Proliferating Cell Nuclear Antigen: Difference between revisions
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<StructureSection load='4d2g' size='350' side='right' caption='Human proliferating cell nuclear antigen trimer (grey, green, pink) complex with p15 peptide (yellow, magenta) (PDB entry [[4d2g]])' scene=''> | |||
<StructureSection load='4d2g' size='350' side='right' caption='Human proliferating cell nuclear antigen complex with p15 peptide (yellow) (PDB entry [[4d2g]])' scene=''> | |||
== Function == | == Function == | ||
[[Proliferating Cell Nuclear Antigen]] (PCNA) acts as a DNA sliding clamp by encircling the DNA and linking it to the genome. It is a processivity factor for DNA polymerase (Dpo) δ in eukaryotic cells<ref>PMID:12829735</ref>. | [[Proliferating Cell Nuclear Antigen]] (PCNA) acts as a DNA sliding clamp by encircling the DNA and linking it to the genome. It is a processivity factor for DNA polymerase (Dpo) δ in eukaryotic cells<ref>PMID:12829735</ref>. | ||
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== Relevance == | == Relevance == | ||
PCNA is useful in the diagnosis of high-grade dysplasia<ref>PMID:8781908</ref>. | PCNA is useful in the diagnosis of high-grade dysplasia<ref>PMID:8781908</ref>. | ||
== Structural highlights == | |||
p15 regulates DNA replication and repair by binding to PCNA. PCNA-p15 peptide complex shows the peptide passes through the PCNA ring and has numerous interactions with it<ref>PMID:25762514</ref>. | |||
</StructureSection> | |||
== 3D Structures of Proliferating Cell Nuclear Antigen == | == 3D Structures of Proliferating Cell Nuclear Antigen == | ||
Revision as of 11:10, 12 July 2016
FunctionProliferating Cell Nuclear Antigen (PCNA) acts as a DNA sliding clamp by encircling the DNA and linking it to the genome. It is a processivity factor for DNA polymerase (Dpo) δ in eukaryotic cells[1]. RelevancePCNA is useful in the diagnosis of high-grade dysplasia[2]. Structural highlightsp15 regulates DNA replication and repair by binding to PCNA. PCNA-p15 peptide complex shows the peptide passes through the PCNA ring and has numerous interactions with it[3]. |
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3D Structures of Proliferating Cell Nuclear Antigen3D Structures of Proliferating Cell Nuclear Antigen
Updated on 12-July-2016
ReferencesReferences
- ↑ Maga G, Hubscher U. Proliferating cell nuclear antigen (PCNA): a dancer with many partners. J Cell Sci. 2003 Aug 1;116(Pt 15):3051-60. PMID:12829735 doi:http://dx.doi.org/10.1242/jcs.00653
- ↑ Kullmann F, Fadaie M, Gross V, Knuchel R, Bocker T, Steinbach P, Scholmerich J, Ruschoff J. Expression of proliferating cell nuclear antigen (PCNA) and Ki-67 in dysplasia in inflammatory bowel disease. Eur J Gastroenterol Hepatol. 1996 Apr;8(4):371-9. PMID:8781908
- ↑ De Biasio A, de Opakua AI, Mortuza GB, Molina R, Cordeiro TN, Castillo F, Villate M, Merino N, Delgado S, Gil-Carton D, Luque I, Diercks T, Bernado P, Montoya G, Blanco FJ. Structure of p15(PAF)-PCNA complex and implications for clamp sliding during DNA replication and repair. Nat Commun. 2015 Mar 12;6:6439. doi: 10.1038/ncomms7439. PMID:25762514 doi:http://dx.doi.org/10.1038/ncomms7439