Fatty acid-binding protein: Difference between revisions
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<StructureSection load='1fe3' size='350' side='right' scene='48/487562/Cv/3' caption='Human brain-type fatty acid-binding protein complex with oleate (PDB code [[1fe3]]) '> | <StructureSection load='1fe3' size='350' side='right' scene='48/487562/Cv/3' caption='Human brain-type fatty acid-binding protein complex with oleate (PDB code [[1fe3]]) '> | ||
'''Fatty acid-binding protein''' (FABP) are carrier proteins for fatty acids and other lipophilic substances. They facilitate the transfer of fatty acids between extra- and intracellular membranes. FABS coordinate lipid trafficking and signaling in cells<ref>PMID:16424607</ref>. Various FABS differ in their tissue expression. '''IFABP''' is intestinal; '''HFABP''' is heart-type; '''BFABP''' is brain-type; '''LFABP''' is liver-type; '''AFABP''' is adipocyte; '''LMDABP''' is from flight muscle; '''TFABP''' is from testis | '''Fatty acid-binding protein''' (FABP) are carrier proteins for fatty acids and other lipophilic substances. They facilitate the transfer of fatty acids between extra- and intracellular membranes. FABS coordinate lipid trafficking and signaling in cells<ref>PMID:16424607</ref>. Various FABS differ in their tissue expression. '''IFABP''' is intestinal; '''HFABP''' is heart-type; '''BFABP''' is brain-type; '''LFABP''' is liver-type; '''AFABP''' is adipocyte; '''LMDABP''' is from flight muscle; '''TFABP''' is from testis. | ||
== Relevance == | == Relevance == | ||
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**[[3elx]] – zIBABP <br /> | **[[3elx]] – zIBABP <br /> | ||
**[[3elz]], [[3em0]] – zIBABP + cholate<br /> | **[[3elz]], [[3em0]] – zIBABP + cholate<br /> | ||
*Other fatty acid-binding protein | *Other fatty acid-binding protein | ||
Revision as of 12:22, 22 December 2016
Fatty acid-binding protein (FABP) are carrier proteins for fatty acids and other lipophilic substances. They facilitate the transfer of fatty acids between extra- and intracellular membranes. FABS coordinate lipid trafficking and signaling in cells[1]. Various FABS differ in their tissue expression. IFABP is intestinal; HFABP is heart-type; BFABP is brain-type; LFABP is liver-type; AFABP is adipocyte; LMDABP is from flight muscle; TFABP is from testis. RelevanceSome FABSs are linked to metabolic and inflammatory pathways. Structural insightsThe (Hydrophobic, Polar)[2]. |
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3D structures of fatty acid-binding protein3D structures of fatty acid-binding protein
Updated on 22-December-2016
ReferencesReferences
- ↑ Chmurzynska A. The multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphism. J Appl Genet. 2006;47(1):39-48. PMID:16424607 doi:http://dx.doi.org/10.1007/BF03194597
- ↑ Balendiran GK, Schnutgen F, Scapin G, Borchers T, Xhong N, Lim K, Godbout R, Spener F, Sacchettini JC. Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein. J Biol Chem. 2000 Sep 1;275(35):27045-54. PMID:10854433 doi:10.1074/jbc.M003001200