3.0.CO;2-H

[2] Gruss HJ. Molecular, structural, and biological characteristics of the tumor necrosis factor ligand superfamily. Int J Clin Lab Res. 1996;26(3):143-59. PMID:8905447

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