Aminoacyl tRNA Synthetase: Difference between revisions

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**[[1iq0]] – TtArgRS  - ''Thermus thermophilus''
**[[1iq0]] – TtArgRS  - ''Thermus thermophilus''


*Arg-RS + tRNA
*''Arg-RS + tRNA''


**[[2zuf]] - PhArgRS  + Arg-tRNA - ''Pyrococcus horikoshii''<br />
**[[2zuf]] - PhArgRS  + Arg-tRNA - ''Pyrococcus horikoshii''<br />
**[[1f7v]] - yArgRS  + Arg-tRNA
**[[1f7v]] - yArgRS  + Arg-tRNA


*Arg-RS ternary complex
*''Arg-RS ternary complex''


**[[1f7u]] – yArgRS  + Arg-tRNA + Arg<br />
**[[1f7u]] – yArgRS  + Arg-tRNA + Arg<br />
Line 59: Line 59:
**[[1li7]] - EcCysRS + Cys<br />
**[[1li7]] - EcCysRS + Cys<br />
**[[1u0b]] – EcCysRS + Cys-tRNA  
**[[1u0b]] – EcCysRS + Cys-tRNA  
}}
===Gln-RS===


[[1nyl]]– EcGlnRS<br />
*Gln-RS
[[2gls]], [[1lgr]] – StGlnRS – ''Salmonella typhimurium''<br />
 
[[2lgs]] – StGlnRS + Glu<br />
**[[1nyl]]– EcGlnRS<br />
[[1qrt]], [[ 1qru]], [[1qrs]] - EcGlnRS (mutant) + Gln-tRNA<br />
**[[2gls]], [[1lgr]] – StGlnRS – ''Salmonella typhimurium''<br />
[[1gtr]], [[ 1gts]], [[ 1gsg]] - EcGlnRS + Gln-tRNA<br />
**[[2lgs]] – StGlnRS + Glu<br />
[[1qtq]] - EcGlnRS + Gln-tRNA + Gln analog
**[1qrt]], [[1qru]], [[1qrs]] - EcGlnRS (mutant) + Gln-tRNA<br />
**[[1gtr]], [[1gts]], [[1gsg]] - EcGlnRS + Gln-tRNA<br />
**[[1qtq]] - EcGlnRS + Gln-tRNA + Gln analog


''Gln-RS ternary complex''
*''Gln-RS ternary complex''


[[1euq]], [[ 1euy]] – EcGlnRS + Gln-tRNA + Gln-SA<br />
**[[1euq]], [[ 1euy]] – EcGlnRS + Gln-tRNA + Gln-SA<br />
[[1exd]] - EcGlnRS + Gln-tRNA (mutant) + AMP
**[[1exd]] - EcGlnRS + Gln-tRNA (mutant) + AMP


===Glu-RS===
*Glu-RS


[[1gln]] – TtGluRS<br />
**[[1gln]] – TtGluRS<br />
[[2o5r]] - TmGluRS<br />
**[[2o5r]] - TmGluRS<br />
[[3aii]] – GluRS – ''Methanothermobacter thermautotrophicus''<br />
**[[3aii]] – GluRS – ''Methanothermobacter thermautotrophicus''<br />
[[2ja2]] – MtGluRS – ''Mycobacterium tuberculosis''<br />
**[[2ja2]] – MtGluRS – ''Mycobacterium tuberculosis''<br />
[[2zlz]] – EcGluRS<br />
**[[2zlz]] – EcGluRS<br />
[[2hz7]] – DrGluRS – ''Deinococcus radiodurans''<br />
**[[2hz7]] – DrGluRS – ''Deinococcus radiodurans''<br />
[[2hra]] – yGluRS N-terminal
**[[2hra]] – yGluRS N-terminal
   
   
''Glu-RS + small substrates or analogs''
*''Glu-RS + small substrates or analogs''


[[3afh]] - TmGluRS + Glu-AMP analog<br />
**[[3afh]] - TmGluRS + Glu-AMP analog<br />
[[2rd2]], [[ 2re8]] – EcGluRS (mutant) + Glu-SA<br />
**[[2rd2]], [[ 2re8]] – EcGluRS (mutant) + Glu-SA<br />
[[2cuz]] – TtGluRS + Glu<br />
**[[2cuz]] – TtGluRS + Glu<br />
[[1j09]] - TtGluRS + Glu + ATP<br />
**[[1j09]] - TtGluRS + Glu + ATP<br />
[[1n75]] - TtGluRS + ATP<br />
**[[1n75]] - TtGluRS + ATP<br />
[[2fco]] - GluRS residues 2-485 + Glu – ''Synechococcus elongatus''
**[[2fco]] - GluRS residues 2-485 + Glu – ''Synechococcus elongatus''


''Glu-RS + tRNA''
*''Glu-RS + tRNA''


[[1zjw]] – EcGluRS + Glu-tRNA
**[[1zjw]] – EcGluRS + Glu-tRNA


''Glu-RS ternary complex''
*''Glu-RS ternary complex''


[[3akz]], [[ 3al0]] – TmGluRS + tRNA + Glu-AMP analog – ''Thermotoga maritima''<br />
**[[3akz]], [[ 3al0]] – TmGluRS + tRNA + Glu-AMP analog – ''Thermotoga maritima''<br />
[[1o0b]], [[ 1o0c]] - EcGluRS + Glu-tRNA + Glu + AMP<br />[[2cv0]], [[ 1n77]] - TtGluRS + Glu + Glu-tRNA<br />
**[[1o0b]], [[ 1o0c]] - EcGluRS + Glu-tRNA + Glu + AMP<br />[[2cv0]], [[ 1n77]] - TtGluRS + Glu + Glu-tRNA<br />
[[1n78]] - TtGluRS + Glu-ol + Glu-tRNA<br />
**[[1n78]] - TtGluRS + Glu-ol + Glu-tRNA<br />
[[2cv1]] - TtGluRS + Glu-ol + ATP + Glu-tRNA<br />
**[[2cv1]] - TtGluRS + Glu-ol + ATP + Glu-tRNA<br />
[[2cv2]] - TtGluRS + Glu-SA + Glu-tRNA<br />
**[[2cv2]] - TtGluRS + Glu-SA + Glu-tRNA<br />
[[2hrk]], [[ 2hsm]] - yGluRS N-terminal + GU4 nucleic-binding protein 1
**[[2hrk]], [[ 2hsm]] - yGluRS N-terminal + GU4 nucleic-binding protein 1


===Ile-RS===
*Ile-RS


[[1ile]] - TtIleRS<br />
**[[1ile]] - TtIleRS<br />
[[1wny]], [[ 1udz]] – TtIleRS editing domain
**[[1wny]], [[ 1udz]] – TtIleRS editing domain


''Ile-RS + small substrates or analogs''<br />
*''Ile-RS + small substrates or analogs''<br />


[[1ue0]] - TtIleRS editing domain + Val<br />
**[[1ue0]] - TtIleRS editing domain + Val<br />
[[1wnz]] - TtIleS editing domain + Val-adenylate<br />
**[[1wnz]] - TtIleS editing domain + Val-adenylate<br />
[[1wk8]] - TtIleRS editing domain + Val-SA<br />
**[[1wk8]] - TtIleRS editing domain + Val-SA<br />
[[1jzq]] – TtIleS + Ile-adenylate analog<br />
**[[1jzq]] – TtIleS + Ile-adenylate analog<br />
[[1jzs]] – TtIleS + antibiotic
**[[1jzs]] – TtIleS + antibiotic


''Ile-RS ternary complex''<br />
*''Ile-RS ternary complex''<br />


[[1ffy]], [[ 1qu2]], [[ 1qu3]] - SaIleRS + Ile-tRNA + antibiotic - ''Staphylococcus aureus''
**[[1ffy]], [[ 1qu2]], [[ 1qu3]] - SaIleRS + Ile-tRNA + antibiotic - ''Staphylococcus aureus''


===Leu-RS===
*Leu-RS


[[3o0a]] – AaLeuRS hydrolytic domain – ''Aquifex aeolicus''<br />[[2wfd]] – hLeuRS editing domain – human<br />
**[[3o0a]] – AaLeuRS hydrolytic domain – ''Aquifex aeolicus''<br />[[2wfd]] – hLeuRS editing domain – human<br />
[[2wfe]] - CaLeuRS editing domain – ''Candida albicans''<br />
**[[2wfe]] - CaLeuRS editing domain – ''Candida albicans''<br />
[[2ajg]] - EcLeuRS editing domain<br />
**[[2ajg]] - EcLeuRS editing domain<br />
[[1wkb]] – PhLeuRS residues 1-810
**[[1wkb]] – PhLeuRS residues 1-810


''Leu-RS + small substrates or analogs''<br />
*''Leu-RS + small substrates or analogs''<br />


[[2wfg]] - CaLeuRS editing domain + benzoxaborole-AMP<br />
**[[2wfg]] - CaLeuRS editing domain + benzoxaborole-AMP<br />
[[2v0c]] – TtLeuRS + Leu-SA + benzoxaborole-AMP<br />
**[[2v0c]] – TtLeuRS + Leu-SA + benzoxaborole-AMP<br />
[[1h3n]] - TtLeuRS + Leu-SA<br />
**[[1h3n]] - TtLeuRS + Leu-SA<br />
[[1obc]], [[ 1obh]] – TtLeuRS + substrate analog<br />
**[[1obc]], [[1obh]] – TtLeuRS + substrate analog<br />
[[2ajh]], [[ 2aji]] - EcLeuRS editing domain + aa
**[[2ajh]], [[2aji]] - EcLeuRS editing domain + aa


''Leu-RS + tRNA''<br />
*''Leu-RS + tRNA''<br />


[[1wz2]] – PhLeuRS Leu-tRNA
**[[1wz2]] – PhLeuRS Leu-tRNA


''Leu-RS ternary complex''<br />
*''Leu-RS ternary complex''<br />


[[2v0g]] - TtLeuRS + Leu-tRNA + benzoxaborole-AMP<br />
**[[2bte]], [[ 2byt]] - TtLeuRS + Leu-tRNA + Leu
[[2bte]], [[ 2byt]] - TtLeuRS + Leu-tRNA + Leu


===Lys-RS===
*Lys-RS


[[1irx]] – PhLysRS<br />
**[[1irx]] – PhLysRS<br />
[[1bbw]] – EcLysRS<br />
**[[1bbw]] – EcLysRS<br />
[[1krs]], [[ 1krt]] – EcLysRS anticodon-binding domain – NMR<br />[[3dsq]] – DhLysRS – ''Desulfitobacterium hafniense''<br />
**[[1krs]], [[ 1krt]] – EcLysRS anticodon-binding domain – NMR<br />[[3dsq]] – DhLysRS – ''Desulfitobacterium hafniense''<br />
[[2e3c]] - MmLysRS catalytic domain - ''Methanosarcina mazei''<br />
**[[2e3c]] - MmLysRS catalytic domain - ''Methanosarcina mazei''<br />
[[3bju]] – hLysRS residues 70-579
**[[3bju]] – hLysRS residues 70-579


''Lys-RS + small substrates or analogs''<br />
*''Lys-RS + small substrates or analogs''<br />


[[3a74]] – GsLysRS + diadenosine tetraphosphate – ''Geobacillus stearothermophilus''<br />
**[[3a74]] – GsLysRS + diadenosine tetraphosphate – ''Geobacillus stearothermophilus''<br />
[[3e9h]], [[ 3e9i]] – BsLysRS + Lys-SA - ''Bacillus stearothermophilus''<br />
**[[3e9h]], [[3e9i]] – BsLysRS + Lys-SA - ''Bacillus stearothermophilus''<br />
[[2zin]] – MmLysRS catalytic domain + Boc-Lys + ATP analog<br />  
**[[2zin]] – MmLysRS catalytic domain + Boc-Lys + ATP analog<br />  
[[2zio]] - MmLysRS catalytic domain + Aloc-Lys-AMP + PNP<br />
**[[2zio]] - MmLysRS catalytic domain + Aloc-Lys-AMP + PNP<br />
[[2zcd]] - MmLysRS catalytic domain + AMPPNP<br />
**[[2zcd]] - MmLysRS catalytic domain + AMPPNP<br />
[[2zce]] - MmLysRS catalytic domain + pyrro-Lys + ATP analog<br />
**[[2zce]] - MmLysRS catalytic domain + pyrro-Lys + ATP analog<br />
[[2zim]] - MmLysRS residues 185-454+ pyrro-Lys-adenylate<br />  
**[[2zim]] - MmLysRS residues 185-454+ pyrro-Lys-adenylate<br />  
[[2q7e]] - MmLysRS C-terminal + ATP analog<br />
**[[2q7e]] - MmLysRS C-terminal + ATP analog<br />
[[2q7g]] - MmLysRS C-terminal+ pyrro-Lys analog+ ATP <br />
**[[2q7g]] - MmLysRS C-terminal+ pyrro-Lys analog+ ATP <br />
[[1bbu]], [[ 1e10]], [[ 1lyl]] – EcLysRS + Lys<br />
**[[1bbu]], [[1e10]], [[1lyl]] – EcLysRS + Lys<br />
[[1e1t]] - EcLysRS + Lys-adenylate<br />
**[[1e1t]] - EcLysRS + Lys-adenylate<br />
[[1e22]] - EcLysRS + Lys + AMPPCP<br />
**[[1e22]] - EcLysRS + Lys + AMPPCP<br />
[[1e24]] - EcLysRS + Lys + ATP
**[[1e24]] - EcLysRS + Lys + ATP


''Leu-RS + tRNA''<br />
*''Leu-RS + tRNA''<br />


[[2zni]], [[ 2znj]] – DhLysRS + tRNA
**[[2zni]], [[2znj]] – DhLysRS + tRNA


===Met-RS===
*Met-RS


[[1a8h]] – TtMetRS<br />
**[[1a8h]] – TtMetRS<br />
[[1med]], [[1mea]] – EcMetRS Zinc-binding domain - NMR<br />
**[[1med]], [[1mea]] – EcMetRS Zinc-binding domain - NMR<br />
[[1qqt]] - EcMetRS residues 2-552<br />
**[[1qqt]] - EcMetRS residues 2-552<br />
[[2x1l]] - MsMetRS residues 2-515 – ''Mycobacterium smegmatis''<br />
**[[2x1l]] - MsMetRS residues 2-515 – ''Mycobacterium smegmatis''<br />
[[3h97]] – EcMetRS residues 2-548 (mutant) <br />  
**[[3h97]] – EcMetRS residues 2-548 (mutant) <br />  
[[3h9c]] - EcMetRS residues 2-548<br />
**[[3h9c]] - EcMetRS residues 2-548<br />
[[2d54]], [[ 2d5b]] – TtMetRS (mutant) <br />
**[[2d54]], [[2d5b]] – TtMetRS (mutant) <br />
[[1woy]] – TtMetRS residues 1-500 (mutant) <br />
**[[1woy]] – TtMetRS residues 1-500 (mutant) <br />
[[2djv]] – hMetRS WHEP-TRS domain – NMR<br />
**[[2djv]] – hMetRS WHEP-TRS domain – NMR<br />
[[1pyb]] – AaMetRS β subunit<br />
**[[1pyb]] – AaMetRS β subunit<br />
[[1rqg]] – PaMetRS – ''Pyrococcus abyssi''<br />
**[[1rqg]] – PaMetRS – ''Pyrococcus abyssi''<br />
[[1mkh]] – PaMetRS C-terminal
**[[1mkh]] – PaMetRS C-terminal


''Met-RS + small substrates or analogs''<br />
*''Met-RS + small substrates or analogs''<br />


[[3kfl]] – LmMetRS residues 206-747+ Met-adenylate - ''Leishmania major''<br />
**[[3kfl]] – LmMetRS residues 206-747+ Met-adenylate - ''Leishmania major''<br />
[[2x1m]] - MsMetRS residues 2-515 + Met<br />
**[[2x1m]] - MsMetRS residues 2-515 + Met<br />
[[1p7p]], [[ 1pfu]], [[ 1pfv]], [[ 1pfw]] - EcMetRS residues 2-548 + Met<br />
**[[1p7p]], [[1pfu]], [[1pfv]], [[1pfw]] - EcMetRS residues 2-548 + Met<br />
[[1pfy]] - EcMetRS residues 1-551 + Met-SA<br />
**[[1pfy]] - EcMetRS residues 1-551 + Met-SA<br />
[[1f4l]] - EcMetRS residues 1-551 + Met<br />
**[[1f4l]] - EcMetRS residues 1-551 + Met<br />
[[1pg0]] - EcMetRS residues 1-551 + Met-adenylate<br />
**[[1pg0]] - EcMetRS residues 1-551 + Met-adenylate<br />
[[1pg2]] - EcMetRS residues 1-551 + Met + adenine<br />
**[[1pg2]] - EcMetRS residues 1-551 + Met + adenine<br />
[[3h99]] - EcMetRS residues 2-548 (mutant) + Met<br />
**[[3h99]] - EcMetRS residues 2-548 (mutant) + Met<br />
[[3h9b]] - EcMetRS residues 2-548 (mutant) + azidonorleucine<br />
**[[3h9b]] - EcMetRS residues 2-548 (mutant) + azidonorleucine<br />
[[4dlp]] - MetRS + SMet – ''Brucella melitensis''
**[[4dlp]] - MetRS + SMet – ''Brucella melitensis''


''Met-RS + tRNA''<br />
*''Met-RS + tRNA''<br />


[[2csx]] – AaMetRS + Met-tRNA
**[[2csx]] – AaMetRS + Met-tRNA


''Met-RS + tRNA''<br />
*''Met-RS + tRNA''<br />


[[2ct8]] - AaMetRS + Met-tRNA + Met-SA<br />
**[[2ct8]] - AaMetRS + Met-tRNA + Met-SA<br />
[[2dxi]] – TtMetRS + tRNA + ATP + Glu-ol
**[[2dxi]] – TtMetRS + tRNA + ATP + Glu-ol


[[2hsn]] - yMetRS N-terminal + GU4 nucleic-binding protein 1 N-terminal
**[[2hsn]] - yMetRS N-terminal + GU4 nucleic-binding protein 1 N-terminal


===Trp-RS===
*Trp-RS


[[1d2r]] - GsTrpRS<br />
**[[1d2r]] - GsTrpRS<br />
[[3prh]] – TrpRS (mutant) – ''Bacillus subtilis''<br />
**[[3prh]] – TrpRS (mutant) – ''Bacillus subtilis''<br />
[[3n9i]] – TrpRS – ''Yarsinia pestis''<br />
**[[3n9i]] – TrpRS – ''Yarsinia pestis''<br />
[[3m5w]] – CjTrpRS – ''Campylobacter jejuni''<br />
**[[3m5w]] – CjTrpRS – ''Campylobacter jejuni''<br />
[[3a04]] – ApTrpRS – ''Aeropyrum pernix''<br />
**[[3a04]] – ApTrpRS – ''Aeropyrum pernix''<br />
[[3hzr]] – EhTrpRS – ''Entamoeba histolytica'' <br />
**[[3hzr]] – EhTrpRS – ''Entamoeba histolytica'' <br />
[[3i05]] – TbTrpRS residues 3-389 – ''Trypanosoma brucei''<br />
**[[3i05]] – TbTrpRS residues 3-389 – ''Trypanosoma brucei''<br />
[[3hv0]] – TRrpS residues 206-593 – ''Cryptosporidium parvum''<br />
**[[3hv0]] – TRrpS residues 206-593 – ''Cryptosporidium parvum''<br />
[[3foc]] – GlTrpRS – ''Giardia lamblia''<br />
**[[3foc]] – GlTrpRS – ''Giardia lamblia''<br />
[[1o5t]] – hTrpRS catalytic fragment<br />
**[[1o5t]] – hTrpRS catalytic fragment<br />
[[1ulh]] – hTrpRS residues 35-424<br />
**[[1ulh]] – hTrpRS residues 35-424<br />
[[2el7]] – TtTrpRS<br />
**[[2el7]] – TtTrpRS<br />
[[2ip1]], [[3kt0]] – yTrpRS – yeast<br />
**[[2ip1]], [[3kt0]] – yTrpRS – yeast<br />
[[2yy5]] – TrpRS – ''Mycoplasma pneumoniae''<br />
**[[2yy5]] – TrpRS – ''Mycoplasma pneumoniae''<br />
[[2g36]] – TmTrpRS<br />
**[[2g36]] – TmTrpRS<br />
[[1bks]] – StTrpRS + pyridoxal phosphate
**[[1bks]] – StTrpRS + pyridoxal phosphate


''Trp-RS + small substrates or analogs''<br />
*''Trp-RS + small substrates or analogs''<br />


[[3a05]] – ApTrpRS + Trp<br />
**[[3a05]] – ApTrpRS + Trp<br />
[[3kt3]] – yTrpRS + Trp-adenylate<br />
**[[3kt3]] – yTrpRS + Trp-adenylate<br />
[[3kt6]], [[ 3kt8]] – yTrpRS + Trp<br />  
**[[3kt6]], [[3kt8]] – yTrpRS + Trp<br />  
[[3jxe]] – PhTrpRS + Trp-adenylate<br />
**[[3jxe]] – PhTrpRS + Trp-adenylate<br />
[[3fhj]], [[ 3fio]] – BsTrpRS + Trp + AMP + Pi<br />
**[[3fhj]], [[3fio]] – BsTrpRS + Trp + AMP + Pi<br />
[[2quh]] – hTrpRS + Trp<br />
**[[2quh]] – hTrpRS + Trp<br />
[[2qui]] - hTrpRS + Trp-amide + ATP<br />
**[[2qui]] - hTrpRS + Trp-amide + ATP<br />
[[2quj]] - hTrpRS + Trp-adenylate<br />
**[[2quj]] - hTrpRS + Trp-adenylate<br />
[[2quk]] – hTrpRS + ATP<br />
**[[2quk]] – hTrpRS + ATP<br />
[[2ov4]] – GsTrpRS + adenosine tetraphosphate<br />
**[[2ov4]] – GsTrpRS + adenosine tetraphosphate<br />
[[1i6k]], [[ 1i6l]], [[ 1i6m]] – GsTrpRS + Trp-adenylate<br />
**[[1i6k]], [[1i6l]], [[1i6m]] – GsTrpRS + Trp-adenylate<br />
[[1yid]], [[ 2a4m]] – DrTrpRS + ATP<br />
**[[1yid]], [[2a4m]] – DrTrpRS + ATP<br />
[[1yi8]], [[ 1yia]] – DrTrpRS + Trp<br />
**[[1yi8]], [[1yia]] – DrTrpRS + Trp<br />
[[1mau]] – GsTrpRS + Trp + ATP<br />
**[[1mau]] – GsTrpRS + Trp + ATP<br />
[[1maw]], [[ 1m83]] - GsTrpRS + ATP<br />
**[[1maw]], [[ 1m83]] - GsTrpRS + ATP<br />
[[1mb2]] - GsTrpRS + Trp <br />
**[[1mb2]] - GsTrpRS + Trp <br />
[[3tze]] - TrpRS + Trp - ''Encephalitozoon cuniculi''<br />
**[[3tze]] - TrpRS + Trp - ''Encephalitozoon cuniculi''<br />
[[3tzl]] - CjTrpRS + Trp + ADP<br />
**[[3tzl]] - CjTrpRS + Trp + ADP<br />
[[3sz3]] - TrpRS + Trp - ''Vibrio cholerae''<br />
**[[3sz3]] - TrpRS + Trp - ''Vibrio cholerae''<br />


''Trp-RS + tRNA''<br />
*''Trp-RS + tRNA''<br />


[[2azx]] – hTrpRS (mutant) + tRNA<br />
**[[2ake]], [[2dr2]] - hTrpRS + Trp-tRNA  
[[2ake]], [[ 2dr2]] - hTrpRS + Trp-tRNA  


===Tyr-RS===
*Tyr-RS


[[1tya]], [[ 1tyb]], [[ 1tyc]], [[ 1tyd]], [[ 2ts1]] – GsTyrRS<br />
**[[1tya]], [[ 1tyb]], [[ 1tyc]], [[ 1tyd]], [[ 2ts1]] – GsTyrRS<br />
[[3qe4]], [[ 3d6u]], [[ 3d6v]], [[ 2pxh]], [[ 2hgz]], [[ 1u7d]] – MjTyrRS – ''Methanocaldococcus jannaschii''<br />
**[[3qe4]], [[3d6u]], [[3d6v]], [[2pxh]], [[2hgz]], [[1u7d]] – MjTyrRS – ''Methanocaldococcus jannaschii''<br />
[[1u7x]], [[4hjr]], [[4hk4]]- MjTyrRS (mutant) <br />
**[[1u7x]], [[4hjr]], [[4hk4]]- MjTyrRS (mutant) <br />
[[2jan]] – MtTyrRS<br />
**[[2jan]] – MtTyrRS<br />
[[1y42]] - NcTyrRS  – ''Neurospora crassa''<br />
**[[1y42]] - NcTyrRS  – ''Neurospora crassa''<br />
[[2cya]] – ApTyrRS<br />
**[[2cya]] – ApTyrRS<br />
[[1n3l]] - hTyrRS residues 1-364<br />
**[[1n3l]] - hTyrRS residues 1-364<br />
[[1r6t]], [[ 1r6u]] – yTyrRS (mutant) <br />
**[[1r6t]], [[1r6u]] – yTyrRS (mutant) <br />
[[1jh3]] – GsTyrRS C-terminal – NMR<br />
**[[1jh3]] – GsTyrRS C-terminal – NMR<br />


''Tyr-RS + small substrates or analogs''<br />
*''Tyr-RS + small substrates or analogs''<br />


[[3ts1]] – GsTyrRS + Tyr-adenylate intermediate<br />
**[[3ts1]] – GsTyrRS + Tyr-adenylate intermediate<br />
[[4ts1]] – GsTyrRS + Tyr<br />
**[[4ts1]] – GsTyrRS + Tyr<br />
[[3p0h]], [[ 3p0i]], [[ 3p0j]] – LmTyrRS + inhibitor<br />  
**[[3p0h]], [[3p0i]], [[3p0j]] – LmTyrRS + inhibitor<br />  
[[3n2y]] – MjTyrRS + tetrazolyl phenylalanine<br />
**[[3n2y]] – MjTyrRS + tetrazolyl phenylalanine<br />
[[2zp1]] – MjTyrRS (mutant) + Tyr<br />
**[[2zp1]] – MjTyrRS (mutant) + Tyr<br />
[[1zh0]] - MjTyrRS (mutant) + naphthyl-Ala<br />
**[[1zh0]] - MjTyrRS (mutant) + naphthyl-Ala<br />
[[1zh6]] - MjTyrRS (mutant) + acetyl-Phe<br />
**[[1zh6]] - MjTyrRS (mutant) + acetyl-Phe<br />
[[2ag6]] - MjTyrRS (mutant) + bromo-Phe<br />
**[[2ag6]] - MjTyrRS (mutant) + bromo-Phe<br />
[[4hjx]] - MjTyrRS (mutant) + di-fluoro-Tyr<br />
**[[4hjx]] - MjTyrRS (mutant) + di-fluoro-Tyr<br />
[[2yxn]] – EcTyrRS residues 1-322 + azido-Tyr<br />
**[[2yxn]] – EcTyrRS residues 1-322 + azido-Tyr<br />
[[1vbm]] – EcTyrRS + Tyr-SA<br />
**[[1vbm]] – EcTyrRS + Tyr-SA<br />
[[1vbn]] – EcTyrRS (mutant) + Tyr-SA<br />
**[[1vbn]] – EcTyrRS (mutant) + Tyr-SA<br />
[[1wq3]], [[ 1wq4]] - EcTyrRS (mutant) + Tyr<br />
**[[1wq3]], [[1wq4]] - EcTyrRS (mutant) + Tyr<br />
[[1x8x]] – EcTyrRS + Tyr<br />[[2pid]] – hTyrRS residues 28-375 + Tyr-SA<br />
**[[1x8x]] – EcTyrRS + Tyr<br />
[[2j5b]] – TyrRS residues 2-346 + Tyr-ol – ''Acanthamoeba polyphaga'' minivirus<br />
**[[2pid]] – hTyrRS residues 28-375 + Tyr-SA<br />
[[2dlc]] – yTyrRS + tRNA + Tyr-SA<br />
**[[2j5b]] – TyrRS residues 2-346 + Tyr-ol – ''Acanthamoeba polyphaga'' minivirus<br />
[[2cyb]] – AfTyrRS + Tyr - ''Archaeoglobus fulgidus''<br />
**[[2dlc]] – yTyrRS + tRNA + Tyr-SA<br />
[[2cyc]] – PhTyrRS + Tyr<br />
**[[2cyb]] – AfTyrRS + Tyr - ''Archaeoglobus fulgidus''<br />
[[1q11]] – hTyrRS residues 1-364 + Tyr-ol<br />
**[[2cyc]] – PhTyrRS + Tyr<br />
[[1h3e]] - TtTyrRS + Tyr-tRNA + Tyr-ol + ATP<br />
**[[1q11]] – hTyrRS residues 1-364 + Tyr-ol<br />
[[1h3f]] - TtTyrRS + Tyr-ol<br />
**[[1h3e]] - TtTyrRS + Tyr-tRNA + Tyr-ol + ATP<br />
[[1jh3]] – GsTyrRS C-terminal – NMR<br />
**[[1h3f]] - TtTyrRS + Tyr-ol<br />
[[1jii]], [[ 1jij]], [[1jil]], [[1jik]] – SaTyrRS + inhibitor  
**[[1jh3]] – GsTyrRS C-terminal – NMR<br />
**[[1jii]], [[ 1jij]], [[1jil]], [[1jik]] – SaTyrRS + inhibitor  


''Tyr-RS + tRNA''<br />
*''Tyr-RS + tRNA''<br />


[[1j1u]] – MjTyrRS + Tyr-tRNA
**[[1j1u]] – MjTyrRS + Tyr-tRNA


[[2rkj]] – NcTyrRS + RNA  
**[[2rkj]] – NcTyrRS + RNA  


===Val-RS===
*Val-RS


[[1iyw]] - TtValRS<br />
**[[1iyw]] - TtValRS<br />
[[1wk9]], [[ 1wka]] – TtValRS CP1 domain  
**[[1wk9]], [[ 1wka]] – TtValRS CP1 domain  


''Val-RS ternary complex''<br />
*''Val-RS ternary complex''<br />


[[1ivs]] – TtValRS + Val-SA + Val-tRNA<br />
**[[1ivs]] – TtValRS + Val-SA + Val-tRNA<br />
[[1gax]] - TtValRS + Val-adenylate analog + Val-tRNA
**[[1gax]] - TtValRS + Val-adenylate analog + Val-tRNA


===Class II aaRS===
*'''Class II aaRS'''


===Ala-RS===
*Ala-RS


[[3g98]] – AaAlaRS residues 758-867<br />
**[[3g98]] – AaAlaRS residues 758-867<br />
[[1riq]] - AaAlaRS catalytic fragment<br />
**[[1riq]] - AaAlaRS catalytic fragment<br />
[[2zze]], [[ 2zzf]], [[ 1wnu]], [[ 1wxo]], [[ 1v4p]] – PhAlaRS<br />
**[[2zze]], [[ 2zzf]], [[ 1wnu]], [[ 1wxo]], [[ 1v4p]] – PhAlaRS<br />
[[2zvf]] – AfAlaRS C-terminal
**[[2zvf]] – AfAlaRS C-terminal


''Ala-RS + small substrates or analogs''<br />
*''Ala-RS + small substrates or analogs''<br />


[[3hxu]], [[ 3hxv]], [[ 3hxw]] – EcAlaRS catalytic fragment + aa-adenylate <br />
**[[3hxu]], [[3hxv]], [[3hxw]] – EcAlaRS catalytic fragment + aa-adenylate <br />
[[3hxz]], [[ 3hy0]], [[ 3hy1]] - EcAlaRS catalytic fragment (mutant) + aa-adenylate<br />
**[[3hxz]], [[3hy0]], [[3hy1]] - EcAlaRS catalytic fragment (mutant) + aa-adenylate<br />
[[3hxx]] - EcAlaRS catalytic fragment + AMPPCP<br />
**[[3hxx]] - EcAlaRS catalytic fragment + AMPPCP<br />
[[3hxy]] - EcAlaRS catalytic fragment + AMPPCP + Ala-AMP + PCP<br />
**[[3hxy]] - EcAlaRS catalytic fragment + AMPPCP + Ala-AMP + PCP<br />
[[3htz]] - AaAlaRS residues 2-454 + Ser<br />
**[[3htz]] - AaAlaRS residues 2-454 + Ser<br />
[[1yfr]] – AaAlaRS + ATP<br />
**[[1yfr]] – AaAlaRS + ATP<br />
[[1yfs]]  – AaAlaRS + Ala<br />
**[[1yfs]]  – AaAlaRS + Ala<br />
[[1yft]], [[ 1ygb]] - AaAlaRS catalytic fragment + aa<br />
**[[1yft]], [[1ygb]] - AaAlaRS catalytic fragment + aa<br />
[[2zzg]] - PhAlaRS + Ala-SA<br />
**[[2zzg]] - PhAlaRS + Ala-SA<br /
[[2ztg]] – AfAlaRS + Ala-SA<br />  
**[[2ztg]] – AfAlaRS + Ala-SA<br />  


===Asp-RS===
*Asp-RS


[[3nen]], [[ 1b8a]] – TkAspRS - ''Thermococcus kodakarensis''<br />  
**[[3nen]], [[1b8a]] – TkAspRS - ''Thermococcus kodakarensis''<br />  
[[3i7f]] – EhAspRS<br />
**[[3i7f]] – EhAspRS<br />
[[1wyd]]– AspRS – ''Sulfolobus tokodaii''<br />
**[[1wyd]] – AspRS – ''Sulfolobus tokodaii''<br />
[[1eov]] - yAspRS<br />
**[[1eov]] - yAspRS<br />
[[1n9w]], [[ 1l0w]], [[ 1g51]] – TtAspRS<br />
[[1n9w]], [[1l0w]], [[1g51]] – TtAspRS<br />
[[1eqr]] – EcAspRS
**[[1eqr]] – EcAspRS


''Asp-RS + small substrates or analogs''<br />
*''Asp-RS + small substrates or analogs''<br />


[[3nel]] – TkAspRS + Asp <br />
**[[3nel]] – TkAspRS + Asp <br />
[[3nem]] - TkAspRS + Asp-adenylate
**[[3nem]] - TkAspRS + Asp-adenylate


''Asp-RS + tRNA''<br />
*''Asp-RS + tRNA''<br />


[[3kfu]], [[ 1efw]] – TtAspRS + tRNA <br />
**[[3kfu]], [[1efw]] – TtAspRS + tRNA <br />
[[1asy]], [[ 1asz]] – yAspRS + Asp-tRNA
**[[1asy]], [[1asz]] – yAspRS + Asp-tRNA


''Asp-RS ternary complex''<br />
*''Asp-RS ternary complex''<br />


[[1il2]], [[ 1c0a]] – EcAspRS + Asp-tRNA + Asp-adenylate
**[[1il2]], [[1c0a]] – EcAspRS + Asp-tRNA + Asp-adenylate


===Asn-RS===
*Asn-RS


[[1x56]] - PhAsnRS <br />
**[[1x56]] - PhAsnRS <br />
[[2kqr]] – BmAsnRS N-terminal – NMR – ''Brugia malayi''
**[[2kqr]] – BmAsnRS N-terminal – NMR – ''Brugia malayi''


''Asn-RS + small substrates or analogs''<br />
*''Asn-RS + small substrates or analogs''<br />


[[2xti]] – BmAsnRS catalytic fragment + Asn-adenine analog<br />  
**[[2xti]] – BmAsnRS catalytic fragment + Asn-adenine analog<br />  
[[2xgt]] - BmAsnRS catalytic fragment + Asn-SA<br />
**[[2xgt]] - BmAsnRS catalytic fragment + Asn-SA<br />
[[1x54]] – PhAsnRS + Asn-adenylate<br />
**[[1x54]] – PhAsnRS + Asn-adenylate<br />
[[1x55]] - PhAsnRS + Asn-SA<br />
**[[1x55]] - PhAsnRS + Asn-SA<br />
[[11as]] – EcAsnRS + Asn<br />
**[[11as]] – EcAsnRS + Asn<br />
[[12as]] - EcAsnRS + Asn + AMP
**[[12as]] - EcAsnRS + Asn + AMP


===Gly-RS===
*Gly-RS


[[1ati]] – TtGlyRS<br />
**[[1ati]] – TtGlyRS<br />
[[2q5h]] – hGlyRS residues 55-739<br />
**[[2q5h]] – hGlyRS residues 55-739<br />
[[2q5i]] - hGlyRS residues 55-739 (mutant) <br />
**[[2q5i]] - hGlyRS residues 55-739 (mutant) <br />
[[2pme]] – hGlyRS<br />
**[[2pme]] – hGlyRS<br />
[[2pmf]] – hGlyRS (mutant) <br />
**[[2pmf]] – hGlyRS (mutant) <br />
[[1j5w]] – TmGlyRS α chain
**[[1j5w]] – TmGlyRS α chain


''Gly-RS + small substrates or analogs''<br />
*''Gly-RS + small substrates or analogs''<br />


[[2zt5]], [[ 2zxf]] – hGlyRS residues 55-739 + bis-adenosine tetraphosphate<br />  
**[[2zt5]], [[ 2zxf]] – hGlyRS residues 55-739 + bis-adenosine tetraphosphate<br />  
[[2zt6]] - hGlyRS residues 55-739 + AMPCPP<br />
**[[2zt6]] - hGlyRS residues 55-739 + AMPCPP<br />
[[2zt7]] - hGlyRS residues 55-739 + Gly + ATP<br />
**[[2zt7]] - hGlyRS residues 55-739 + Gly + ATP<br />
[[2zt8]] - hGlyRS residues 55-739 + Gly-AMP analog<br />
**[[2zt8]] - hGlyRS residues 55-739 + Gly-AMP analog<br />
[[1b76]] – TtGlyRS + ATP<br />
**[[1b76]] – TtGlyRS + ATP<br />
[[1ggm]] – TtGlyRS + Gly-adenylate
**[[1ggm]] – TtGlyRS + Gly-adenylate


===His-RS===
*His-RS


[[1htt]] - EcHisRS<br />
**[[3net]] – HisRS – Nostoc<br />
[[3net]] – HisRS – Nostoc<br />
**[[1h4v]] – TtHisRS<br />
[[1h4v]] – TtHisRS<br />
**[[1qe0]] – SaHisRS<br />
[[1qe0]] – SaHisRS<br />
**[[3hri]] – TbHisRS<br />
[[3hri]] – TbHisRS<br />
**[[1x59]] – hHisRS WHEP-TRS domain - NMR
[[1wu7]] – HisRS – ''Thermoplasma acidophilum''<br />
[[1x59]] – hHisRS WHEP-TRS domain - NMR


''His-RS + small substrates or analogs''<br />
*''His-RS + small substrates or analogs''<br />


[[3lc0]] – HisRS residues 45-478 + His – ''Trypanosoma cruzi''<br />
**[[3lc0]] – HisRS residues 45-478 + His – ''Trypanosoma cruzi''<br />
[[1adj]] – TtHisRS + His <br />
**[[1adj]] – TtHisRS + His <br />
[[3hrk]] - TbHisRS + His-adenylate<br />
**[[3hrk]] - TbHisRS + His-adenylate<br />
[[2el9]] - EcHisRS + His-SA<br />
**[[2el9]] - EcHisRS + His-SA<br />
[[1kmm]], [[ 1ady]] - EcHisRS + His-adenylate<br />
**[[1kmm]], [[1ady]] - EcHisRS + His-adenylate<br />
[[1kmn]] - EcHisRS + His-ol + ATP  
**[[1kmn]] - EcHisRS + His-ol + ATP  


===Phe-RS===
*Phe-RS


[[1pys]] – TtPheRS<br />
**[[1pys]] – TtPheRS<br />
[[3l4g]], [[ 3cmq]] – hPheRS<br />
**[[3l4g]], [[ 3cmq]] – hPheRS<br />
[[2cxi]] – PhPheRS β chain N-terminal<br />[[3ica]] – PheRS β chain – ''Porphyromonas gingivalis''
**[[2cxi]] – PhPheRS β chain N-terminal<br />[[3ica]] – PheRS β chain – ''Porphyromonas gingivalis''
   
   
''Phe-RS + small substrates or analogs''<br />
*''Phe-RS + small substrates or analogs''<br />


[[3pco]] – EcPheRS + phenylalanine+ AMP<br />  
**[[3pco]] – EcPheRS + phenylalanine+ AMP<br />  
[[3hfz]], [[ 2amc]] – TtPheRS α+β chains + Tyr<br />
**[[3hfz]], [[2amc]] – TtPheRS α+β chains + Tyr<br />
[[2akw]], [[ 1b70]] - TtPheRS α+β chains + Phe<br />
**[[2akw]], [[1b70]] - TtPheRS α+β chains + Phe<br />
[[1jjc]], [[ 1b7y]] - TtPheRS α+β chains + Phe-adenylate<br />
**[[1jjc]], [[1b7y]] - TtPheRS α+β chains + Phe-adenylate<br />
[[2aly]] - TtPheRS α+β chains + Phe-SA<br />
**[[2aly]] - TtPheRS α+β chains + Phe-SA<br />
[[2rhq]], [[ 2rhs]] – PheRS α+β chains (mutant) + inhibitor – ''Staphylococcus haemolyticus''
**[[2rhq]], [[2rhs]] – PheRS α+β chains (mutant) + inhibitor – ''Staphylococcus haemolyticus''


''Phe-RS + tRNA''<br />
*''Phe-RS + tRNA''<br />


[[1eiy]] - TtPheRS α+β chains + Phe-tRNA  
**[[1eiy]] - TtPheRS α+β chains + Phe-tRNA  


''Phe-RS ternary complex''
*''Phe-RS ternary complex''


[[2iy5]] - TtPheRS α+β chains + Phe-ol + Phe-tRNA
**[[2iy5]] - TtPheRS α+β chains + Phe-ol + Phe-tRNA


===Pro-RS===
*Pro-RS


[[1hc7]] – TtProRS<br />
**[[1hc7]] – TtProRS<br />
[[2i4l]] – RpProRS – ''Rhodopseudomonas palustris''<br />
**[[2i4l]] – RpProRS – ''Rhodopseudomonas palustris''<br />
[[1nj2]] - MtProRS – ''Methanothermobacter thermautotrophicus''<br />
**[[1nj2]] - MtProRS – ''Methanothermobacter thermautotrophicus''<br />
[[1nj8]] – MjProRS
**[[1nj8]] – MjProRS


''Pro-RS + small substrates or analogs''<br />
*''Pro-RS + small substrates or analogs''<br />


[[3ial]] – GlProRS residues 34-542 + Pro-adenylate<br />
**[[3ial]] – GlProRS residues 34-542 + Pro-adenylate<br />
[[2i4m]], [[ 2i4n]] – RpProRS + aa-SA<br />
**[[2i4m]], [[2i4n]] – RpProRS + aa-SA<br />
[[2i4o]] – RpProRS + ATP<br />
**[[2i4o]] – RpProRS + ATP<br />
[[2j3l]] – EfProRS + Pro-SA – ''Enterococcus faecalis''<br />
**[[2j3l]] – EfProRS + Pro-SA – ''Enterococcus faecalis''<br />
[[2j3m]] – EfProRS + Pro-ol + ATP<br />
**[[2j3m]] – EfProRS + Pro-ol + ATP<br />
[[1nj1]], [[ 1nj5]], [[ 1nj6]] – MtProRS + aa-SA<br />
**[[1nj1]], [[1nj5]], [[1nj6]] – MtProRS + aa-SA<br />
[[1h4t]] - TtProRS + Pro
**[[1h4t]] - TtProRS + Pro


''Pro-RS ternary complex''<br />
*''Pro-RS ternary complex''<br />


[[1h4q]] - TtProRS + Pro-tRNA + Pro-ol<br />
**[[1h4q]] - TtProRS + Pro-tRNA + Pro-ol<br />
[[1h4s]] - TtProRS + Pro-tRNA + Pro-SA<br />
**[[1h4s]] - TtProRS + Pro-tRNA + Pro-SA<br />


===Ser-RS===
*Ser-RS


[[3lsq]] – TbSerRS<br />  
**[[3lsq]] – TbSerRS<br />  
[[1sry]] - TtSerRS<br />
**[[1sry]] - TtSerRS<br />
[[3err]] – TtSerRS/dynein heavy chain<br />
**[[3err]] – TtSerRS/dynein heavy chain<br />
[[2zr3]] – PhSerRS<br />
**[[2zr3]] – PhSerRS<br />
[[2dq3]] – AaSerRS<br />
**[[2dq3]] – AaSerRS<br />
[[2du7]] – MjSerRS<br />
**[[2du7]] – MjSerRS<br />
[[2odr]] – SerRS – ''Methanococcus maripaludis''<br />
**[[2odr]] – SerRS – ''Methanococcus maripaludis''<br />
[[2cim]] – MbSerRS – ''Methanosarcina barkeri''<br />
**[[2cim]] – MbSerRS – ''Methanosarcina barkeri''<br />
[[1wle]] – SerRS – bovine
**[[1wle]] – SerRS – bovine


''Ser-RS + small substrates or analogs''<br />
*''Ser-RS + small substrates or analogs''<br />


[[2zr2]] – PhSerRS + ATP<br />
**[[2zr2]] – PhSerRS + ATP<br />
[[2dq0]] – PhSerRS + Ser-SA<br />
**[[2cj9]] – MbSerRS + Ser-SA<br />
[[2cj9]] – MbSerRS + Ser-SA<br />
**[[2cjb]] – MbSerRS + Ser<br />
[[2cjb]] – MbSerRS + Ser<br />
**[[2cja]] – MbSerRS + ATP<br />
[[2cja]] – MbSerRS + ATP<br />
**[[1ses]], [[1set]] – TtSerRS + Ser-adenylate analog<br />
[[1ses]], [[ 1set]] – TtSerRS + Ser-adenylate analog<br />
**[[3lss]] – TbSerRS + ATP
[[3lss]] – TbSerRS + ATP


''Ser-RS + tRNA''<br />
*''Ser-RS + tRNA''<br />


[[1ser]] – TtSerRS + Ser-tRNA<br />
**[[1ser]] – TtSerRS + Ser-tRNA<br />
[[2du4]] - AfSerRS + Cys-tRNA
**[[2du4]] - AfSerRS + Cys-tRNA


''Ser-RS ternary complex''<br />
*''Ser-RS ternary complex''<br />


[[2du3]] – AfSerRS + Cys-tRNA + phosphoserine<br />
**[[2du3]] – AfSerRS + Cys-tRNA + phosphoserine<br />
[[2du5]], [[ 2du6]] - AfSerRS (mutant) + Cys-tRNA + phosphoserine
**[[2du5]], [[2du6]] - AfSerRS (mutant) + Cys-tRNA + phosphoserine


===Thr-RS===
*Thr-RS


[[1y2q]] - PaThrRS editing domain<br />
**[[1y2q]] - PaThrRS editing domain<br />
[[1wwt]] – hThrRS TGS domain – NMR<br />
**[[1wwt]] – hThrRS TGS domain – NMR<br />
[[1tje]] - EcThrRS editing domain
**[[1tje]] - EcThrRS editing domain


''Thr-RS + small substrates or analogs''<br />
*''Thr-RS + small substrates or analogs''<br />


[[3pd2]], [[ 3pd3]], [[ 3pd4]], [[ 3pd5]] – PaThrRS editing domain + aa-aminoadenosine<br />  
**[[3pd2]], [[3pd3]], [[3pd4]], [[3pd5]] – PaThrRS editing domain + aa-aminoadenosine<br />  
[[2hkz]] – PaThrRS editing domain + Ser<br />
**[[2hkz]] – PaThrRS editing domain + Ser<br />
[[2hl0]], [[ 2hl1]] - PaThrRS editing domain + Ser-adenylate<br />
**[[2hl0]], [[2hl1]] - PaThrRS editing domain + Ser-adenylate<br />
[[2hl2]] - PaThrRS editing domain + Ser-SA<br />
**[[2hl2]] - PaThrRS editing domain + Ser-SA<br />
[[1tke]] - EcThrRS editing domain + Ser<br />
**[[1tke]] - EcThrRS editing domain + Ser<br />
[[1tkg]] - EcThrRS editing domain + Ser-SA<br />
**[[1tkg]] - EcThrRS editing domain + Ser-SA<br />
[[1tky]] - EcThrRS editing domain + Ser-adenylate<br />
**[[1tky]] - EcThrRS editing domain + Ser-adenylate<br />
[[1fyf]], [[ 1evl]] - EcThrRS catalytic and anticodon-binding domains + aa-SA<br />
**[[1fyf]], [[1evl]] - EcThrRS catalytic and anticodon-binding domains + aa-SA<br />
[[1evk]] - EcThrRS catalytic and anticodon-binding domains + Thr<br />
**[[1evk]] - EcThrRS catalytic and anticodon-binding domains + Thr<br />
[[1nyq]] – SaThrRS + Thr-SA<br />  
**[[1nyq]] – SaThrRS + Thr-SA<br />  
[[1nyr]] – SaThrRS + ATP
**[[1nyr]] – SaThrRS + ATP


''Thr-RS + tRNA''<br />
*''Thr-RS + tRNA''<br />


[[1qf6]] – EcThrRS + Thr-tRNA<br />
**[[1qf6]] – EcThrRS + Thr-tRNA<br />
[[1kog]] – EcThrRS catalytic and anticodon-binding domains + mRNA
**[[1kog]] – EcThrRS catalytic and anticodon-binding domains + mRNA


'''Multifunctional RS'''
*Multifunctional RS
 
[[1fyj]] – hRS - NMR


**[[1fyj]] – hRS - NMR
}}


[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 14:57, 16 November 2014

File:3l4g.png
Crystal Structure of Aminoacyl tRNA synthetase 3l4g

Template:STRUCTURE 1f7v














Aminoacyl tRNA synthetase (aaRS) catalyzes the esterification of a specific amino acid to its cognate tRNA to form an aminoacyl-tRNA. The amino acid is transferred by the ribosome from the aminoacylated-tRNA onto a growing polypeptide chain. Class I of aaRS is a monomer or dimer, it has 2 highly conserved sequence motifs and it aminoacylates at the 2’-OH of an adenosine nucleotide. Class II of aaRS is a dimer or tetramer, it has 3 highly conserved sequence motifs and it aminoacylates at the 3’-OH of an adenosine nucleotide. CP1 domain of RS edits a mischarged aa-tRNA. Some of the crystal structures are complexes of the RS with their reactant analog: amino acid-sulfamoyl adenine (aa-SA).


3D Structures of Aminoacyl tRNA synthetase3D Structures of Aminoacyl tRNA synthetase

Updated on 16-November-2014

  • Glu-RS + small substrates or analogs
    • 3afh - TmGluRS + Glu-AMP analog
    • 2rd2, 2re8 – EcGluRS (mutant) + Glu-SA
    • 2cuz – TtGluRS + Glu
    • 1j09 - TtGluRS + Glu + ATP
    • 1n75 - TtGluRS + ATP
    • 2fco - GluRS residues 2-485 + Glu – Synechococcus elongatus
  • Glu-RS + tRNA
    • 1zjw – EcGluRS + Glu-tRNA
  • Glu-RS ternary complex
    • 3akz, 3al0 – TmGluRS + tRNA + Glu-AMP analog – Thermotoga maritima
    • 1o0b, 1o0c - EcGluRS + Glu-tRNA + Glu + AMP
      2cv0, 1n77 - TtGluRS + Glu + Glu-tRNA
    • 1n78 - TtGluRS + Glu-ol + Glu-tRNA
    • 2cv1 - TtGluRS + Glu-ol + ATP + Glu-tRNA
    • 2cv2 - TtGluRS + Glu-SA + Glu-tRNA
    • 2hrk, 2hsm - yGluRS N-terminal + GU4 nucleic-binding protein 1
  • Ile-RS
  • Ile-RS + small substrates or analogs
    • 1ue0 - TtIleRS editing domain + Val
    • 1wnz - TtIleS editing domain + Val-adenylate
    • 1wk8 - TtIleRS editing domain + Val-SA
    • 1jzq – TtIleS + Ile-adenylate analog
    • 1jzs – TtIleS + antibiotic
  • Ile-RS ternary complex
    • 1ffy, 1qu2, 1qu3 - SaIleRS + Ile-tRNA + antibiotic - Staphylococcus aureus
  • Leu-RS
    • 3o0a – AaLeuRS hydrolytic domain – Aquifex aeolicus
      2wfd – hLeuRS editing domain – human
    • 2wfe - CaLeuRS editing domain – Candida albicans
    • 2ajg - EcLeuRS editing domain
    • 1wkb – PhLeuRS residues 1-810
  • Leu-RS + small substrates or analogs
    • 2wfg - CaLeuRS editing domain + benzoxaborole-AMP
    • 2v0c – TtLeuRS + Leu-SA + benzoxaborole-AMP
    • 1h3n - TtLeuRS + Leu-SA
    • 1obc, 1obh – TtLeuRS + substrate analog
    • 2ajh, 2aji - EcLeuRS editing domain + aa
  • Leu-RS + tRNA
    • 1wz2 – PhLeuRS Leu-tRNA
  • Leu-RS ternary complex
  • Lys-RS
    • 1irx – PhLysRS
    • 1bbw – EcLysRS
    • 1krs, 1krt – EcLysRS anticodon-binding domain – NMR
      3dsq – DhLysRS – Desulfitobacterium hafniense
    • 2e3c - MmLysRS catalytic domain - Methanosarcina mazei
    • 3bju – hLysRS residues 70-579
  • Lys-RS + small substrates or analogs
    • 3a74 – GsLysRS + diadenosine tetraphosphate – Geobacillus stearothermophilus
    • 3e9h, 3e9i – BsLysRS + Lys-SA - Bacillus stearothermophilus
    • 2zin – MmLysRS catalytic domain + Boc-Lys + ATP analog
    • 2zio - MmLysRS catalytic domain + Aloc-Lys-AMP + PNP
    • 2zcd - MmLysRS catalytic domain + AMPPNP
    • 2zce - MmLysRS catalytic domain + pyrro-Lys + ATP analog
    • 2zim - MmLysRS residues 185-454+ pyrro-Lys-adenylate
    • 2q7e - MmLysRS C-terminal + ATP analog
    • 2q7g - MmLysRS C-terminal+ pyrro-Lys analog+ ATP
    • 1bbu, 1e10, 1lyl – EcLysRS + Lys
    • 1e1t - EcLysRS + Lys-adenylate
    • 1e22 - EcLysRS + Lys + AMPPCP
    • 1e24 - EcLysRS + Lys + ATP
  • Leu-RS + tRNA
  • Met-RS
    • 1a8h – TtMetRS
    • 1med, 1mea – EcMetRS Zinc-binding domain - NMR
    • 1qqt - EcMetRS residues 2-552
    • 2x1l - MsMetRS residues 2-515 – Mycobacterium smegmatis
    • 3h97 – EcMetRS residues 2-548 (mutant)
    • 3h9c - EcMetRS residues 2-548
    • 2d54, 2d5b – TtMetRS (mutant)
    • 1woy – TtMetRS residues 1-500 (mutant)
    • 2djv – hMetRS WHEP-TRS domain – NMR
    • 1pyb – AaMetRS β subunit
    • 1rqg – PaMetRS – Pyrococcus abyssi
    • 1mkh – PaMetRS C-terminal
  • Met-RS + small substrates or analogs
    • 3kfl – LmMetRS residues 206-747+ Met-adenylate - Leishmania major
    • 2x1m - MsMetRS residues 2-515 + Met
    • 1p7p, 1pfu, 1pfv, 1pfw - EcMetRS residues 2-548 + Met
    • 1pfy - EcMetRS residues 1-551 + Met-SA
    • 1f4l - EcMetRS residues 1-551 + Met
    • 1pg0 - EcMetRS residues 1-551 + Met-adenylate
    • 1pg2 - EcMetRS residues 1-551 + Met + adenine
    • 3h99 - EcMetRS residues 2-548 (mutant) + Met
    • 3h9b - EcMetRS residues 2-548 (mutant) + azidonorleucine
    • 4dlp - MetRS + SMet – Brucella melitensis
  • Met-RS + tRNA
    • 2csx – AaMetRS + Met-tRNA
  • Met-RS + tRNA
    • 2ct8 - AaMetRS + Met-tRNA + Met-SA
    • 2dxi – TtMetRS + tRNA + ATP + Glu-ol
    • 2hsn - yMetRS N-terminal + GU4 nucleic-binding protein 1 N-terminal
  • Trp-RS
    • 1d2r - GsTrpRS
    • 3prh – TrpRS (mutant) – Bacillus subtilis
    • 3n9i – TrpRS – Yarsinia pestis
    • 3m5w – CjTrpRS – Campylobacter jejuni
    • 3a04 – ApTrpRS – Aeropyrum pernix
    • 3hzr – EhTrpRS – Entamoeba histolytica
    • 3i05 – TbTrpRS residues 3-389 – Trypanosoma brucei
    • 3hv0 – TRrpS residues 206-593 – Cryptosporidium parvum
    • 3foc – GlTrpRS – Giardia lamblia
    • 1o5t – hTrpRS catalytic fragment
    • 1ulh – hTrpRS residues 35-424
    • 2el7 – TtTrpRS
    • 2ip1, 3kt0 – yTrpRS – yeast
    • 2yy5 – TrpRS – Mycoplasma pneumoniae
    • 2g36 – TmTrpRS
    • 1bks – StTrpRS + pyridoxal phosphate
  • Trp-RS + small substrates or analogs
    • 3a05 – ApTrpRS + Trp
    • 3kt3 – yTrpRS + Trp-adenylate
    • 3kt6, 3kt8 – yTrpRS + Trp
    • 3jxe – PhTrpRS + Trp-adenylate
    • 3fhj, 3fio – BsTrpRS + Trp + AMP + Pi
    • 2quh – hTrpRS + Trp
    • 2qui - hTrpRS + Trp-amide + ATP
    • 2quj - hTrpRS + Trp-adenylate
    • 2quk – hTrpRS + ATP
    • 2ov4 – GsTrpRS + adenosine tetraphosphate
    • 1i6k, 1i6l, 1i6m – GsTrpRS + Trp-adenylate
    • 1yid, 2a4m – DrTrpRS + ATP
    • 1yi8, 1yia – DrTrpRS + Trp
    • 1mau – GsTrpRS + Trp + ATP
    • 1maw, 1m83 - GsTrpRS + ATP
    • 1mb2 - GsTrpRS + Trp
    • 3tze - TrpRS + Trp - Encephalitozoon cuniculi
    • 3tzl - CjTrpRS + Trp + ADP
    • 3sz3 - TrpRS + Trp - Vibrio cholerae
  • Trp-RS + tRNA
  • Tyr-RS
  • Tyr-RS + small substrates or analogs
    • 3ts1 – GsTyrRS + Tyr-adenylate intermediate
    • 4ts1 – GsTyrRS + Tyr
    • 3p0h, 3p0i, 3p0j – LmTyrRS + inhibitor
    • 3n2y – MjTyrRS + tetrazolyl phenylalanine
    • 2zp1 – MjTyrRS (mutant) + Tyr
    • 1zh0 - MjTyrRS (mutant) + naphthyl-Ala
    • 1zh6 - MjTyrRS (mutant) + acetyl-Phe
    • 2ag6 - MjTyrRS (mutant) + bromo-Phe
    • 4hjx - MjTyrRS (mutant) + di-fluoro-Tyr
    • 2yxn – EcTyrRS residues 1-322 + azido-Tyr
    • 1vbm – EcTyrRS + Tyr-SA
    • 1vbn – EcTyrRS (mutant) + Tyr-SA
    • 1wq3, 1wq4 - EcTyrRS (mutant) + Tyr
    • 1x8x – EcTyrRS + Tyr
    • 2pid – hTyrRS residues 28-375 + Tyr-SA
    • 2j5b – TyrRS residues 2-346 + Tyr-ol – Acanthamoeba polyphaga minivirus
    • 2dlc – yTyrRS + tRNA + Tyr-SA
    • 2cyb – AfTyrRS + Tyr - Archaeoglobus fulgidus
    • 2cyc – PhTyrRS + Tyr
    • 1q11 – hTyrRS residues 1-364 + Tyr-ol
    • 1h3e - TtTyrRS + Tyr-tRNA + Tyr-ol + ATP
    • 1h3f - TtTyrRS + Tyr-ol
    • 1jh3 – GsTyrRS C-terminal – NMR
    • 1jii, 1jij, 1jil, 1jik – SaTyrRS + inhibitor
  • Tyr-RS + tRNA
    • 1j1u – MjTyrRS + Tyr-tRNA
    • 2rkj – NcTyrRS + RNA
  • Val-RS
  • Val-RS ternary complex
    • 1ivs – TtValRS + Val-SA + Val-tRNA
    • 1gax - TtValRS + Val-adenylate analog + Val-tRNA
  • Class II aaRS
  • Ala-RS
  • Ala-RS + small substrates or analogs
    • 3hxu, 3hxv, 3hxw – EcAlaRS catalytic fragment + aa-adenylate
    • 3hxz, 3hy0, 3hy1 - EcAlaRS catalytic fragment (mutant) + aa-adenylate
    • 3hxx - EcAlaRS catalytic fragment + AMPPCP
    • 3hxy - EcAlaRS catalytic fragment + AMPPCP + Ala-AMP + PCP
    • 3htz - AaAlaRS residues 2-454 + Ser
    • 1yfr – AaAlaRS + ATP
    • 1yfs – AaAlaRS + Ala
    • 1yft, 1ygb - AaAlaRS catalytic fragment + aa
    • 2zzg - PhAlaRS + Ala-SA<br /
    • 2ztg – AfAlaRS + Ala-SA
  • Asp-RS
    • 3nen, 1b8a – TkAspRS - Thermococcus kodakarensis
    • 3i7f – EhAspRS
    • 1wyd – AspRS – Sulfolobus tokodaii
    • 1eov - yAspRS

1n9w, 1l0w, 1g51 – TtAspRS

  • Asp-RS + small substrates or analogs
    • 3nel – TkAspRS + Asp
    • 3nem - TkAspRS + Asp-adenylate
  • Asp-RS + tRNA
  • Asp-RS ternary complex
    • 1il2, 1c0a – EcAspRS + Asp-tRNA + Asp-adenylate
  • Asn-RS
    • 1x56 - PhAsnRS
    • 2kqr – BmAsnRS N-terminal – NMR – Brugia malayi
  • Asn-RS + small substrates or analogs
    • 2xti – BmAsnRS catalytic fragment + Asn-adenine analog
    • 2xgt - BmAsnRS catalytic fragment + Asn-SA
    • 1x54 – PhAsnRS + Asn-adenylate
    • 1x55 - PhAsnRS + Asn-SA
    • 11as – EcAsnRS + Asn
    • 12as - EcAsnRS + Asn + AMP
  • Gly-RS
    • 1ati – TtGlyRS
    • 2q5h – hGlyRS residues 55-739
    • 2q5i - hGlyRS residues 55-739 (mutant)
    • 2pme – hGlyRS
    • 2pmf – hGlyRS (mutant)
    • 1j5w – TmGlyRS α chain
  • Gly-RS + small substrates or analogs
    • 2zt5, 2zxf – hGlyRS residues 55-739 + bis-adenosine tetraphosphate
    • 2zt6 - hGlyRS residues 55-739 + AMPCPP
    • 2zt7 - hGlyRS residues 55-739 + Gly + ATP
    • 2zt8 - hGlyRS residues 55-739 + Gly-AMP analog
    • 1b76 – TtGlyRS + ATP
    • 1ggm – TtGlyRS + Gly-adenylate
  • His-RS
    • 3net – HisRS – Nostoc
    • 1h4v – TtHisRS
    • 1qe0 – SaHisRS
    • 3hri – TbHisRS
    • 1x59 – hHisRS WHEP-TRS domain - NMR
  • His-RS + small substrates or analogs
    • 3lc0 – HisRS residues 45-478 + His – Trypanosoma cruzi
    • 1adj – TtHisRS + His
    • 3hrk - TbHisRS + His-adenylate
    • 2el9 - EcHisRS + His-SA
    • 1kmm, 1ady - EcHisRS + His-adenylate
    • 1kmn - EcHisRS + His-ol + ATP
  • Phe-RS
    • 1pys – TtPheRS
    • 3l4g, 3cmq – hPheRS
    • 2cxi – PhPheRS β chain N-terminal
      3ica – PheRS β chain – Porphyromonas gingivalis
  • Phe-RS + small substrates or analogs
    • 3pco – EcPheRS + phenylalanine+ AMP
    • 3hfz, 2amc – TtPheRS α+β chains + Tyr
    • 2akw, 1b70 - TtPheRS α+β chains + Phe
    • 1jjc, 1b7y - TtPheRS α+β chains + Phe-adenylate
    • 2aly - TtPheRS α+β chains + Phe-SA
    • 2rhq, 2rhs – PheRS α+β chains (mutant) + inhibitor – Staphylococcus haemolyticus
  • Phe-RS + tRNA
    • 1eiy - TtPheRS α+β chains + Phe-tRNA
  • Phe-RS ternary complex
    • 2iy5 - TtPheRS α+β chains + Phe-ol + Phe-tRNA
  • Pro-RS
    • 1hc7 – TtProRS
    • 2i4l – RpProRS – Rhodopseudomonas palustris
    • 1nj2 - MtProRS – Methanothermobacter thermautotrophicus
    • 1nj8 – MjProRS
  • Pro-RS + small substrates or analogs
    • 3ial – GlProRS residues 34-542 + Pro-adenylate
    • 2i4m, 2i4n – RpProRS + aa-SA
    • 2i4o – RpProRS + ATP
    • 2j3l – EfProRS + Pro-SA – Enterococcus faecalis
    • 2j3m – EfProRS + Pro-ol + ATP
    • 1nj1, 1nj5, 1nj6 – MtProRS + aa-SA
    • 1h4t - TtProRS + Pro
  • Pro-RS ternary complex
    • 1h4q - TtProRS + Pro-tRNA + Pro-ol
    • 1h4s - TtProRS + Pro-tRNA + Pro-SA
  • Ser-RS
    • 3lsq – TbSerRS
    • 1sry - TtSerRS
    • 3err – TtSerRS/dynein heavy chain
    • 2zr3 – PhSerRS
    • 2dq3 – AaSerRS
    • 2du7 – MjSerRS
    • 2odr – SerRS – Methanococcus maripaludis
    • 2cim – MbSerRS – Methanosarcina barkeri
    • 1wle – SerRS – bovine
  • Ser-RS + small substrates or analogs
    • 2zr2 – PhSerRS + ATP
    • 2cj9 – MbSerRS + Ser-SA
    • 2cjb – MbSerRS + Ser
    • 2cja – MbSerRS + ATP
    • 1ses, 1set – TtSerRS + Ser-adenylate analog
    • 3lss – TbSerRS + ATP
  • Ser-RS + tRNA
    • 1ser – TtSerRS + Ser-tRNA
    • 2du4 - AfSerRS + Cys-tRNA
  • Ser-RS ternary complex
    • 2du3 – AfSerRS + Cys-tRNA + phosphoserine
    • 2du5, 2du6 - AfSerRS (mutant) + Cys-tRNA + phosphoserine
  • Thr-RS
    • 1y2q - PaThrRS editing domain
    • 1wwt – hThrRS TGS domain – NMR
    • 1tje - EcThrRS editing domain
  • Thr-RS + small substrates or analogs
    • 3pd2, 3pd3, 3pd4, 3pd5 – PaThrRS editing domain + aa-aminoadenosine
    • 2hkz – PaThrRS editing domain + Ser
    • 2hl0, 2hl1 - PaThrRS editing domain + Ser-adenylate
    • 2hl2 - PaThrRS editing domain + Ser-SA
    • 1tke - EcThrRS editing domain + Ser
    • 1tkg - EcThrRS editing domain + Ser-SA
    • 1tky - EcThrRS editing domain + Ser-adenylate
    • 1fyf, 1evl - EcThrRS catalytic and anticodon-binding domains + aa-SA
    • 1evk - EcThrRS catalytic and anticodon-binding domains + Thr
    • 1nyq – SaThrRS + Thr-SA
    • 1nyr – SaThrRS + ATP
  • Thr-RS + tRNA
    • 1qf6 – EcThrRS + Thr-tRNA
    • 1kog – EcThrRS catalytic and anticodon-binding domains + mRNA
  • Multifunctional RS

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Ann Taylor
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