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| {{STRUCTURE_3gpt| PDB=3gpt | SIZE=400| SCENE= |right|CAPTION=Yeast proteasome 20S core complex with salinosporamide derivative, [[3gpt]] }} | | {{STRUCTURE_3gpt| PDB=3gpt | SIZE=400| SCENE= |right|CAPTION=Yeast proteasome 20S core complex with salinosporamide derivative, [[3gpt]] }} |
| | == Function == |
| | [[Proteasome]] (PRTS) are large protein complexes which degrade unneeded proteins into small polypeptides<ref>PMID:22350895</ref>. The '''26S PRTS''' is composed of a central '''20S core particle''' which contains 4 stacked rings each with several members and two 19S caps. The 19S cap is composed of a base with 10 proteins six of which are ATPases and a lid which contains 9 proteins which bind polyubiquitin. <br /> |
| | For more details see [[3unb]]. |
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| [[Proteasome]] (PRTS) are large protein complexes which degrade unneeded proteins into small polypeptides<ref>PMID:22350895</ref>. The '''26S PRTS''' is composed of a central '''20S core particle''' which contains 4 stacked rings each with several members and two 19S caps. The core particle two outer rings contain 7 α subunits which form the PRTS gate. The two inner rings contain 6 β subunits with protease activity. The 19S cap is composed of a base with 10 proteins six of which are ATPases and a lid which contains 9 proteins which bind polyubiquitin. <br />
| | == Structural highlights == |
| For more details see [[3unb]].
| | The core particle two outer rings contain 7 α subunits (Y7, Y13, PRE6, PRE5, PUP2, C1, C7-α) which form the PRTS gate. The two inner rings contain 7 β subunits (PRE2, PRE4, PRE3, PUP1, PUP3, C5, C11) with protease activity<ref>PMID:8811196</ref>. |
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| == 3D Structures of Proteasome == | | == 3D Structures of Proteasome == |
Revision as of 10:33, 14 July 2016
Template:STRUCTURE 3gpt
FunctionFunction
Proteasome (PRTS) are large protein complexes which degrade unneeded proteins into small polypeptides[1]. The 26S PRTS is composed of a central 20S core particle which contains 4 stacked rings each with several members and two 19S caps. The 19S cap is composed of a base with 10 proteins six of which are ATPases and a lid which contains 9 proteins which bind polyubiquitin.
For more details see 3unb.
Structural highlightsStructural highlights
The core particle two outer rings contain 7 α subunits (Y7, Y13, PRE6, PRE5, PUP2, C1, C7-α) which form the PRTS gate. The two inner rings contain 7 β subunits (PRE2, PRE4, PRE3, PUP1, PUP3, C5, C11) with protease activity[2].
3D Structures of Proteasome3D Structures of Proteasome
Updated on 14-July-2016
{"openlevels":0}
- Proteasome 20S particle
- 3mfe, 3mi0, 2fhg – Mt20S core – Mycobacterium tuberculosis
- 3gpt, 3gpw, 1g0u – y20S core - yeast
- 1ryp, 3wxr, 4qux, 4quy, 4qv0, 4qv1, 4qv3, 4qv4, 4qv5, 4qv6, 4qv7, 4qv8, 4qv9 - y20S core (mutant)
- 4r3o – h20S – human
- 3mka, 3hfa – Mt20S core (mutant)
- 3c91, 3c92, 1pma, 3j9i – Ta20S core - Themoplasma acidophilum
- 3h4p – 20S core – Methanocaldococcus janaschii
- 2h6j, 1q5r – Re20S core (mutant) – Rhodococcus erythropolis
- 1q5q - Re20S core
- 1j2q – Af20S core - Archaeoglobus fulgidus
- 1iru – 20S core - bovine
- 3une – m20S core – mouse
- 3unh – m20S core (immuno)
- Proteasome 20S+activator protein
- Proteasome 20S+inhibitor
- 3hye, 3gpj, 3dy3, 3dy4, 3e47, 3d29, 3bdm, 2zcy, 2gpl, 2fak, 2f16, 1jd2, 1g65, 3mg0, 3mg4, 3mg6, 3mg7, 3mg8, 3oeu, 3oev, 3okj, 3shj, 3un4, 3un8, 3sdi, 3sdk, 4fzc, 4fzg, 4gk7, 4eu2, 4inr, 4int, 4inu, 4jsq, 4jsu, 4jt0, 4qwx, 4qzz, 4r17, 4r18, 4rur, 5ahj – y20S core+inhibitor
- 4qxj, 4qz0, 4qz1, 4qz2, 4qz3, 4qz4, 4qz5, 4qz6, 4qz7, 4qzw, 4qzx, 4r00, 4r02 – y20S (mutant) + inhibitor
- 3tdd, 4j70 - y20S core + belactosin
- 4hnp, 4hrc, 4hrd, 4lqi, 4ltc, 4q1s - y20S core + antibiotics
- 4nnn, 4nnw, 4no1, 4no6, 4no8, 4no9, 4qby, 4qlq, 4qls, 4qlt, 4qlu, 4qlv - y20S core+ peptide inhibitor
- 3h6f, 3h6i, 3hf9, 2fhh, 3krd – Mt20S core+inhibitor
- 3nzj, 3nzw, 3nzx - y20S + TMC-95A mimic ligand
- 2zcy – y20S+syringolin
- 4qvl, 4qw4 – y20S + lymphoma drug
- 4qvm, 4qvn, 4qvp, 4qvq, 4qvv, 4qvw, 4qvy, 4qw0, 4qw1, 4qw3, 4qw5, 4qw6, 4qw7, 4qwf, 4qwg, 4qwi, 4qwj, 4qwk, 4qwl, 4qwr, 4qws, 4qwu – y20S (mutant) + lymphoma drug
- 4r67 – h20S + cancer drug
- 3unb, 3unf – m20S + inhibitor
- Proteasome partial 20S particle
- 2ku1, 2ku2 – Taa-PRTS chains A-G
- 3fp9 – MtATPase chains A-L
- 1j2p – Af α subunit
- 2jay – Mt β subunit
- 2kqz, 2kr0 – hPRTS ubiquitin receptor domain
- Proteasome partial 26S particle
- 1p9c – hPRTS subunit 4 C-terminal
- 1p9d - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain
- 1uel - hPRTS subunit 4 C-terminal + HHR23A ubiquitin-like domain - NMR
- 1yx4 - hPRTS subunit 4 – NMR
- 1yx5, 1yx6, 2kde, 2kdf - hPRTS subunit 4+ubiquitin – NMR
- 2o95, 2o96 - hPRTS subunit 7
- 3kw6 - hPRTS subunit 8
- 2krk - hPRTS subunit 8 – NMR
- 1qym, 1uoh - hPRTS subunit 10
- 1tr4 - hPRTS subunit 10 – NMR
- 4nik - hPRTS subunit 10 + single-chain Fv
- 3t5x - hPRTS subunit Dss1 + PCI domain-containing protein 2
- 2dvw, 2dwz - mPRTS subunit 10 + hPRTS subunit 6B – mouse
- 3aji - mPRTS subunit 10 + subunit 4
- 2x5n - PRTS subunit RPN10 VWA domain – fission yeast
- 4ady - yPRTS subunit RPN2
- 3vlf - yPRTS subunit 7 + DNA mismatch repair protein
- 2mr3 - yPRTS subunit RPN9 – NMR
- 2mqw - yPRTS subunit RPN9 N terminal – NMR
- 2mri - yPRTS subunit RPN9 C terminal – NMR
- 4b0z - yPRTS subunit RPN12
- 2z4d - yPRTS subunit RPN13
- 3vl1 - yPRTS subunit RPN14 (mutant)
- 4o8x, 4o8y - yPRTS subunit RPN8 + RPN11
- 4ocl, 4ocm, 4ocn - yPRTS subunit RPN8 + RPN11 + nanobody
- 3t5v - yPRTS subunit SEM1 + nuclear mRNA export proteins SAC3 and THP1
- 2z59 - mPRTS subunit RPN13+ubiquitin
- 3txm, 3txn – PRTS subunit P42B – Drosophila melanogaster
- Proteasome 26S particle
ReferencesReferences