Proliferating Cell Nuclear Antigen: Difference between revisions
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[[Image:1rwz.png|left|200px|thumb|Crystal Structure of Proliferating Cell Nuclear Antigen [[1rwz]]]] | [[Image:1rwz.png|left|200px|thumb|Crystal Structure of Proliferating Cell Nuclear Antigen [[1rwz]]]] | ||
{{STRUCTURE_1rwz| PDB=1rwz | SIZE= | {{STRUCTURE_1rwz| PDB=1rwz | SIZE=400| SCENE=Proliferating_Cell_Nuclear_Antigen/Cv/1 |right|CAPTION=Proliferating Cell Nuclear Antigen [[1rwz]] }} | ||
[[Proliferating Cell Nuclear Antigen]] (PCNA) acts as a DNA sliding clamp by encircling the DNA and linking it to the genome. It is a processivity factor for DNA polymerase (Dpo) δ in eukaryotic cells. The images at the left and at the right correspond to one representative PCNA, ''i.e.'' the crystal structure of Proliferating Cell Nuclear Antigen from ''Archaeglobus fulgidus'' ([[1rwz]]). | [[Proliferating Cell Nuclear Antigen]] (PCNA) acts as a DNA sliding clamp by encircling the DNA and linking it to the genome. It is a processivity factor for DNA polymerase (Dpo) δ in eukaryotic cells. The images at the left and at the right correspond to one representative PCNA, ''i.e.'' the crystal structure of Proliferating Cell Nuclear Antigen from ''Archaeglobus fulgidus'' ([[1rwz]]). | ||
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== 3D Structures of Proliferating Cell Nuclear Antigen == | == 3D Structures of Proliferating Cell Nuclear Antigen == | ||
''Update | ''Update December 2011'' | ||
===Unliganded PCNA=== | ===Unliganded PCNA=== | ||
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[[1vym]], [[1w60]] – hPCNA - human<br /> | [[1vym]], [[1w60]] – hPCNA - human<br /> | ||
[[2io4]] – SsPCNA B (mutant) + PCNA C - ''Sulfolobus solfataricus''<br /> | [[2io4]] – SsPCNA B (mutant) + PCNA C - ''Sulfolobus solfataricus''<br /> | ||
[[2hii]], [[2hik]], [[2ixi]] - SsPCNA A + PCNA B + PCNA C<br /> | [[2hii]], [[2hik]], [[2ixi]], [[2ix2]] - SsPCNA A + PCNA B + PCNA C<br /> | ||
[[2nti]] - SsPCNA A + PCNA B (mutant) + PCNA C<br /> | [[2nti]] - SsPCNA A + PCNA B (mutant) + PCNA C<br /> | ||
[[2ijx]] - SsPCNA A<br /> | [[2ijx]] - SsPCNA A<br /> | ||
[[1iz4]], [[1iz5]] – PfPCNA (mutant) - ''Pyrococcus furiosus''<br /> | [[1iz4]], [[1iz5]], [[1ge8]] – PfPCNA (mutant) - ''Pyrococcus furiosus''<br /> | ||
[[3hi8]], [[3ifv]] - PCNA - ''Haloferax volcanii''<br /> | [[3hi8]], [[3ifv]] - PCNA - ''Haloferax volcanii''<br /> | ||
[[3aix]], [[3aiz]] - | [[3aix]], [[3aiz]] - StPCNA B + PCNA C – ''Sulfolobus tokodaii''<br /> | ||
[[1ud9]] - StPCNA<br /> | |||
[[3p91]] – PCNA – ''Entamoeba histoytiica'' | [[3p91]] – PCNA – ''Entamoeba histoytiica'' | ||
Revision as of 12:57, 14 December 2011
Proliferating Cell Nuclear Antigen (PCNA) acts as a DNA sliding clamp by encircling the DNA and linking it to the genome. It is a processivity factor for DNA polymerase (Dpo) δ in eukaryotic cells. The images at the left and at the right correspond to one representative PCNA, i.e. the crystal structure of Proliferating Cell Nuclear Antigen from Archaeglobus fulgidus (1rwz).
3D Structures of Proliferating Cell Nuclear Antigen3D Structures of Proliferating Cell Nuclear Antigen
Update December 2011
Unliganded PCNAUnliganded PCNA
1rwz – AfPCNA - Archaeglobus fulgidus
3lx1 - TkPCNA1 - Thermococcus kodakarensis
3lx2 - TkPCNA2
3lox, 1plq, 1plr – yPCNA - yeast
3f1x, 3gpm, 3gpn, 3f1w - yPCNA (mutant)
3l0x - yPCNA N fragment + C fragment
3gpe - yPCNA N fragment + SUMO-C fragment
1vym, 1w60 – hPCNA - human
2io4 – SsPCNA B (mutant) + PCNA C - Sulfolobus solfataricus
2hii, 2hik, 2ixi, 2ix2 - SsPCNA A + PCNA B + PCNA C
2nti - SsPCNA A + PCNA B (mutant) + PCNA C
2ijx - SsPCNA A
1iz4, 1iz5, 1ge8 – PfPCNA (mutant) - Pyrococcus furiosus
3hi8, 3ifv - PCNA - Haloferax volcanii
3aix, 3aiz - StPCNA B + PCNA C – Sulfolobus tokodaii
1ud9 - StPCNA
3p91 – PCNA – Entamoeba histoytiica
PCNA + DpoPCNA + Dpo
2zvk – hPCNA + hDpo ε
2zvl – hPCNA + hDpo κ
2zvm – hPCNA + hDpo τ
3fds – SsPCNA B + PCNA C + SsDpo IV
3a2f - PfPCNA + Dpo
PCNA complexesPCNA complexes
1vyj, 1u76, 1u7b – hPCNA + peptide
1axc - hPCNA + P21/WAF1 C-terminat
1ul1 - hPCNA + Flap exonuclease-1
3p87 - hPCNA + RNase H2 subunit B (mutant)
3p83 - AfPCNA + RNase H2
1rxm – AfPCNA + Flap exonuclease-1 peptide
1rxz - AfPCNA + Flap structure-specific endonuclease
3l0w, 3l10 - yPCNA + monoubiquinated PCNA
1sxj – yPCNA + replication factor C
2od8 - yPCNA + DNA ligase fragment
3k4x - yPCNA + DNA
2izo - SsPCNA B + PCNA C + Flap structure-specific endonuclease
1isq - PfPCNA (mutant) + replication factor C large subunit
2zvw - PCNA + cyclin-dependent kinase inhibitor 1 - Arabidopsis thaliana