Thioredoxin

File:1ert.png

Crystal Structure of Thioredoxin 1ert

Thioredoxin (Trx) is an enzyme which facilitates the reduction of proteins by cysteine thiol-disulfide exchange. They contain a CXXC motif. Trx-1 is a mammalian cellular protein. Trx-2 is mitochondria-specific. In higher plants, Trx are divided to 6 groups based on their sequence. Trx M, X and Y are found in prokaryotes while F, H and O are found in eukaryotes. The images at the left and at the right correspond to one representative Trx, i.e. the crystal structure of human Thioredoxin (1ert).

3D Structures of Thioredoxin3D Structures of Thioredoxin

Updated on 12-August-2013

TrxTrx

3e3e, 2hsh, 1aiu, 1erv, 1erw, 3m9j, 3m9k – hTrx (mutant) – human
3kd0 - hTrx (mutant)+CdCl2
1cqg, 1cqh - hTrx (mutant)+Ref-1 peptide – NMR
1mdi, 1mdj, 1mdk - hTrx + Target peptide of NFKB – NMR
2hxk, 2ifq, 2iiy – hTrx S-nitroso
1auc, 1ert, 1eru, 1trs, 1tru, 1trv, 1trw, 3trx, 4trx - hTrx
3hxs – BfTrx fragment – Bacteroides fragilis
3hyp - BfrxI fragment (mutant)
3hz4 – Trx – Methanosarcina mazei
2k9f - Trx fragment+DsbD N-terminal – Neisseria meningitides – NMR
3die – SaTrx (mutant) – Staphylococcus aureus
2voc - BsTrx (mutant) – Bacillus subtilis
2gzy, 2gzz – BsTrx – NMR
2ipa – BsTrx (mutant)+ArcS (mutant) - NMR
2h6x, 2trx, 1srx – EcTrx
1xoa, 1xob – EcTrx - NMR
1m7t – hTrx/EcTrx chimera - NMR
3dxb – hTrx+Puf60 C-terminal
3emx – Trx – Aeropyrum pernix
2vim – Trx – Fasciola hepatica
2yzu, 2cvk, 1v98 – TtTrx – Thermus thermophilus
2lst – TtTrx - NMR
2e0q – Trx (mutant) – Sulfolobus tokodaii
2o7k – SaTrx
2o85, 2o87, 2o89 – SaTrx (mutant)
2i4a – Trx – Acetobacter aceti
2j23 – Trx – Malassezia sympodialis
2f51 – Trx – Trichomonas vaginalis
1t00 – Trx – Streptomyces coelicolor
1xw9, 1xwa, 1xwb, 1xwc – Trx – Drosophila melanogaster
1rqm, 1nsw, 1nw2 – Trx (mutant) – Alicyclobacillus acidocaldarius – NMR
1syr – PfTrx – Plasmodium falciparum
1r26 – Trx – Trypanosoma brucei brucei
1gl8 – Trx – spinach- NMR
1fo5 – Trx – Methanocaldococcus janaschii – NMR
1quw – Trx – Bacillus acidocaldarius – NMR
2l5l – Trx – Bacteroides vulgatus – NMR
2tir, 4hua, 4hu9, [[4hu7] - EcTrx (mutant) – Escherichia coli
2xbi – SmTrx – Schistosoma mansoni
2xbq, 2xc2 – SmTrx (mutant)
3zzx, 4aj8, 4aj7, 4aj6 – Trx – Litopenaeus vannamei 4fyu – Trx – Wuchereria bancrofti
4knd – Trx – Anaeromyxobacter dehalogenans
3vfi – Trx – Silicabacter phage dss3ϕ2

Trx-1Trx-1

3f3q, 2i9h – yTrx-1 – yeast
3f3r – yTrx-1 (mutant)
3dyr, 2h6y, 2h6z, 2h70, 2h71, 2h72, 2h73, 2h74, 2h75, 2h76, 2fch, 2fd3, 1keb, 2eio, 2eiq, 2eir, 1zcp, 1zzy, 1txx, 1tho – EcTrx-1 (mutant)
1f6m – EcTrx-1+Trx reductase+AADP+
2ajq – EpTrx-1 (mutant)+DNA primer+DNA template+DNA polymerase – Enterobacteria phage T7
1zyq – EpTrx-1 (mutant)+DNA primer+DNA template+DNA polymerase+ATP
1x9m, 1x9s, 1x9w – EpTrx-1+DNA primer+DNA template+DNA polymerase+N-2-acetylaminofluorene-adducted DNA
1t8e – EpTrx-1 +DNA primer+DNA template+DNA polymerase+dCTP
1tk0 – EpTrx-1+DNA primer+DNA template+DNA polymerase+ddCTP+8-oxo-guanosine
1tk5 - EpTrx-1+DNA primer+DNA template+DNA polymerase+8-oxo-guanosine
1tk8 - EpTrx-1+DNA primer+DNA template+DNA polymerase+dAMP+8-oxo-guanosine
1tkd - EpTrx-1+DNA primer+DNA template+DNA polymerase+dCMP+8-oxo-guanosine
1skr - EpTrx-1+DNA primer+DNA template+DNA polymerase+ddATP
1sks, 1skw, 1sl0, 1sl1, 1sl2 - EpTrx-1+DNA primer+DNA template+DNA polymerase+thymine
1t7p - EpTrx-1+DNA primer+DNA template+DNA polymerase+ddAMP+ddGTP
2bto – Trx-1+tubulin btuba – Prosthecobacter dejongeii
1oaz – Trx-1+immunoglobulin E – rat
3tco - SsTrx-1 fragment – Sulfolobus solfataricus
4j57, 4j56 – PfTrx-1 + Trx reductase (mutant)

Trx-2Trx-2

1w4v, 1w89, 1uvz – hTrx-2
3hhv – SsTrx-2 fragment
2fa4 – yTrx-2
2hsy – yTrx-2 - NMR
3pin - yTrx-2+peptide methionine sulfoxide reductase
2ppt – Trx-2 – Rhodobacter capsulatus
1thx – Trx-2 – Anabaena
3ul3 – PfTrx-2

Trx-3Trx-3

2oe0, 2oe1, 2oe3 – yTrx-3

Trx CTrx C

2i1u – MtTrx C – Mycobacterium tuberculosis
2l4q, 2l59 – MtTrx C - NMR
3nof – MtTrx (mutant)
3o6t – MtTrx (mutant)+quinol

Trx FTrx F

2pu9 – SsTrx F+ferredoxin thioredoxin reductase – Synechocystis
2pvo - SsTrx F+ferredoxin thioredoxin reductase+ferredoxin 1
1f9m – sTrx F – spinach
1faa - sTrx F (mutant)

Trx HTrx H

3d21 – pTrx H – poplar
3d22 - pTrx H (mutant)
1ti3 - pTrx H - NMR
2vlt, 2vlu, 2vlv, 2vm1, 2vm2 - bTrx H – barley
2iwt - bTrx H+α-amylase subtilisin inhibitor
1wmj – Trx H – Oryza sativa – NMR
1xfl – Trx H – Arabidopsis thaliana - NMR
1ep7 – CrTrx H – Chlamydomonas reinhardtii
1ep8 - CrTrx H (mutant)
1tof - CrTrx H - NMR

Trx MTrx M

2puk - SsTrx M+ferredoxin thioredoxin reductase
1fb0, 1fb6 - sTrx M
1dby – CrTrx M – NMR