3vx8

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Crystal structure of Arabidopsis thaliana Atg7NTD-Atg3 complexCrystal structure of Arabidopsis thaliana Atg7NTD-Atg3 complex

Structural highlights

3vx8 is a 4 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 3.11Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ATG7_ARATH E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes. Involved in the senescence process.[1]

See Also

References

  1. ↑ Doelling JH, Walker JM, Friedman EM, Thompson AR, Vierstra RD. The APG8/12-activating enzyme APG7 is required for proper nutrient recycling and senescence in Arabidopsis thaliana. J Biol Chem. 2002 Sep 6;277(36):33105-14. Epub 2002 Jun 17. PMID:12070171 doi:http://dx.doi.org/10.1074/jbc.M204630200

3vx8, resolution 3.11Å

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OCA
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