Autophagy-related protein

Autophagy-related proteins (Atg) function in autophagosome formation from the pre-autophagosomal structure (PAS). The phagosomes perform protein degradation under starvation. Autophagy is the process of forming a vacuole around proteins or nucleic acids destined to be broken down. This vacuole is a double membrane enclosure called phagophore. Atgs have non-autophagic functions as well as they are involved in cell survival and apoptosis. So far 34 Atgs have been identified in yeast. Atg1, 6, 14 are involved in the formation of the phagophore. Atg3 catalyzes the conjugation of Atg8 and phosphatidylethanolamine. This conjugation is essential for autophagosome formation. Atg4, 5, 7, 10, 16 are involved in the maturation of the phagophore. Atg8 is structurally similar to ubiquitin. It is a targeting factor in cytoplasm-to-vacuole transport of proteins such as aminopeptidase and a-mannosidase. Microtubule-associated protein light chain 3 LC3 is a mammalian Atg8. Atg12 is involved in the elongation of the phagophore. Atg13, 17 are PAS scaffold proteins. Atg101 is believed to protect Atg13 from proteasomal degradation. Structural highlights in yeast Atg7 C-terminal domain.

spinqualitylabelsall models Yeast Atg7 C terminal (green) complex with Atg8 (magenta) and Zn+2 ion (grey) (PDB code 3vh3) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of autophagy-related protein3D Structures of autophagy-related protein

Updated on 13-December-2015

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• Autophagy-related protein 3

• • 2dyt – yAtg3 – yeast
    
• Autophagy-related protein 4

• • 2z0d, 2z0e, 2zzp – hAtg4B (mutant) + LC3 – human
    
  • 2p82 – hAtg4A
    
• Autophagy-related protein 5

• • 3vqi – KmAtg5 – Kluyveromyces marxianus
    
  • 4tq1 – hAtg5 + TECAIR peptide
    
• Autophagy-related protein 7

• • 3vh1, 3vh2 – yAtg7
    
  • 3ruj, 3t7f – yAtg7 N terminal
    
  • 3t7h, 4gsj – yAtg7 N terminal (mutant)
    
  • 3t7e – yAtg7 C terminal
    
• Autophagy-related protein 8

• • 2kq7 – yAtg8 - NMR
    
  • 2kwc – yAtg8 (mutant) - NMR
    
  • 3m95 – Atg8 – silk worm
    
• Autophagy-related protein 10

• • 4ebr – yAtg10
    
• Autophagy-related protein 12

• • 1wz3 – AtAtg12B – Arabidopsis thaliana
    
• Autophagy-related protein 16

• • 3a7o – yAtg16 coiled-coil domain
    
  • 3a7p – yAtg16 coiled-coil domain (mutant)
    
• Autophagy-related protein 19

• • 2kzb – yAtg19 a-mannosidase binding domain - NMR
    
• Autophagy-related protein 101

• • 4wzg – hAtg101
    
• Autophagy-related protein 1+13

• • 4p1n – KmAtg1 + KmAtg13
    
• Autophagy-related protein 3+5+12+16

• • 4naw – hAtg3 peptide + hAtg5 + hAtg12 + hAtg16-1 N terminal
    
• Autophagy-related protein 5+12+16

• • 4gdk, 4gdl – hAtg5 + hAtg12 + hAtg16-1 N terminal
    
  • 3w1s – yAtg5 + yAtg12 + yAtg16 N terminal
    
• Autophagy-related protein 5+16

• • 2dym, 2dyo – yAtg5 + yAtg16 N terminal
    
  • 4tq0 – hAtg5 + hAtg16-1 N terminal
    
• Autophagy-related protein 7+3

• • 3t7g – yAtg7 N terminal + yAtg3 peptide
    
  • 4gsl – yAtg7 + yAtg3 (mutant)
    
  • 3vx8 – AtAtg7 N terminal + AtAtg3
    
• Autophagy-related protein 7+8

• • 3vh3 – yAtg7 C terminal + yAtg8 (mutant)
    
  • 2li5 – yAtg7 peptide + yAtg8 (mutant)
    
  • 3rui – yAtg7 C terminal (mutant) + yAtg8
    
  • 3vh4 – yAtg7 C terminal + yAtg8 (mutant) + ATP
    
• Autophagy-related protein 7+10

• • 4gsk – yAtg7 (mutant) + yAtg10 (mutant)
    
• Autophagy-related protein 8+19

• • 2zpn – yAtg8 + yAtg19 peptide
    
• Autophagy-related protein 8+32

• • 3vxw – yAtg8 + yAtg32 peptide
    
• Autophagy-related protein 13+101

• • 4yk8 – Atg13 + Atg101 – fission yeast
    
• Autophagy-related protein 17+29+31

• • 4hpq – yAtg17 peptide + yAtg29 + yAtg31 (mutant)
    
• Autophagy-related protein 13+17+29+31

• • 4p1w – yAtg13 + yAtg17 peptide +