Cluster of Differentiation CD38: Difference between revisions
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<StructureSection load='2i65' size='450' side='right' scene= caption='Human Cluster of Differentiation 38 (CD38) complex with NAD [[2i65]]'> | |||
<StructureSection load='2i65' size='450' side='right' scene= caption=' | |||
== Function == | == Function == | ||
Revision as of 12:55, 26 November 2015
FunctionCluster of Differentiation 38 (CD38), known also as ADP-ribosyl cyclase 1 (ADPRC1), catalyzes the synthesis and hydrolysis of cyclic ADP-ribose from NAD+ to ADP-ribose (ADPR). It is found on the surface of immune cells. It also functions in cell adhesion, signal transduction and Ca+2 signaling. ADP-ribosyl cyclase (ADPRC) is the Aplysia californica homolog of CD38. It catalyzes the synthesis and hydrolysis of cyclic ADP-ribose. It uses NAD+ as substrate and produces cyclic ADP-ribose (cADPR).[1] RelevanceCD38 is used as a marker for cell activation and for leukemia. |
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3D Structures of Cluster of Differentiation 383D Structures of Cluster of Differentiation 38
Updated on 26-November-2015
ReferencesReferences
- ↑ Liu Q, Kriksunov IA, Graeff R, Munshi C, Lee HC, Hao Q. Crystal structure of human CD38 extracellular domain. Structure. 2005 Sep;13(9):1331-9. PMID:16154090 doi:http://dx.doi.org/10.1016/j.str.2005.05.012